沙加霉素
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- CAS号:
- 66803-19-8
- 英文名:
- MICRONOMICIN SULFATE
- 英文别名:
- Sagamicin sulfate;MICRONOMYCIN SULFATE;MICRONOMICIN SULFATE;Gentamicin C2b sulfate;sulfate,d-1-6))-2-deoxy;Micronomicin Sulfate (~80%);Micronomicin sulfate JAS1998;MICRONOMICIN SULFATE USP/EP/BP;Micronomicin Sulfate CAS: 66803-19-8;6'-N-METHYLGENTAMICIN C1A HEMIPENTASULFATE
- 中文名:
- 沙加霉素
- 中文别名:
- 小诺米星;相模霉素;沙加霉素;硫酸小诺米星;硫酸小诺霉素;硫酸相模霉素;硫酸沙加霉素;小诺霉素(标准品);硫酸小诺霉素(~80%);硫酸小诺米星/硫酸沙加霉素
- CBNumber:
- CB5390867
- 分子式:
- C20H43N5O11S
- 分子量:
- 561.65
- MOL File:
- 66803-19-8.mol
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沙加霉素化学性质
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熔点:
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>205°C (dec.)
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沸点:
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667℃
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RTECS号:
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WK2196000
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闪点:
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>110°(230°F)
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储存条件:
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Hygroscopic, Refrigerator, under inert atmosphere
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溶解度:
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DMSO (Very Slightly, Heated, Sonicated), Water (Slightly)
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形态:
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Solid
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颜色:
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White to Pale Yellow
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水溶解性:
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Freely soluble in water
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稳定性:
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Hygroscopic
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沙加霉素性质、用途与生产工艺
Micronomicin sulfate (Gentamicin C2b sulfate) 是从 Micromonospora 中分离出来的氨基糖苷抗生素 (antibiotic)。Micronomicin sulfate 是一种接近庆大霉素类抗生素的广谱抗生素，对假单胞菌、变形杆菌、肺炎克雷伯菌、沙雷菌等具有高的抑制活性 (MIC=0.001-8.3 μg/ml)。
MIC: 0.001-8.3 μg/ml (
Pseudomonas
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Proteus
,
Klebsiella pneumoniae
,
Serratia
)
Micronomicin has a potent antibacterial activity, it is active against
Staphylococcus aureus
FDA 209 P,
Staphylococcus aureus
with the minimal inhibitory values of 0.01 μg/ml. It is also against
Escherichia coli
St.M. 589, Baker 2, F 14-BK, and R5/W677 with the minimal inhibitory values of 0.75 μg/ml, 0.3 μg/ml, 0.03 μg/ml and 0.03 μg/ml. And it is active against
Pseudomonas aeruginosa
strains and
lebsiella pneumoniae
strains (MICs = 0.03-17.5 μg/ml).
Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD
50
in mice of 93 mg/kg.Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over.
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Animal Model:
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Wistar rats
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Dosage:
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4, 10, 25, 63 mg/kg and 100 mg/kg
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Administration:
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Intravenous injection; 30 days
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Result:
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Led to death of rat at 100 mg/kg.
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用途
属抗生素类药
用途
用于革兰阴性杆菌所致的各种感染，如菌血症、呼吸系统、胆管、尿路感染等。局部滴眼治疗敏感菌引起的眼睑炎、泪囊炎、结膜炎、角膜炎等。
沙加霉素
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-108307 | 沙加霉素
Micronomicin sulfate | 66803-19-8 | 50mg | 520元 |
| 2024/01/25 | HY-108307 | 沙加霉素
Micronomicin sulfate | 66803-19-8 | 100mg | 680元 |
沙加霉素
生产厂家
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沙加霉素国内生产厂家
66803-19-8, 沙加霉素 相关搜索:
- 日用化学品
- 抗生素类
- 医药、农药及染料中间体
- 医药原料药
- 抗生素
- C20H41N5O7H2O4S
- C20H43N5O11S
- C20H41N5O7H2SO4
- GENTAMICIN C2B SULFATE; ANTIBIOTIC XK-62-2 SULFATE; SAGAMICIN SULFATE
- 硫酸小诺霉素(~80%)
- 硫酸小诺霉素,沙加霉素,硫酸小诺米星
- 相模霉素
- 沙加霉素
- 硫酸小诺米星
- 硫酸小诺霉素
- 硫酸小诺米星/硫酸沙加霉素
- 硫酸相模霉素
- 硫酸沙加霉素
- 小诺霉素(标准品)
- 硫酸小诺霉素/硫酸小诺米星/硫酸沙加霉素
- 小诺米星
- 66803-19-8
- Gentamicin C2b sulfate
- Sagamicin sulfate
- MICRONOMICIN SULFATE USP/EP/BP
- Micronomicin Sulfate (~80%)
- (2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(methylaminomethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol,sulfuric acid
- Micronomicin Sulfate CAS: 66803-19-8
- yranosyl-(1-4)-o-(3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl-(
- sulfate,d-1-6))-2-deoxy
- streptamine,o-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-d-erythro-hexop
- D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-a-D-erythro-hexopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-2-deoxy-, sulfate (salt) (9CI)
- Micronomicin sulfate JAS1998
- MICRONOMYCIN SULFATE
- MICRONOMICIN SULFATE
- 6'-N-METHYLGENTAMICIN C1A HEMIPENTASULFATE