硫替丁
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- CAS号:
- 69014-14-8
- 英文名:
- TIOTIDINE
- 英文别名:
- TIOTIDINE;ICI-125211;1-cyano-3-[2-[(2-guanidinothiazol-4-yl)methylthio]ethyl]-2-methyl-guanidine;1-Methyl-2-cyano-3-[2-[2-(diaminomethyleneamino)thiazole-4-ylmethylthio]ethyl]guanidine;1-Methyl-2-cyano-3-[2-[[2-(diaminomethyleneamino)thiazole-4-yl]methylthio]ethyl]guanidine;N-[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazoyl]methyl]thio]ethyl]-N'-cyano-N''-methylguanidine;N'-Cyano-N-[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]-N''-methylguanidine;N-[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]-N'-cyano-N''-methylguanidine;1-cyano-3-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-2-methylguanidine;1-[2-[[2-[bis(azanyl)methylideneamino]-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-3-cyano-2-methyl-guanidine
- 中文名:
- 硫替丁
- 中文别名:
- 硫替丁;化合物 T13163
- CBNumber:
- CB6278113
- 分子式:
- C10H16N8S2
- 分子量:
- 312.42
- MOL File:
- 69014-14-8.mol
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硫替丁化学性质
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沸点:
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490.1±55.0 °C(Predicted)
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密度:
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1.50±0.1 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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Soluble to 10 mM in ethanol and to 100 mM in DMSO
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形态:
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Powder
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酸度系数(pKa):
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pKa 6.80 (Uncertain)
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硫替丁性质、用途与生产工艺
Tiotidine (ICI 125211) 是一种有效选择性 H2 受体 (histamine H2-receptor) 拮抗剂 (pA2=7.3-7.8)。Tiotidine (ICI 125211) 对 H1 和 H3 受体均具有低亲和力。
H
2
Receptor
7.3-7.8 (pA2)
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H
3
Receptor
4.8 (pA2)
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Tiotidine competitively antagonizes the positive chronotropic action of histamine with an apparent dissociation constant of 30 μM (23-38 μM). Tiotidine abolishes H2-mediated increases in contractile force leaving H2-mediated negative inotropic responses unopposed. The actions of histamine at the A-V node, manifested by lengthening of the P-R interval and A-V block, are attenuated by 2.5 x 10(-7) M Tiotidine.
Tiotidine actually behaves as an inverse agonist in U-937 cells, diminishing basal cAMP levels.
硫替丁
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-101232 | 硫替丁 Tiotidine | 69014-14-8 | 1mg | 545元 |
2024/04/30 | HY-101232 | 硫替丁 Tiotidine | 69014-14-8 | 5mg | 1200元 |
硫替丁
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69014-14-8, 硫替丁 相关搜索:
- Histamine receptor
- C10H16N8S2
- 化合物 T13163
- 硫替丁
- 69014-14-8
- 1-cyano-3-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-2-methylguanidine
- 1-cyano-3-[2-[(2-guanidinothiazol-4-yl)methylthio]ethyl]-2-methyl-guanidine
- 1-[2-[[2-[bis(azanyl)methylideneamino]-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-3-cyano-2-methyl-guanidine
- N'-Cyano-N-[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]-N''-methylguanidine
- N-[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]-N'-cyano-N''-methylguanidine
- ICI-125211
- 1-Methyl-2-cyano-3-[2-[2-(diaminomethyleneamino)thiazole-4-ylmethylthio]ethyl]guanidine
- 1-Methyl-2-cyano-3-[2-[[2-(diaminomethyleneamino)thiazole-4-yl]methylthio]ethyl]guanidine
- N-[2-[[[2-[(Aminoiminomethyl)amino]-4-thiazoyl]methyl]thio]ethyl]-N'-cyano-N''-methylguanidine
- TIOTIDINE