法南色林
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- CAS号:
- 127625-29-0
- 英文名:
- Fananserin
- 英文别名:
- RP-62203;Fananserin;2-[3-[4-(4-Fluorophenyl)piperazino]propyl]-2H-naphth[1,8-cd]isothiazole 1,1-dioxide;2-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide;2-[3-[4-(4-Fluorophenyl)-1-piperazinyl]propyl]-2H-naphthyl[1,8-cd]isothiazole-1,1-dioxide;2H-Naphth[1,8-cd]isothiazole, 2-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-, 1,1-dioxide;Fananserin,Inhibitor,5-HT Receptor,inhibit,5-HT2,RP62203,RP-62203,dopamine,Dopamine Receptor,Serotonin Receptor,5-hydroxytryptamine Receptor
- 中文名:
- 法南色林
- 中文别名:
- 法南色林;化合物 T15270;2-(3-(4-(4-氟苯基)哌嗪-1-基)丙基)-2H-萘并[1,8-CD]异噻唑 1,1-二氧化物
- CBNumber:
- CB71073778
- 分子式:
- C23H24FN3O2S
- 分子量:
- 425.52
- MOL File:
- 127625-29-0.mol
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法南色林化学性质
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熔点:
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95-97 °C(Solv: acetonitrile (75-05-8))
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沸点:
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641.1±65.0 °C(Predicted)
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密度:
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1.331±0.06 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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Soluble to 100 mM in DMSO
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形态:
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Powder
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酸度系数(pKa):
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7.31±0.10(Predicted)
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法南色林性质、用途与生产工艺
Fananserin (RP 62203) 是一种口服生物可利用，高效、选择性的 5- 羟色胺 (5-HT2) 受体拮抗剂，对大鼠 5-HT2 受体作用的 Ki 值为 0.37 nM。Fananserin也是一种选择性的多巴胺 D4 受体 拮抗剂，对人多巴胺 D4 受体作用的 Ki 值为 2.93 nM。
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5-HT
2
Receptor
0.37 nM (Ki)
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D
4
Receptor
2.93 nM (Ki)
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Fananserin is relatively selective for 5-HT
2
receptor, having lower affinity for the 5-HT
1A
receptor and very low affinity for the 5-HT
3
receptor.
Fananserin displaces [
3
H]spiperone binding to recombinant human dopamine D 4 receptors with a K
i
of 2.93 nM.
RP 62203 displays low to moderate affinity for α1-adrenoceptors, dopamine D2 receptors and histamine H
1
receptors.
Fananserin displaces
[125I]
AMIK from 5-HT
2
receptors with an IC
50
of 0.21 nM in rat frontal cortex.
Fananserin shows moderate affinity for alpha 1-adrenoceptors in the rat thalamus (IC
50
= 14 nM) and for histamine H1 receptors in the guinea-pig cerebellum (IC
50
= 13 nM).
Fananserin (0.5-4 mg/kg; p.o.) increases the duration of deep nonrapid eye movement (NREM) sleep at the expense of wakefulness in a dose-dependent manner.
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Animal Model:
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Adult male Sprague Dawley rats (250-300 g)
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Dosage:
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0.5 mg/kg, 1 mg/kg,2 mg/kg, 4 mg/kg
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Administration:
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Oral administration
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Result:
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Increased the duration of deep nonrapid eye movement (NREM) sleep at the expense of wakefulness in a dose-dependent manner from 0.5 mg/kg.
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法南色林
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-103104 | Fananserin | | 1 mg | 716元 |
| 2024/04/30 | HY-103104 | 法南色林
Fananserin | 127625-29-0 | 10mM * 1mLin DMSO | 2068元 |
法南色林
生产厂家
全球有 44家供应商
法南色林国内生产厂家
127625-29-0, 法南色林 相关搜索:
- 合成有机化合物配体
- 2-(3-(4-(4-氟苯基)哌嗪-1-基)丙基)-2H-萘并[1,8-CD]异噻唑 1,1-二氧化物
- 化合物 T15270
- 法南色林
- 127625-29-0
- Fananserin,Inhibitor,5-HT Receptor,inhibit,5-HT2,RP62203,RP-62203,dopamine,Dopamine Receptor,Serotonin Receptor,5-hydroxytryptamine Receptor
- 2-(3-(4-(4-fluorophenyl)piperazin-1-yl)propyl)-2H-naphtho[1,8-cd]isothiazole 1,1-dioxide
- 2H-Naphth[1,8-cd]isothiazole, 2-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-, 1,1-dioxide
- Fananserin
- 2-[3-[4-(4-Fluorophenyl)-1-piperazinyl]propyl]-2H-naphthyl[1,8-cd]isothiazole-1,1-dioxide
- RP-62203
- 2-[3-[4-(4-Fluorophenyl)piperazino]propyl]-2H-naphth[1,8-cd]isothiazole 1,1-dioxide