N-丙戊酰基甘氨酰胺
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- CAS号:
- 92262-58-3
- 英文名:
- VALROCEMIDE
- 英文别名:
- TV 1901;VALROCEMIDE;Valrocemide, >98%;Valrocemide(TV1901);N-Valproylglycinamide;Valrocemide (TV1901,VGD));N-(2-Amino-2-oxoethyl)-2-propylpentanamide;Pentanamide, N-(2-amino-2-oxoethyl)-2-propyl-;Valrocemide,Inhibitor,TV-1901,inhibit,TV 1901
- 中文名:
- N-丙戊酰基甘氨酰胺
- 中文别名:
- 丙戊塞胺;N-丙戊酰基甘氨酰胺;N-(2-氨基-2-氧代乙基)-2-丙基戊酰胺
- CBNumber:
- CB7511549
- 分子式:
- C10H20N2O2
- 分子量:
- 200.28
- MOL File:
- 92262-58-3.mol
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N-丙戊酰基甘氨酰胺化学性质
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沸点:
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417.5±28.0 °C(Predicted)
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密度:
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0.997
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 30mg/mL; DMSO: 30mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 25mg/mL
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形态:
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A solid
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酸度系数(pKa):
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15.23±0.46(Predicted)
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N-丙戊酰基甘氨酰胺性质、用途与生产工艺
Valrocemide（TV1901）是一种有前景的抗癫痫候选药物，具有广泛的抗惊厥活性。
In mice, valrocemide affords complete protection against maximal electroshock-, pentylenetetrazole-, picrotoxin-, and bicuculline-induced seizures and 6-Hz “psychomotor” seizures with median effective dose (ED
50
) values of 151, 132, 275, 248, and 237 mg/kg, respectively. Valrocemide is also effective in preventing sound-induced seizures in Frings audiogenic-seizure susceptible mice (ED
50
, 52 mg/kg). The median neurotoxic dose in mice is 332 mg/kg. After oral administration to rats, valrocemide is active in the MES test, with an ED
50
of 73 mg/kg, and the median neurotoxic dose is 1,000 mg/kg. Intraperitoneal administration of 300 mg/kg of valrocemide to hippocampal kindled Sprague–Dawley rats block generalized seizures and shorten the afterdischarge duration significantly. Valrocemide also provides complete protection from focal seizures in the corneally kindled rats (ED
50
, 161 mg/kg).
N-丙戊酰基甘氨酰胺
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-100379 | N-丙戊酰基甘氨酰胺
Valrocemide | 92262-58-3 | 10mM * 1mLin DMSO | 935元 |
| 2024/04/30 | HY-100379 | N-丙戊酰基甘氨酰胺
Valrocemide | 92262-58-3 | 10mg | 1250元 |
92262-58-3, N-丙戊酰基甘氨酰胺 相关搜索:
- 药靶配体
- N-(2-氨基-2-氧代乙基)-2-丙基戊酰胺
- 丙戊塞胺
- N-丙戊酰基甘氨酰胺
- 92262-58-3
- Pentanamide, N-(2-amino-2-oxoethyl)-2-propyl-
- Valrocemide,Inhibitor,TV-1901,inhibit,TV 1901
- Valrocemide(TV1901)
- Valrocemide, >98%
- Valrocemide (TV1901,VGD))
- N-Valproylglycinamide
- N-(2-Amino-2-oxoethyl)-2-propylpentanamide
- TV 1901
- VALROCEMIDE