艾替伏辛
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- CAS号:
- 21715-46-8
- 英文名:
- Etifoxine
- 英文别名:
- 36-801;Etifoxin;Etifoxine;HOE-36801;HOE-36-801;etafenoxine;Etifoxine (HOE36801);6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine;2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine;6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine
- 中文名:
- 艾替伏辛
- 中文别名:
- 艾替伏辛;2-乙基氨基-6-氯-4-甲基-4-苯基-4H-3;2-乙基氨基-6-氯-4-甲基-4-苯基-4H-3,1-苯并恶嗪
- CBNumber:
- CB7875113
- 分子式:
- C17H17ClN2O
- 分子量:
- 300.78
- MOL File:
- 21715-46-8.mol
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艾替伏辛化学性质
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熔点:
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90-92℃
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沸点:
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421.2±55.0 °C(Predicted)
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密度:
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1.1716 (rough estimate)
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蒸气压:
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0-1Pa at 20-25℃
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折射率:
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1.5800 (estimate)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:60.0(Max Conc. mg/mL);199.47(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);99.74(Max Conc. mM)
DMF:PBS (pH 7.2) (1:8):0.1(Max Conc. mg/mL);0.33(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);66.49(Max Conc. mM)-
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形态:
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Solid:particulate/powder
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酸度系数(pKa):
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4.89±0.40(Predicted)
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LogP:
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4.09-4.52 at 21-25℃ and pH7
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艾替伏辛性质、用途与生产工艺
Etifoxine 是一个非苯二氮卓类的、具有 GABA 能的化合物，是 GABAA 受体亚基 α1β2γ2 和 α1β3γ2 的阳性变构调节剂。Etifoxine 在啮齿类动物中显示出抗焦虑和抗惊厥活性。
Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX.
Etifoxine competitively inhibits [
35
S]TBPS binding with micromolar potency in rat brain.
Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice.
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Animal Model:
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Six-week old BALB/cByJ and C57BL/6J mice (20-25 g).
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Dosage:
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3.125-50 mg/kg.
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Administration:
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Intraperitoneal injection.
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Result:
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Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice.
BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lower
plasma levels of the compound at 15 and 30 min.
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类别
有毒物质
毒性分级
中毒
急性毒性
口服- 大鼠 LD50: 1500 毫克/ 公斤; 口服- 小鼠 LD50: 1388 毫克/ 公斤
可燃性危险特性
可燃; 火场分解有毒氯化物，氮氧化物气体
储运特性
库房低温, 通风, 干燥
灭火剂
水, 二氧化碳, 干粉, 砂土
艾替伏辛
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-16579A | 艾替伏辛
Etifoxine | 21715-46-8 | 5mg | 780元 |
| 2024/04/30 | HY-16579A | 艾替伏辛
Etifoxine | 21715-46-8 | 10mM * 1mLin DMSO | 858元 |
艾替伏辛
生产厂家
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艾替伏辛国内生产厂家
21715-46-8, 艾替伏辛 相关搜索:
- 膜转运/离子通道
- 膜转运
- 离子通道
- 神经系统用药
- 2-乙基氨基-6-氯-4-甲基-4-苯基-4H-3
- 2-乙基氨基-6-氯-4-甲基-4-苯基-4H-3,1-苯并恶嗪
- 艾替伏辛
- 21715-46-8
- 6-chloro-N-ethyl-4-methyl-4-phenyl-3,1-benzoxazin-2-amine
- Etifoxine (HOE36801)
- 4H-3,1-Benzoxazin-2-amine, 6-chloro-N-ethyl-4-methyl-4-phenyl-
- Etifoxine
- 2-Ethylamino-6-chloro-4-methyl-4-phenyl-4H-3,1-benzoxazine
- HOE-36-801
- HOE-36801
- Etifoxin
- 6-Chloro-2-ethylamino-4-methyl-4-phenyl-4H-3,1-benzoxazine
- 36-801
- etafenoxine