氯吡硫磷一氧
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- CAS号:
- 5598-15-2
- 英文名:
- CHLORPYRIFOS-OXON
- 英文别名:
- Dursbanoxon;CHLORPYRIFOXON;CHLORPYRIPHOXON;Fospirate-ethyl;Phospyrat ethyl;Dursban O-analog;CHLORPYRIFOS-OXON;chloropyrifosoxon;Chloropyrifos oxon;dursbanoxygenanalog
- 中文名:
- 氯吡硫磷一氧
- 中文别名:
- 氯吡硫磷一氧;毒死碑代谢物;毒死蜱氧化物;毒死蜱杂质标样A;毒死蜱氧化物 标准品;毒死蜱氧化物(5598-15-2) 标准品
- CBNumber:
- CB8195946
- 分子式:
- C9H11Cl3NO4P
- 分子量:
- 334.52
- MOL File:
- 5598-15-2.mol
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氯吡硫磷一氧化学性质
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沸点:
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357.8±42.0 °C(Predicted)
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密度:
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1.461±0.06 g/cm3(Predicted)
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储存条件:
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0-6°C
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溶解度:
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Chloroform (Slightly), Methanol (Slightly)
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形态:
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Low-Melting Solid
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酸度系数(pKa):
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-5.28±0.10(Predicted)
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颜色:
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Off-White to Pale Beige
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水溶解性:
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0.52g/L(24 ºC)
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稳定性:
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Hygroscopic, Moisture sensitive
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EPA化学物质信息:
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Chlorpyrifos O.A. (5598-15-2)
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氯吡硫磷一氧性质、用途与生产工艺
Chlorpyrifos-oxo 是一种 Chlorpyrifos 的活性代谢产物，是一种有效地抑制 AChE 的有效磷酸化剂。Chlorpyrifos-oxo 可以诱导微管蛋白亚基之间的交联并破坏微管功能。
Treatment of tubulin with 1.5 mM Chlorpyrifos-oxon (CPO) leads to protein aggregation. However, even at 1.5 μM Chlorpyrifos-oxon cross-linked trimers are apparent. Chlorpyrifos-oxon promotes isopeptide bond cross-linking of tubulin monomers to make multimers.
In PC12 cells in culture, 24 hours of exposure to Chlorpyrifos at a concentration 10-fold below the concentration that inhibits AChE activity (3.0 μM) impaired neurite outgrowth while Chlorpyrifos-oxon inhibits neurite outgrowth at 1.0 nM.
Chlorpyrifos-oxon (CPO) is rapidly detoxified by human liver microsomes via CYP-dependent deethylation and dearylation, and by glutathione-S-transferase. In addition, reactions with A-esterases such as paraoxonase 1 (PON 1) or B-esterases such as carboxylesterase and butyrylcholinesterase (BChE) in the liver may rapidly degrade or scavenge Chlorpyrifos-oxon.
Chlorpyrifos-oxon (3 mg/kg, ip; once; wild-type mice) treatment shows the dimensions of microtubules from Chlorpyrifos-oxon-treated mice are about 60% of those from control mice. The microtubules from mice exposed to Chlorpyrifos-oxon have covalently modified amino acids and abnormal structure, suggesting disruption of microtubule function.
氯吡硫磷一氧
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氯吡硫磷一氧
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5598-15-2, 氯吡硫磷一氧 相关搜索:
- Phosphorylating and Phosphitylating Agents
- Pharmaceuticals
- Metabolites & Impurities
- Intermediates & Fine Chemicals
- Heterocycles
- 杀虫剂
- 有机氯杀虫剂
- 标准品
- C9H11Cl3NO4P
- 毒死蜱杂质标样A
- 毒死蜱氧化物(5598-15-2) 标准品
- 毒死蜱氧化物 标准品
- 氯吡硫磷一氧
- 毒死碑代谢物
- 毒死蜱氧化物
- 5598-15-2
- Chlorpyrifos Impurity 2（Chlorpyrifos Oxon）
- Chlorpyrifos-oxon @100 μg/mL in Methanol
- Phospyrat ethyl
- phosphoricacid,diethyl3,5,6-trichloro-2-pyridylester
- phosphoricacid,diethyl3,5,6-trichloro-2-pyridinylester
- Phosphoric acid, diethyl 3,5,6-trichloro-2-pyridinyl ester
- o,o-diethylo-3,5,6-trichloro-2-pyridylphosphate
- Fospirate-ethyl
- dursbanoxygenanalog
- Dursbanoxon
- Dursban oxygen analog
- Dursban O-analog
- Diethyl 3,5,6-trichloro-2-pyridyl phosphate
- Diethyl 3,5,6-trichloro-2-pyridinyl phosphate
- chlorpyrifosoxygenanalog
- chloropyrifosoxygenanalog
- CHLORPYRIFOS OXON STANDARD
- CHLORPYRIPHOXON
- CHLORPYRIFOXON
- diethyl (3,5,6-trichloropyridin-2-yl) phosphate
- Phosphoric acid O,O-diethyl O-(3,5,6-trichloropyridin-2-yl) ester
- Phosphoric acid 3,5,6-trichloro-2-pyridyldiethyl ester
- CHLORPYRIFOS-OXON
- CHLORPYRIPHOS-O-ANALOGUE
- Chlorpyrifos-ethyl Oxon
- 6-Trichloro-2-pyridyl Diethyl Phosphate
- Chlorpyrifos Oxon 100mg [5598-15-2]
- chlorpyrifos oxygen analogue
- chloropyrifosoxon
- Chloropyrifos oxygen analog
- Chloropyrifos oxon
- 3,5,6-Trichloro-2-pyridyl diethyl phosphate