盐酸阿曲生坦
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- CAS号:
- 195733-43-8
- 英文名:
- Atrasentan hydrochloride
- 英文别名:
- ABT627;ABT-627;ABT 627;A 147627.1;Abbott 147627;Atrasentan HCl;Unii-E4G31X93za;ABT-627 hydrochloride;A-147627 hydrochloride;Atrasentan hydrochloride
- 中文名:
- 盐酸阿曲生坦
- 中文别名:
- 盐酸阿曲生坦;阿曲生坦盐酸盐;(2R,3R,4S)-4-(1,3-苯并二氧戊环-5-基)-1-[2-(二丁基氨基)-2-氧代乙基]-2-(4-甲氧基苯基)吡咯烷-3-羧酸盐酸盐;(2R,3R,4S)-4-(苯并[D][1,3]二氧杂环-5-基)-1-(2-(二丁基氨基)-2-氧乙基)-2-(4-甲氧基苯基)吡咯烷-3-羧酸盐酸盐
- CBNumber:
- CB82128704
- 分子式:
- C29H38N2O6.HCl
- 分子量:
- 547.08
- MOL File:
- 195733-43-8.mol
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盐酸阿曲生坦化学性质
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储存条件:
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under inert gas (nitrogen or Argon) at 2-8°C
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溶解度:
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Soluble in DMSO
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形态:
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Powder
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InChIKey:
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IJFUJIFSUKPWCZ-FZVADPAUNA-N
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SMILES:
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C1(=CC2=C(OCO2)C=C1)[C@@H]1[C@@H](C(=O)O)[C@H](C2C=CC(OC)=CC=2)N(CC(N(CCCC)CCCC)=O)C1.Cl |&1:9,10,14,r|
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盐酸阿曲生坦性质、用途与生产工艺
盐酸阿曲生坦(ABT-627 hydrochloride) 是一种有效的选择性内皮素 A受体 (endothelin A receptor) 拮抗剂，抑制 ETA 的活性，IC50 值为 0.0551 nM。
Atrasentan hydrochloride (ABT-627 hydrochloride) (0-50 μM) significantly inhibits LNCaP and C4-2b prostate cancer cell growth. Atrasentan profoundly induces several CYPs and drug transporters (e.g. 12-fold induction of CYP3A4 at 50 μM). It is a moderate P-gp inhibitor (IC
50
in P388/dx cells=15.1±1.6 μM) and a weak BCRP inhibitor (IC
50
in MDCKII-BCRP cells=59.8±11 μM).
Atrasentan hydrochloride (ABT-627 hydrochloride) (3 mg/kg, p.o.) inhibits the pressor response induced by big endothelin-1 (1 nmol/kg) in pithed rats. Aatrasentan (ABT-627, 10 mg/kg, i.p.) inhibits the C4-2b tumor growth within the bone environment to some extent in the SCID-hu model.
盐酸阿曲生坦
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-15403A | Atrasentan hydrochloride | | 1 mg | 545元 |
| 2024/04/30 | HY-15403A | (2R,3R,4S)-4-(1,3-苯并二氧戊环-5-基)-1-[2-(二丁基氨基)-2-氧代乙基]-2-(4-甲氧基苯基)吡咯烷-3-羧酸盐酸盐
Atrasentan hydrochloride | 195733-43-8 | 5mg | 1184元 |
195733-43-8, 盐酸阿曲生坦 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Chiral Reagents
- Aromatics
- Amines
- C29H39ClN2O6
- C29H38N2O6HCl
- (2R,3R,4S)-4-(苯并[D][1,3]二氧杂环-5-基)-1-(2-(二丁基氨基)-2-氧乙基)-2-(4-甲氧基苯基)吡咯烷-3-羧酸盐酸盐
- 阿曲生坦盐酸盐
- 盐酸阿曲生坦
- (2R,3R,4S)-4-(1,3-苯并二氧戊环-5-基)-1-[2-(二丁基氨基)-2-氧代乙基]-2-(4-甲氧基苯基)吡咯烷-3-羧酸盐酸盐
- 195733-43-8
- A 147627,A-147627,(+)-A 127722,Atrasentan hydrochloride,Atrasentan,ABT627,ABT-627,Endothelin Receptor,ABT 627,Inhibitor,inhibit,A147627
- Atrasentan Hydrochloride，ABT627 HCl
- A-147627 hydrochloride
- (+)-A 127722 hydrochloride
- ABT-627 hydrochloride
- ABT-627; ABT627; ABT 627
- Atrasentan hydrochloride (ABT-627
- ABT-627; ABT627; ABT 627; ABBOTT 147627
- Atrasentan hydrochloride, CID 159595
- (2R,3R,4S)-4-(Benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride
- (2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride
- 3-Pyrrolidinecarboxylicacid,4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2R,3R,4S)-
- ABT-627
- ABT627
- ABT 627
- Unii-E4G31X93za
- Atrasentan hydrochloride [usan]
- Atrasentan HCl
- Abbott 147627
- A 147627.1
- 3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-, monohydrochloride, (2R,3R,4S)-
- Atrasentan hydrochloride