3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯
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- CAS号:
- 634911-80-1
- 英文名:
- 3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester
- 英文别名:
- abs818554;Caspase Inhibitor Boc-D-FMK;Caspase3-Inhibitor Boc-D-FMK;1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-;BOCDFMK,Inhibitor,inhibit,Caspase,Apoptosis,BOC D FMK;3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester;Pentanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-5-fluoro-4-oxo-, Methyl ester;BOC-D-FMK
(Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester)
- 中文名:
- 3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯
- 中文别名:
- 3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯
- CBNumber:
- CB82589624
- 分子式:
- C11H18FNO5
- 分子量:
- 263.26
- MOL File:
- 634911-80-1.mol
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3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯化学性质
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沸点:
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383.5±37.0 °C(Predicted)
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密度:
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1.150
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酸度系数(pKa):
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10.12±0.46(Predicted)
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3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯性质、用途与生产工艺
Boc-D-FMK 是可渗透细胞，不可逆的，泛半胱天冬酶 (caspase) 抑制剂。Boc-D-FMK 抑制 TNF-α 诱导的细胞凋亡的 IC50 值为 39 µM。
Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC
50
of 39 µM. BocD-fmk at 50 µM prevents genistein-induced apoptosis of p815 cells. Confocal microscopy shows that the release of mitochondrial apoptotic factors is inhibited by BocD-fmk.
Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle.
3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯
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3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯
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634911-80-1, 3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯 相关搜索:
- C11H18FNO5
- 3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯
- 634911-80-1
- BOCDFMK,Inhibitor,inhibit,Caspase,Apoptosis,BOC D FMK
- abs818554
- Caspase Inhibitor Boc-D-FMK
- 1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-
- BOC-D-FMK
(Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester)
- Pentanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-5-fluoro-4-oxo-, Methyl ester
- Caspase3-Inhibitor Boc-D-FMK
- 3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester