3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯
| 中文名称 | 3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯 |
|---|---|
| 中文同义词 | 3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯 |
| 英文名称 | 3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester |
| 英文同义词 | 3-[[(tert-Butoxy)carbonyl]amino]-5-fluoro-4-oxopentanoic acid methyl ester;Caspase3-Inhibitor Boc-D-FMK;Pentanoic acid, 3-[[(1,1-diMethylethoxy)carbonyl]aMino]-5-fluoro-4-oxo-, Methyl ester;BOC-D-FMK (Pentanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester);1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-;Caspase Inhibitor Boc-D-FMK;abs818554;BOCDFMK,Inhibitor,inhibit,Caspase,Apoptosis,BOC D FMK |
| CAS号 | 634911-80-1 |
| 分子式 | C11H18FNO5 |
| 分子量 | 263.26 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 634911-80-1.mol |
| 结构式 | ![3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯 结构式](CAS/GIF/634911-80-1.gif) |
3-[[叔丁氧羰基]氨基]-5-氟-4-氧代戊酸甲酯 性质
| 沸点 | 383.5±37.0 °C(Predicted) |
|---|---|
| 密度 | 1.150 |
| 酸度系数(pKa) | 10.12±0.46(Predicted) |
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Caspase
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Apoptosis is a pathway of cell death orchestrated by a family of proteases called caspases. Boc-D-fmk inhibits TNFα-stimulated reactive oxygen species (ROS) generation. Boc-D-FMK inhibits apoptosis stimulated by TNF-α with an IC 50 of 39 µM. BocD-fmk at 50 µM prevents genistein-induced apoptosis of p815 cells. Confocal microscopy shows that the release of mitochondrial apoptotic factors is inhibited by BocD-fmk.
Boc-D-FMK-fmk effectively attenuates the hepatocyte apoptosis in bile duct-ligated rats and may improve the survival rates after endotoxin challenge. A single injection of Boc-D-FMK results in longterm protection of MNs against root avulsion-induced death for more than 8 weeks and the Boc-D-FMK-treated MNs are able to regenerate their axons into an implanted PN graft and reinnervate the target muscle.