西奈芬净
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- CAS号:
- 58944-73-3
- 英文名:
- SINEFUNGIN
- 英文别名:
- SF;A-9145;rp32232;32232RP;SINEFUNGIN;Sinefungine;SCF from rat;Steel Factor;compound57926;A 9145, RP 32232
- 中文名:
- 西奈芬净
- 中文别名:
- 西奈芬近;西奈芬净;西奈芬净/D-GLYCERO-A-L-TALO-DECOFURANURONIC ACID,6,9-DIAMINO-1-(6-AMINO-9H-PURIN-9-YL)-1,5,6,7,8,9-HEXADEOXY-
- CBNumber:
- CB9167377
- 分子式:
- C15H23N7O5
- 分子量:
- 381.39
- MOL File:
- 58944-73-3.mol
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西奈芬净化学性质
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比旋光度:
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D25 -2.61° (c = 5 in water); D23 +12 ±2° (c = 0.227 in water)
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沸点:
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783.2±70.0 °C(Predicted)
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密度:
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1.91±0.1 g/cm3(Predicted)
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储存条件:
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2-8°C
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溶解度:
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H2O: soluble
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形态:
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powder
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酸度系数(pKa):
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pKa (66% DMF): 2.9, 3.9, 8.9, 10.2(at 25℃)
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颜色:
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white to yellow
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
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西奈芬净性质、用途与生产工艺
西奈芬净（9，sinefungin）是一种腺苷衍生物，属于泛甲基转移酶抑制剂，最初作为一种潜在的抗真菌药物从灰质链霉菌中分离出来。Hercik 等报道了西奈芬净与ZIKV甲基转移酶所形成配合物的晶体结构。SAM 为MTase 的天然底物，西奈芬净是其竞争性抑制剂。 西奈芬净与GTP 和GDP 类似物相结合，可能增强这些类似物对酶的亲和力，从而得到更好的选择性和对ZIKV 复制更强的抑制作用。然而，西奈芬净作为抗寄生虫剂在犬和山羊上进行实验时，被发现具有毒性，阻碍了其临床应用。
Sinefungin是病毒粒子mRNA (鸟嘌呤-7-)-甲基转移酶、 mRNA (核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。Sinefungin 是一种 SET7/9 抑制剂，通过抑制H3K4甲基化来改善肾纤维化。
Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA and inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells.
Western Blot Analysis
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Cell Line:
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Renal epithelial cells.
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Concentration:
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0.5 or 1.0 μg/mL.
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Incubation Time:
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Pretreatment 60 minutes before TGF-β1 (10 ng/mL).
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Result:
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Significantly reduced TGF-β1-inducedα-SMA protein expression and inhibited H3K4me1 in a dose-dependent manner in both NRK-52E and NRK-49F cells.
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Sinefungin (10 mg/kg, per day immediately after UUO) ameliorates renal fibrosis in obstructive nephropathy.
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Animal Model:
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Male C57BL/6J mice (8 weeks of age).
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Dosage:
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10 mg/kg
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Administration:
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Administered intraperitoneally per day immediately after UUO (prepared as a suspension in distilled water and 0.9% NaCl solution).
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Result:
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Inhibited α-SMA protein expression.
Ameliorated those (α-SMA, FSP-1, collagen 1, collagen 3) both at 3 and 7 days after UUO.
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西奈芬净
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-101938 | 西奈芬净
Sinefungin | 58944-73-3 | 1mg | 3000元 |
| 2024/04/30 | HY-101938 | Sinefungin | | 10 mM * 1 mLin Water | 3188元 |
西奈芬净
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58944-73-3, 西奈芬净 相关搜索:
- 药靶配体
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- Antibiotics N-S
- C15H23N7O5
- 西奈芬净/D-GLYCERO-A-L-TALO-DECOFURANURONIC ACID,6,9-DIAMINO-1-(6-AMINO-9H-PURIN-9-YL)-1,5,6,7,8,9-HEXADEOXY-
- 西奈芬近
- 西奈芬净
- 58944-73-3
- UUP,collagen 3,A 9145,inhibit,H3K4,Antibiotic,Sinefungin,α-SMA,FSP-1,Fungal,Inhibitor,A9145,Histone Methyltransferase,collagen 1
- SF
- Sinefungine
- D-glycero-a-L-talo-Decofuranuronic acid,6,9-diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-
- D-glycero-α-L-talo-Decofuranuronic acid, 6,9-diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-
- InSolution Sinefungin - CAS 58944-73-3 - Calbiochem
- (2S,5S)-2,5-Diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]hexanoic acid
- A 9145, RP 32232
- Sinefungin,5′-Deoxy-5′-(1,4-diamino-4-carboxybutyl)adenosine, A-9145, Adenosylornithine, Antibiotic 32232RP
- Antibiotic 32232RP
- 32232RP
- (2S,5S)-5-(5'-Adenosyl)-2,5-diaminopentanoic acid
- InSolution? Sinefungin
- 6,9-Diamino-1-(6-amino-9H-purin-9-yl)-1,5,6,7,8,9-hexadeoxy-D-glycero-α-L-talo-decofuranuronic acid
- Steel Factor
- Mast Cell Growth Factor (MGF)
- SCF from rat
- Kit ligand Precursor
- Anti-Foxp3 (C-terminal) antibody produced in rabbit
- ANTIBIOTIC A-9145
- A-9145
- ADENOSYLORNITHINE
- 5'-DEOXY-5'-(1,4-DIAMINO-4-CARBOXYBUTYL)ADENOSINE
- SINEFUNGIN
- rp32232
- compound57926
- 6,9-diamino-1-(6-amino-9h-purin-9-yl)-1,5,6,7,8,9-hexadeoxydecofuranuronica
- 6,9-diamino-1-(6-amino-9h-purin-9-d-glycero-alpha-l-talo-decofuranuronicaci
- 6,7,8,9-hexadeoxy-yl)-5