氰美马嗪
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- CAS号:
- 3546-03-0
- 英文名:
- cyamemazine
- 英文别名:
- TH-2602;RP-7204;Tercian;7204 RP;CiaMatil;Cianatil;CyaMeMazin;F. I. 6229;7204 R. E.;cyamemazine
- 中文名:
- 氰美马嗪
- 中文别名:
- 氰美马嗪;赛马咪嗪;西阿米嗪;赛马咪嗪杂质;氰美马嗪杂质;化合物 T15026;10-(3-(二甲基氨基)-2-甲基丙基)-10H-吩噻嗪-2-甲腈
- CBNumber:
- CB9914843
- 分子式:
- C19H21N3S
- 分子量:
- 323.46
- MOL File:
- 3546-03-0.mol
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氰美马嗪化学性质
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熔点:
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90-95°C
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-
沸点:
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bp0.2-0.5 205-220°
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密度:
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1.21±0.1 g/cm3(Predicted)
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储存条件:
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Refrigerator
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溶解度:
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DMSO: ≥5mg/mL
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酸度系数(pKa):
-
9.31±0.28(Predicted)
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形态:
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powder
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颜色:
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light yellow to yellow-green
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氰美马嗪性质、用途与生产工艺
Cyamemazine 是一种抗精神病药,其中含有吩噻嗪发色团,通常被用作抗焦虑药。Cyamemazine 是具有抗精神病活性的有效的 5-HT3 (Ki 为 12 nM), 5-HT2A (Ki 为 1.5 nM) 和 5-HT2C (Ki 为 75 nM) 受体拮抗剂。
5-HT
2A
Receptor
1.5 nM (Ki)
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5-HT
2C
Receptor
12 nM (Ki)
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5-HT
3
Receptor
75 nM (Ki)
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Cyamemazine exhibits a high affinity for dopamine receptors, which is consistent with its antipsychotic activity. The antagonist activity of Cyamemazine at muscarinic receptors is consistent with its affinity for M
1
(
K
i
= 13 nM), M
2
(
K
i
= 42 nM), M
3
(
K
i
= 321 nM), M
4
(
K
i
= 12 nM), and M
5
(
K
i
= 35 nM) receptors.
Cyamemazine behaves as an antagonist at the 5-HT
3
, 5-HT
2C
, and 5-HT
2A
receptors in 5-HT
3
-dependent contraction of isolated guinea pig ileum and bradycardic responses in rats, in 5-HT
2C
-dependent phospholipase C stimulation in the rat brain membrane, and in 5-HT
2A
-dependent contraction of isolated rat aorta rings and isolated guinea pig trachea. Cyamemazine antagonizes 5-HT
3
and 5-HT
2C
receptors and that this effect is partially involved in its therapeutic activity in anxiety disorders. Acute administration of low doses of Cyamemazine can reduces extracellular dopamine and metabolite concentrations in rat striatum.
氰美马嗪
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-14264 | 氰美马嗪 Cyamemazine | 3546-03-0 | 5mg | 800元 |
2024/04/30 | HY-14264 | 氰美马嗪 Cyamemazine | 3546-03-0 | 10 mM * 1 mLin DMSO | 880元 |
氰美马嗪
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氰美马嗪国内生产厂家
3546-03-0, 氰美马嗪 相关搜索:
- Sulfur & Selenium Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Amines
- 化工原料
- 10-(3-(二甲基氨基)-2-甲基丙基)-10H-吩噻嗪-2-甲腈
- 化合物 T15026
- 西阿米嗪
- 赛马咪嗪杂质
- 赛马咪嗪
- 氰美马嗪杂质
- 氰美马嗪
- 3546-03-0
- N-desmethyl cyamemazine maleateQ: What is
N-desmethyl cyamemazine maleate Q: What is the CAS Number of
N-desmethyl cyamemazine maleate Q: What is the storage condition of
N-desmethyl cyamemazine maleate
- 10H-Phenothiazine-2-carbonitrile, 10-[3-(dimethylamino)-2-methylpropyl]-
- Cyamepromazine
- cyamemazine
- 7204 RP
- 7204 R. E.
- Tercian
- F. I. 6229
- CyaMeproMezine
- CyaMeMazin
- CiaMatil
- 2-Cyano-10-(3-diMethylaMino-2-Methylpropyl)phenothiazine
- 10-[3-(DiMethylaMino)-2-Methylpropyl]-10H-phenothiazine-2-carbonitrile
- 10-[3-(dimethylamino)-2-methylpropyl]phenothiazine-2-carbonitrile
- 10-[3-(dimethylamino)-2-methyl-propyl]phenothiazine-2-carbonitrile
- TH-2602
- RP-7204
- Kyamepromazine
- Cianatil