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N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Struktur
1256490-31-9
CAS-Nr.
1256490-31-9
Englisch Name:
N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester
Synonyma:
EOS-61207;2. N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine;isopropyl((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)-L-alaninate;N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methyl...;N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl este;N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester;(S)-Isopropyl 2-(((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate;L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester
CBNumber:
CB22604354
Summenformel:
C18H21N2O7P
Molgewicht:
408.34
MOL-Datei:
1256490-31-9.mol
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N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Eigenschaften

Schmelzpunkt:
62-66℃
Siedepunkt:
514.3±60.0 °C(Predicted)
Dichte
1.302
storage temp. 
2-8°C
Löslichkeit
Dichloromethane, Ethyl Acetate, Methanol
pka
-5.78±0.70(Predicted)

Sicherheit

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl Ester is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Sofosbuvir

N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 43)Lieferanten
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  • N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-Methylethyl ester
  • L-Alanine, N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-, 1-Methylethyl ester
  • 2. N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine
  • N-[(S)-(4-nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methylethyl este
  • isopropyl((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)-L-alaninate
  • (S)-Isopropyl 2-(((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate
  • N-[(S)-(4-Nitrophenoxy)phenoxyphosphinyl]-L-alanine 1-methyl...
  • EOS-61207
  • 1256490-31-9
  • C18H21N2O7P
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