Isradipine
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- CAS-Nr.
- 75695-93-1
- Englisch Name:
- Isradipine
- Synonyma:
- Iomir;Lomir;Presca;CS-139;Prescal;Esradin;Rebfiden;Clivoten;DynaCirc;Dynacrine
- CBNumber:
- CB2268682
- Summenformel:
- C19H21N3O5
- Molgewicht:
- 371.39
- MOL-Datei:
- 75695-93-1.mol
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Isradipine Eigenschaften
- Schmelzpunkt:
- 166-1680C
- Siedepunkt:
- 501.9±60.0 °C(Predicted)
- Dichte
- 1.249±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: ~26 mg/mL
- Aggregatzustand
- solid
- pka
- 2.56±0.70(Predicted)
- Farbe
- yellow
- Merck
- 14,5240
- BCS Class
- 2/4
- Stabilität:
- Stable for 2 years from date of purchsae as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- HMJIYCCIJYRONP-UHFFFAOYSA-N
- CAS Datenbank
- 75695-93-1(CAS DataBase Reference)
- NIST chemische Informationen
- Isradipine(75695-93-1)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| S-Sätze: |
22-24/25 |
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| WGK Germany |
3 |
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| HS Code |
2934990002 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 4 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
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Isradipine Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
Isradipine is a long-acting calcium blocker effective in the treatment of essential
hypertension. The advantages of isradipine as compared with other dihydropyridine
calcium antagonists include a "gentle" onset and fewer contraindications. It can be taken
by patients with diabetes mellitus, chronic obstructive airway diseases, gout, congestive
heart failure or ischemic heart disease.
Chemische Eigenschaften
Yellow Solid
Verwenden
Isradipine is a L-type calcium channel blocker, Isradipine has anti-atherosclerotic effects in animals and improves endothelium-mediated nitric oxide (NO)-dependent vasodilation in vitro. Additional studies indicate that Isradipine may provide a neuroprotective effect in a rat model of focal ischemia and that Isradipine produces a dose-dependent sparing of dopamine neuronal fibers and cell bodies.
Allgemeine Beschreibung
Isradipine, 4-(4-benzofuranazyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester (DynaCirc), is another second-generationdihydropyridine-type channel blocker. This drug, like theother second-generation analogs, is more selective for vascularsmooth muscle than for myocardial tissue. It is effectivein the treatment of stable angina, reducing the frequencyof anginal attacks and the need to use nitroglycerin.
Biologische Aktivität
Potent and selective L-type voltage-gated Ca 2+ channel blocker. EC 50 and pA 2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca 2+ -induced contractions of rabbit aorta respectively; EC 25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo , exerting primary effects on vascular tissue with secondary negative chronotropic action.
Isradipine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Isradipine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 274)Lieferanten
75695-93-1()Verwandte Suche:
- PN-200-110
- Presca
- Prescal
- 4-(4-Benzofurazanyl)-2，6-dimethyl-1，4-dihydro-3，5-pyridinedicarboxylic acid methyl 1-methylethyl ester
- 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic [chemical name] acid methyl 1-methylethyl ester
- Dynacrine
- Iomir
- Rebfiden
- 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, methyl 1-methylethyl ester
- 4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-isopropyl ester
- PN-200-100
- [R,(-)]-4-(Benzofurazan-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester
- Isradipine
- Isradipin
- Clivoten
- DynaCirc
- Esradin
- Isrodipine
- Lomir
- 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylicacidmethyl1-methylethylester
- Isradipine (200 mg)
- 3-Methyl 5-propan-2-yl (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate
- Isradipine(Dynacirc)
- Isradipine API
- 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 3-methyl 5-(1-methylethyl) ester
- Isradipine, >=99%
- 3-Isopropyl 5-methyl 4-(benzo[c][1,2,5]oxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-di
- 4-(4-BENZOFURAZANYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER
- 4-(2,1,3-BENZOXADIAZOL-4-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECARBOXYLIC ACID METHYL 1-METHYLETHYL ESTER
- CS-139
- (4R)-4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-propan-2-yl ester
- Dynacirc CR
- PN 200-110;DYNACIRC; LOMIR; PRESCAL; DYNACIRC CR;
- Isradipine Solution, 100ppm
- Isradipine>
- Isradipine CRS
- 3,5-Pyridinedicarboxylic acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-(1-methylethyl) ester
- 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Isopropyl Methyl Ester
- Isopropyl Methyl 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimet
- Isopropyl Methyl 4-(4-Benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
- Isradipine USP/EP/BP
- Isradipine (PN 200-110)
- IsradipineQ: What is
Isradipine Q: What is the CAS Number of
Isradipine Q: What is the storage condition of
Isradipine Q: What are the applications of
Isradipine
- 4-(4-BChemicalbookenzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic[chemicalname]acidmethyl1-methylethylester
- Isradipine (1354207)
- Isopropyl methyl(±)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
- 75695-93-1
- 75696-93-1
- 75695-63-1
- C19H15N3O5D6
- ALLEGRA
- Ion Channels
- Calcium channel
- Intermediates & Fine Chemicals
- Pharmaceuticals
- API
