Chinese english Germany Japanese Korea

Zibotentan (ZD4054)

Zibotentan (ZD4054) Struktur
186497-07-4
CAS-Nr.
186497-07-4
Englisch Name:
Zibotentan (ZD4054)
Synonyma:
ZD454;Zd4054;CS-558;Zd 4054;Zibotentan;Zibotentan(ZD4054);zibotentan,CID 9910224;ZD4054;ZD-4054;ZD 4054;Zibotentan >=98% (HPLC);ZIBOTENTAN (ZD4054) 250MG
CBNumber:
CB31475871
Summenformel:
C19H16N6O4S
Molgewicht:
424.43
MOL-Datei:
186497-07-4.mol
Request For Quotation

Zibotentan (ZD4054) Eigenschaften

Schmelzpunkt:
239 - 241°C
Siedepunkt:
637.0±65.0 °C(Predicted)
Dichte
1.422
storage temp. 
Sealed in dry,Store in freezer, under -20°C
Löslichkeit
DMSO (Sparingly), Methanol (Slightly)
Aggregatzustand
Solid
pka
5.62±0.40(Predicted)
Farbe
White to Off-White
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

Zibotentan (ZD4054) Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Zibotentan is a selective antagonist of the endothelin (ET) receptor type A (IC50s = 21 and >10,000 nM for human recombinant ETA and ETB, respectively). It inhibits growth of HEY, OVCA 433, SKOV3, and A2780 cells induced by endothelin 1 (ET-1; ) in vitro. Zibotentan reduces ET-1-induced expression of MMP-2, MMP-9, VEGF, COX-1 and COX-2, mediators of cell invasion and angiogenesis, in HEY cells. In vivo, zibotentan (10-50 mg/kg per day) reduces tumor growth in an HEY mouse xenograft model in a dose-dependent manner. Formulations containing zibotentan are under clinical investigation for the treatment of ovarian and castration-resistant prostate cancers.

Verwenden

Zibotentan is a specific endothelin-A receptor antagonist that is a potential candidate in the treatment of prostate cancer, bone metastasis and various other types of cancer.

Zibotentan (ZD4054) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Zibotentan (ZD4054) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 86)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49391 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 27644 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739
 info@dycnchem.com CHINA 52861 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 24738 58
TargetMol Chemicals Inc. 		+1-781-999-5354
support@targetmol.com United States 19973 58
  • N-(3-METHOXY-5-METHYLPYRAZIN-2-YL)-2-[4-(1,3,4-OXADIAZOL-2-YL)PHENYL]PYRIDINE-3-SULFONAMIDE
  • 3-Pyridinesulfonamide, N-(3-methoxy-5-methylpyrazinyl)-2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-
  • Zd 4054
  • Zd4054
  • Zibotentan
  • Zibotentan(ZD4054)
  • N-(3-Methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-3-pyridinesulfonamide
  • 2-(4-(1,3,4-oxadiazol-2-yl)phenyl)-N-(3-Methoxy-5-Methylpyrazin-2-yl)pyridine-3-sulfonaMide
  • ZD454
  • ZIBOTENTAN (ZD4054);ZD4054;ZD-4054;ZD 4054
  • ZIBOTENTAN (ZD4054) 250MG
  • zibotentan,CID 9910224
  • ZD4054;ZD-4054;ZD 4054
  • CS-558
  • 3-Pyridinesulfonamide, N-(3-methoxy-5-methyl-2-pyrazinyl)-2-[4-(1,3,4-oxadiazol-2-yl)phenyl]-
  • Zibotentan >=98% (HPLC)
  • Zibotentan (ZD4054) USP/EP/BP
  • Zibotentan ZD4054 ZD-4054
  • 186497-07-4
  • C19H16N6O4S
  • Inhibitors
Copyright 2019 © ChemicalBook. All rights reserved