5,12-dihydroquinoxalino[2,3-b]quinoxaline

531-46-4

CAS-Nr.: 531-46-4

Englisch Name:: 5,12-dihydroquinoxalino[2,3-b]quinoxaline

Synonyma:: ML-090;Fluoflavine;5,12-dihydroquinoxalino[2,3-b]quinoxaline;6,11-dihydroquinoxalino[2,3-b]quinoxaline;Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro-;5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%);NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1

CBNumber:: CB31549066

Summenformel:: C14H10N4

Molgewicht:: 234.26

MOL-Datei:: 531-46-4.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 17

5,12-dihydroquinoxalino[2,3-b]quinoxaline Eigenschaften

Schmelzpunkt:: >262°C (dec.)

Siedepunkt:: 450.2±28.0 °C(Predicted)

Dichte: 1.43±0.1 g/cm3(Predicted)

storage temp.: -20°C Freezer

Löslichkeit: DMSO (Slightly, Heated, Sonicated)

Aggregatzustand: Solid

pka: 3.94±0.20(Predicted)

Farbe: Off-White to Dark Yellow

InChI: InChI=1S/C14H10N4/c1-2-6-10-9(5-1)15-13-14(16-10)18-12-8-4-3-7-11(12)17-13/h1-8H,(H,15,17)(H,16,18)

InChIKey: WGKYYZDYHYOKQV-UHFFFAOYSA-N

SMILES: N1C2=C(C=CC=C2)N=C2NC3=C(N=C12)C=CC=C3

Sicherheit

5,12-dihydroquinoxalino[2,3-b]quinoxaline Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NADPH oxidase 1 (NOX1) generates reactive oxygen species (ROS) in colon epithelial cells that interacts with both pathogenic and normal bacteria. Excess ROS production, however, is associated with damage to the intestinal mucosa, inflammatory bowel disease, and prostate cancer. ML-090 is the first identified NOX1-specific inhibitor (IC₅₀ = 360 nM in HEK293 cells) based on a quinoxaline scaffold that demonstrates potent selectivity over NOX2, NOX3, and NOX4 (IC₅₀s ≥ 10 μM) and xanthine oxidase (IC₅₀ = 3.5 μM).

Verwenden

5,12-Dihydroquinoxalino[2,3-b]quinoxaline is an inhibitor of?NADPH oxidase 1 (NOX1).

5,12-dihydroquinoxalino[2,3-b]quinoxaline Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5,12-dihydroquinoxalino[2,3-b]quinoxaline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 17)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai TenSus Biotechnology Co., Ltd.	021-50895067 18616507272	tensus@163.com	China	4207	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd	0431-80514535 19917294565	caoy@chemextension.com	China	2977	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	024-024-88590548 18341751992	757984502@qq.com	China	888	58

5,12-dihydroquinoxalino[2,3-b]quinoxaline
Fluoflavine
ML-090
Quinoxalino[2,3-b]quinoxaline, 5,11-dihydro-
5,12-Dihydroquinoxalino[2,3-b]quinoxaline (~90%)
6,11-dihydroquinoxalino[2,3-b]quinoxaline
NOX4,ML090,NADPH Oxidase,Inhibitor,NOX,HEK293 cell,NOX3,ML 090,NOX2,inhibit,ML-090,NOX1
531-46-4