Midazolam
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- CAS-Nr.
- 59467-70-8
- Bezeichnung:
- Midazolam
- Englisch Name:
- Midazolam
- Synonyma:
- 5-a)(1,4)benzodiazepine,8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo(;8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine;Midazolam;Midazolam-d;MidazolaM-d7;MidazolaM API;MIDAZOLAM,BP,EP;Midazolam (CRM);MidazolamBaseE.P;Midazolam solution
- CBNumber:
- CB3418581
- Summenformel:
- C18H13ClFN3
- Molgewicht:
- 325.77
- MOL-Datei:
- 59467-70-8.mol
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Midazolam Eigenschaften
- Schmelzpunkt:
- 161-164°C
- Siedepunkt:
- 496.9±55.0 °C(Predicted)
- Dichte
- 1.3136 (estimate)
- Flammpunkt:
- 9 °C
- storage temp.
- Controlled Substance, -20°C Freezer
- Löslichkeit
- Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent), soluble in methanol.
- Aggregatzustand
- Solid:crystalline
- pka
- pKa 1.7±0.1;6.15± 0.1 (Uncertain)
- Wasserlöslichkeit
- 54mg/L(24 ºC)
- BCS Class
- 1
- LogP
- 2.73
- CAS Datenbank
- 59467-70-8(CAS DataBase Reference)
- NIST chemische Informationen
- Midazolam(59467-70-8)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Midazolam Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Midazolam is the most commonly used parenteral sedative in anaesthetic practice. The structure of midazolam is altered by local changes in pH (tautomerism), and the two different forms confer either water or lipid solubility to the drug . At pH<4 the benzodiazepine nucleus opens because of an ionisable amine group in the molecule's structure, and this increases water solubility. At plasma pH the amine group is incorporated back into the unionised ring form of the molecule, which is highly lipid soluble and diffuses rapidly into the brain. A concentrated preparation (5mgml ?1 ) is available for i.m. injection and absorption is rapid compared with diazepam.
Chemische Eigenschaften
White Crystaline Solid
Verwenden
In many countries this product is controlled. An import permit may be required. Anesthetic; anticonvulsant; sedative; hypnotic
Allgemeine Beschreibung
Midazolam is a benzodiazepine, sold as Dormicum, Hypnovel
?, and Versed as a sedative and treatment for insomnia and seizures. This Snap-N-Spike
? Reference Solution is suitable for many GC/MS or LC/MS applications from clinical toxicology and urine drug testing to pain prescription monitoring or forensic analysis.
Pharmakokinetik
Midazolam undergoes hepatic oxidative metabolism and has an elimination half-life of 2–4h. The major metabolite is 1-hydroxymidazolam, which is biologically active. Midazolam has been used as a sole hypnotic for TI VA and produces superior procedural amnesia compared with propofol, but CSHT increases significantly when used by continuous infusion, and this delays recovery. Clinical studies demonstrate the inferiority of midazolam in terms of time to onset of desired sedation score, slower recovery, less clear-headedness, and significantly longer period of postoperative amnesia compared with propofol.
Midazolam Upstream-Materialien And Downstream Produkte
Upstream-Materialien
5-(2-chloroethyl)-2,3-dihydrobenzofuran
8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine 5-Oxide
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-
4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-3-[(4-methylphenyl)sulfonyl]-
8-Chlor-6-(o-fluorphenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-3-carbonsure
8-CHLORO-3A,4-DIHYDRO-6-(2-FLUOROPHENYL)-1-METHYL-3H-IMIDAZO[1,5-A][1,4]BENZO-DIAZEPINE
Midazolam EP Impurity J
7-Chlor-5-(2-fluorphenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-on
Methyljodid
Maleinsäure
Downstream Produkte
59467-70-8(Midazolam)Verwandte Suche:
- 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-α][1,4]benzodiazepine
- Midazolam
- MIDAZOLAM-D4 MALEATE
- 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
- Midazolam (base and/or unspecified salts)
- MidazolamBaseE.P
- 4H-Imidazo1,5-a1,4benzodiazepine, 8-chloro-6-(2-fluorophenyl)-1-methyl-
- MIDAZOLAM,BP,EP
- Methanol（Test Midazolam, 1.0 mg/mL）
- MidazolaM (CIV), BP, EP
- Midazolam CIV (300 mg)
- MidazolaM API
- MidazolaM-d7
- 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-benzo[f]imidazo[1,5-a][1,4]diazepine
- Midazolam solution
- Midazolam for system suitability
- Midazolam-d4 maleate solution
- Midazolam-d
- MidazolamNasalSpray(UCB)
- Midazolam (CRM)
- Midazolam USP/EP/BP
- Midazolam for system suitability (Y0000599)
- Midazolam D3Q: What is
Midazolam D3 Q: What is the CAS Number of
Midazolam D3 Q: What is the storage condition of
Midazolam D3 Q: What are the applications of
Midazolam D3
- MidazolamQ: What is
Midazolam Q: What is the CAS Number of
Midazolam Q: What is the storage condition of
Midazolam
- 5-a)(1,4)benzodiazepine,8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo(
- 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine
- 59467-70-8
- C18H10D3ClFN3
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
