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(3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion

CYCLO(-LEU-PRO) Struktur
2873-36-1
CAS-Nr.
2873-36-1
Bezeichnung:
(3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion
Englisch Name:
CYCLO(-LEU-PRO)
Synonyma:
gancidinw;Maculosin 6;Cyclo(Pro-Leu);CYCLO(-LEU-PRO);cyclo-l-leu-l-pro;Cyclo(L-Pro-D-Leu);Cyclo(L-Pro-L-Leu-);Cyclo(proline-leucine);Cyclo-L-prolyl-L-leucine;L-Leucyl-L-prolyl lactaM
CBNumber:
CB4142038
Summenformel:
C11H18N2O2
Molgewicht:
210.27
MOL-Datei:
2873-36-1.mol
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(3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion Eigenschaften

Schmelzpunkt:
163-165℃
Siedepunkt:
427.6±34.0 °C(Predicted)
Dichte
1.14
storage temp. 
Inert atmosphere,2-8°C
Löslichkeit
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
13.27±0.40(Predicted)
Farbe
White to Off-White
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Toxizität mouse,LD50,intravenous,80mg/kg (80mg/kg),"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1354, 1978.
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

(3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.

Chemische Eigenschaften

White Solid

Verwenden

Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.

Definition

ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.

(3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 84)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873
 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49391 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321
 info@finetechnology-ind.com China 9634 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10523 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439
 sales@nextpeptide.com China 19915 58
changzhou huayang technology co., ltd 		+8615250961469
 2571773637@qq.com China 9821 58
Chengdu Youngshe Chemical Co., Ltd. 		+8618108235634
 Cecilia@youngshechem.com China 2345 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49739 58

2873-36-1((3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion)Verwandte Suche:

(3S-trans)-Hexahydro-3-isobutylpyrrolo[1,2-a]pyrazin-1,4-dion
  • 2-a)pyrazine-1,4-dione,hexahydro-3-isobutyl-pyrrolo(stereoisomer
  • 4-dione,hexahydro-3-(2-methylpropyl)-2-a)pyrazine-(3s-trans)-pyrrolo(
  • cyclo-l-leu-l-pro
  • gancidinw
  • (3S-trans)-hexahydro-3-isobutylpyrrolo[1,2-a]pyrazine-1,4-dione
  • (3S,8aS)-2,3,6,7,8,8a-Hexahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione
  • (3S,8aS)-Octahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-leucyl-L-prolyl-)
  • CYCLO(-LEU-PRO)
  • Cyclo(L-Pro-L-Leu-)
  • 3-(2-methylpropyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • 3-isobutyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-quinone
  • (3S-trans)-Hexahydro-3-(2-Methylpropyl)-pyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-Pro-D-Leu)
  • Cyclo(Pro-Leu)
  • Cyclo(proline-leucine)
  • Cyclo-L-prolyl-L-leucine
  • L-Leucyl-L-proline lactaM
  • L-Leucyl-L-prolyl lactaM
  • Maculosin 6
  • (3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, (3S,8aS)-
  • Cyclo(-L-Leu-L-Pro)≥ 99% (TLC)
  • 3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-prolyl-L-leucyl)
  • 2873-36-1
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