Formoterol fumarate
|
|
|
- CAS-Nr.
- 43229-80-7
- Englisch Name:
- Formoterol fumarate
- Synonyma:
- Aformoterol;FORMOTEROL HEMIFUMARATE;YM 08316;FarMeterol;CGP 25827A;NSC 299587;CGP-25827A-e;Fumarate dihydrate;FORMAMIDE FUMARATE;FORADIL;FORMOTEROL
- CBNumber:
- CB5689602
- Summenformel:
- C42H52N4O12
- Molgewicht:
- 804.88
- MOL-Datei:
- 43229-80-7.mol
|
Formoterol fumarate Eigenschaften
- Schmelzpunkt:
- 138-140°C
- storage temp.
- Room temperature
- Löslichkeit
- Slightly soluble in water, soluble in methanol, slightly soluble in 2-propanol, practically insoluble in acetonitrile.
- pka
- pKa1 7.9; pKa2 9.2(at 25℃)
- Farbe
- White to off-white
- maximale Wellenlänge (λmax)
- 284nm(lit.)
- Merck
- 14,4245
- Stabilität:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| RIDADR |
3249 |
|
|
| RTECS-Nr. |
LQ2988000 |
|
|
| HazardClass |
6.1(b) |
|
|
| PackingGroup |
II |
|
|
| Toxizität |
LD50 in male, female, rats, mice (mg/kg): 3130, 5580, 6700, 8310 orally; 98, 100, 72, 71 i.v.; 1000, 1100, 640, 670 s.c.; 170, 210, 240, 210 i.p. (Yoshida) |
|
|
| Bildanzeige (GHS) |
 
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H300 |
Lebensgefahr bei Verschlucken. |
Akute Toxizität oral |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H370 |
Schädigt die Organe. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P307+P311, P321,P405, P501 |
| H373 |
Kann die Organe schädigen bei längerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizität (wiederholte Exposition) |
Kategorie 2 |
Warnung |
|
P260, P314, P501 |
| H412 |
Schädlich für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 3 |
|
|
P273, P501 |
|
| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P202 |
Vor Gebrauch alle Sicherheitshinweise lesen und verstehen. |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
|
Formoterol fumarate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Formoterol fumarate is a β2-selective adrenergic
agonist useful in the treatment of bronchial asthma.
It s potency and duration of action a r e reported to
exceed those of salbutamol, as is its ability to inhibit allergic and non-allergic histamine release.
Chemische Eigenschaften
Crystalline Solid
Verwenden
Formoterol fumarate is a potent β2-AR agonist.
Mechanism of action
This is believed to result from formoterol's greater water solubility, allowing it to get to the receptor sites faster, whereas its moderate lipophilicity keeps it in the lungs longer. It is indicated for the long-term maintenance treatment of asthma and for patients with symptoms of nocturnal asthma who require regular treatment with inhaled, short-acting, β2-agonists. It is not indicated for patients whose asthma can be managed by occasional use of inhaled, short-acting, β2-agonists. Formoterol is available only as a powder in a capsule for administration via the aerosolizer. Patients should be cautioned not to take the capsules orally and to keep them in a safe place to avoid accidental oral administration.
Clinical Use
Formoterol has a β-directing N-isopropyl-p-methoxyphenyl group and a unique m-formamide and p-hydroxyphenyl ring, which provides selectivity for β2-receptors. It is resistant to MAO and COMT, making it a long-acting agonist. Formoterol has a more rapid onset as compared to salmeterol while maintaining the same long duration of action.
Formoterol fumarate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Formoterol fumarate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 378)Lieferanten
43229-80-7()Verwandte Suche:
- formamide,n-(2-hydroxy-5-(1-hydroxy-2-((2-(4-methoxyphenyl)-1-methylethyl)amin
- o)ethyl)phenyl)-,(e)-2-butenedioate(2:1)(salt),dihydrate
- (+/-)-(R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]PHENYL] FORMAMIDE HEMIFUMARATE
- (R*,R*)-(+)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]-PHENYL]FORMAMIDE FUMARATE
- (R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2-(4-METHOXYPHENYL)-1-METHYLETHYL]AMINO]ETHYL]PHENYL]FORMAMIDE FUMARATE
- Formoterol fumarate JP13
- Formoterol fumarate 50 gram
- FORMATEROL FUMATATE
- FORMOTEROL FUMARATE, FOR SYSTEM SUITABILITY EP STANDARD
- FORMOTEROL FUMARATE, FOR IMPURITY D IDENTIFICATION EP STANDARD
- FORMOTEROL FUMARATE, EP STANDARD
- rel-N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide Fumarate Dihydrate
- Formoterol & Formoterol Fumarate
- FarMeterol
- ForMaterol FuMarate
- (R*,R*)-N-[2-HYDROXY-5-[1-HYDROXY-2-[[2
- ForMoterol FuMarate EP/USP
- ForMoterol FuMarate Dihydrate API
- N-(2-hydroxy-5-((S)-1-hydroxy-2-((S)-1-(4-methoxyphenyl)propan-2-ylamino)ethyl)phenyl)formamide hemifumaric acid
- Formoterol fumarate N-[2-Hydroxy-5-[[(1RS)-1-hydroxy-2-[[(1RS)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (E)-2-butenedioate
- CGP 25827A
- Eformoterol fumarate
- Formamide, N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, rel-, (2E)-2-butenedioate (2:1) (salt)
- Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-(+-)-, (E)-2-butenedioate (2:1) (salt)
- Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, (R*,R*)-, (E)-2-butenedioate (2:1) (salt)
- NSC 299587
- YM 08316
- FORMOTEROL FUMARATE
- n-[2-hydroxy-5-[[(1rs)-1-hydroxy-2-[[(1rs)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide (e)-2-butenedioate
- BD-40A, Atock, Foradil, Oxeze
- Formoterol dihydrate fumarate
- Formoterol monohydrate hemifumarate salt, (R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate
- (R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate (2:1) salt
- CGP-25827A-e
- Fumarate dihydrate
- FORMAMIDE FUMARATE
- rel-N-(2-hydroxy-5-((R)-1-hydroxy-2-(((R)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide hemifumarate
- FORADIL;FORMOTEROL
- N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-(4-methoxyphenyl)-1-methylethyl]-amino]ethyl]phenyl]formamide
- Formoterol for impurity I identification CRS
- Formoterol fumarate for system suitability CRS
- Eformoterol Hemifumarate
- Formoterol fumarate USP/EP/BP
- Formoterol Fumarate Anhydrous
- Formoterol D6 fumarateQ: What is
Formoterol D6 fumarate Q: What is the CAS Number of
Formoterol D6 fumarate Q: What is the storage condition of
Formoterol D6 fumarate Q: What are the applications of
Formoterol D6 fumarate
- Formoterol FumarateQ: What is
Formoterol Fumarate Q: What is the CAS Number of
Formoterol Fumarate Q: What is the storage condition of
Formoterol Fumarate Q: What are the applications of
Formoterol Fumarate
- Formoterol for impurity I identification (Y0000339)
- Aformoterol
- FORMOTEROL HEMIFUMARATE
- Formoterol fumerate dihydrate
- Formoterol Furoate
- 43229-80-7 Formoterol Fumarate
- N-(2-hydroxy-5-((S)-1-hydroxy-2-(((S)-1-(4-methoxyphenyl)propan-2-yl)amino)ethyl)phenyl)formamide fumarate
- Sialyllactose Impurity 21
- Formoterol Fumarate Base
- 43229-80-7
- 13229-80-7
- 2C19H24N2O4C4H4O4
