7-KETOCHOLESTEROL

7-KETOCHOLESTEROL Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

7-keto Cholesterol is a bioactive sterol and a major oxysterol component of oxidized LDL. It is produced by oxidation of cholesterol via ethanol-mediated lipid peroxidation or photodamage as well as oxidation of 7-dehydro cholesterol by the cytochrome P450 (CYP) isoform CYP7A1. 7-keto Cholesterol inhibits CYP7A1 (IC₅₀ = ~1 μM). It induces activation and chemotaxis of retinal microglia as well as polarization to a pro-inflammatory state via NLRP3 inflammasome activation in vitro. Intraocular implantation of 7-keto cholesterol coated wafers increases ocular levels of VEGF, IL-1β, and GRO/KC, macrophage infiltration, and neovascularization in rat eye. Levels of 7-keto cholesterol in lipid deposits are increased in a variety of chronic diseases, including atherosclerosis, Alzheimer''s disease, and age-related macular degeneration.

Chemische Eigenschaften

Off-White Solid

Verwenden

A metabolite of Cholesterol

Definition

ChEBI: A cholestanoid that consists of cholesterol bearing an oxo substituent at position 7.

Allgemeine Beschreibung

7-ketocholesterol is a major oxidation product of cholesterol.

Sicherheitsprofil

Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes

7-KETOCHOLESTEROL Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

7-KETOCHOLESTEROL Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Aktin Chemicals, Inc.	028-85159085	info@aktinchem.com	CHINA	1025	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9020	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Shanghai Taopu Industrial Co., LTD	18018507602 15900573766	394643792@qq.com	China	3109	58
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	94838	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50
Chengdu Biopurify Phytochemicals Ltd.	+86-028-82633397 18982077548	cwb1@biopurify.cn	China	2376	60

566-28-9()Verwandte Suche:

---

• 7-KETOCHOLESTEROL
• 5-CHOLESTEN-3BETA-OL-7-ONE
• 3BETA-HYDROXY-5-CHOLESTEN-7-ONE
• Cholest-5-en-3beta-ol-7-one
• 3-hydroxy-5-cholestene-7-one
• (3-beta)-cholest-5-en-7-on
• 3-beta-hydroxy-cholest-5-en-7-on
• 3-HYDROXY-5-CHOLESTENE-7-ONE;7-KETOCHOLESTEROL
• 3-beta-hydroxycholest-5-en-7-one
• 7-oxo-cholestero
• sc4722
• Cholest-5-en-7-one, 3-hydroxy-, (3.beta.)-
• 3β-hydroxy-5-cholesten-7-one
• 5A-CHOLESTAN-3B-OL-7-ONE
• 3-hydroxy-10,13-dimethyl-17-(6-methylheptan-2-yl)-1,2,3,4,8,9,11,12,14,15,1 6,17-dodecahydrocyclopenta[a]phenanthren-7-one
• (3)-3-Hydroxycholest-5-en-7-one
• 3-Hydroxycholest-5-en-7-one
• Cholest-5-en-3-ol-7-one
• 3β-Hydroxy-5-cholesten-7-one, 7-Ketocholesterol
• 7-KetoC
• (3S,8S,9S,10R,13R,14S,17R)-17-[(1R)-1,5-dimethylhexyl]-3-hydroxy-10,13-dimethyl-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one
• (3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-one
• Cholest-5-en-7-one, 3-hydroxy-, (3b)-
• 7-Ketocholesterolk
• 7-Keto Cholesterol (~98%)
• 7-Ketocholesterol (Solution)
• Cholesterol 7-Keto
• Cholest-5-en-7-one, 3-hydroxy-, (3β)-
• Cholesterol Impurity 23
• 7-oxocholesterol
• 5-cholesten-3B-ol-7-one
• 5-cholesten-3β-ol-7-one
• Ketocholesterol
• 5-Cholesten-3β-ol-7-one
• HMG-CoA reductase,inhibit,7 Ketocholesterol,Endogenous Metabolite,Inhibitor,coronary artery disease,7-Ketocholesterol,7Ketocholesterol,cholesterol biosynthesis,orphan disease
• Cholester-3-hydroxy-5-en-7-one
• 566-28-9
• Lipids
• Cholesterol and Derivatives
• Sterols
• BioChemical
• Biochemicals and Reagents
• Intermediates & Fine Chemicals
• Pharmaceuticals
• Steroids