Terfenadin
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- CAS-Nr.
- 50679-08-8
- Bezeichnung:
- Terfenadin
- Englisch Name:
- Terfenadine
- Synonyma:
- seldane;Terfenadin;Cyater;Terdin;terfen;Terfex;Aldaban;mdl9918;rmi9918;Teldane
- CBNumber:
- CB7695393
- Summenformel:
- C32H41NO2
- Molgewicht:
- 471.67
- MOL-Datei:
- 50679-08-8.mol
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Terfenadin Eigenschaften
- Schmelzpunkt:
- 145-152 °C
- Siedepunkt:
- 572.76°C (rough estimate)
- Dichte
- 1.0488 (rough estimate)
- Brechungsindex
- 1.6310 (estimate)
- storage temp.
- 2-8°C
- Löslichkeit
- chloroform: soluble250 mg plus 5 ml of solvent, clear to very slightly hazy, colorless to faintly yellow
- pka
- pKa 9.21(H2O
t = 25
I = 0.025) (Uncertain)
- Farbe
- White to Off-White
- Wasserlöslichkeit
- 0.001 g/100 mL (30 ºC)
- CAS Datenbank
- 50679-08-8(CAS DataBase Reference)
- NIST chemische Informationen
- Seldane(50679-08-8)
Terfenadin Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
White Solid
Verwenden
Terfenadine has been used to study the role of histamine in itch related to proteinase-activated receptors (PARs) in mice. Terfenadine has also been used to block histamine receptor type 1 to study the pathogenesis of 2,4-dinitrobenzene sulfonic acid (DNBS)-induced ulcerative colitis in rats.
Weltgesundheitsorganisation (WHO)
The first clinically interesting histamine H-receptor1 antagonists
were introduced in the late 1940s and early 1950s. Several H-antihistaminics have
a similar cardiac effect to that seen with astemizole1 and terfenadine. Serious
cardiovascular adverse reactions have been reported when used concomitantly
with imidazole antifungals and macrolide antibiotics. See also under astemizole.
Biologische Aktivität
Histamine H 1 receptor antagonist. Also blocks hERG and K ATP channels (IC 50 values are 204 nM and 1.2 μ M respectively). Inhibits the delayed rectifier K + current (I Kr ) in guinea pig ventricular myocytes (IC 50 = 50 nM). Activity prolongs QT and induces Torsades de pointes (TdP); cardiotoxic in vivo .
Pharmakologie
Terfenadine not only differs from the other antihistamine drugs in its chemical structure,
but also in that its action begins within 1–2 h and last approximately 12 h, reaching its
peak of action in 3–4 h.
Terfenadin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Terfenadin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 206)Lieferanten
50679-08-8(Terfenadin)Verwandte Suche:
- TERFENADINE
- a-[4-(1,1-Dmethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol
- A1lerplus
- Triludma
- ALPHA-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINEBUTANOL
- 1-(p-tert-Butylphenyl)-4-(4'-(alpha-hydroxydiphenylmethyl)-1'-piperidyl)-butanol
- (R)-α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidine-1-butanol
- [R,(+)]-α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidine-1-butanol
- (S)-α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidine-1-butanol
- [S,(-)]-α-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidine-1-butanol
- α-(p-tert-Butylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidine-1-butanol
- Terfenadine (200 mg)
- Terfenadine, Seldane, Triludan, Teldane
- Terfenadine 5GR
- α-[4-(1,1-DMethylethyl)phenyl]-4-(hydroxydiphenylMethyl)-
- Trerfenadine
- Fexofenadine / MDL 16455
- 1-(4-(tert-Butyl)phenyl)-4-(4-(hydroxydiphenylmethyl)-piperidin-1-yl)butan-1-ol
- α-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol
- TERFENADINE(SUBJECTTOPATENTFREE)
- 1-Piperidinebutanol, a-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)- (9CI)
- a-(p-tert-Butylphenyl)-4-(a-hydroxy-a-phenylbenzyl)-1-piperidinebutanol
- dl-Terfenadine
- Histadin
- NSC 665802
- Racemic terfenadine
- 1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylmethyl)piperid-1-yl)butan-1-ol
- Terfenadine (Patent No Supply)
- 3-[2-Thienyl]-L-Alanine99.5%
- A3，5-Diethoxy Acetopheone
- 1-(4-tert-butylphenyl)-4-(4-(alpha-hydroxybenzhydryl)piperidino)-butan-1-ol
- 1-(4-tert-Butylphenyl)-4-(4-[hydroxy(diphenyl)methyl]-1-piperidinyl)-1-butanol
- 1-(p-tert-butylphenyl)-4-(4’-(alpha-hydroxydiphenylmethyl)-1’-piperidyl)-butan
- 1-Piperidinebutanol, alpha-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-
- 1-piperidinebutanol,alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmeth
- Aldaban
- Allerplus
- alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebu
- alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebuta
- alpha-(p-tert-butylphenyl)-4-(alpha-hydroxy-alpha-phenylbenzyl)-1-piperidinebu
- alpha-(p-tert-Butylphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinebutanol
- Cyater
- mdl9918
- MDL-9918
- Nebralin
- RMI 9918
- rmi9918
- rmi-9918
- Teldane
- Teldanex
- Terdin
- terfen
- terfenadina(inn-spanish)
- terfenadinum(inn-latin)
- Terfex
- Ternadin
- treludan
- Triludan
