Carnosine
- CAS No.
- 305-84-0
- Chemical Name:
- Carnosine
- Synonyms
- CARNOSINE;N-B-ALANYL-L-HISTIDINE;Carnosin;Dragosine;β-Ala-His;H-β-Ala-His-OH;β-Alanyl-L-histidine;BETA-ALANYL-L-HISTIDINE;N-BETA-ALANYL-L-HISTIDINE;n-2-m
- CBNumber:
- CB00125962
- Molecular Formula:
- C9H14N4O3
- Molecular Weight:
- 226.23
- MDL Number:
- MFCD00005207
- MOL File:
- 305-84-0.mol
- MSDS File:
- SDS
| Melting point | 253 °C (dec.) (lit.) |
|---|---|
| Boiling point | 367.84°C (rough estimate) |
| alpha | 20.9 º (c=1.5, H2O) |
| Density | 1.2673 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 21 ° (C=2, H2O) |
| storage temp. | -20°C |
| solubility | DMSO (Very Slightly), Water (Slightly) |
| form | crystalline |
| pka | 2.62(at 25℃) |
| color | White |
| Odor | at 100.00?%. odorless |
| Water Solubility | almost transparency |
| Merck | 14,1850 |
| BRN | 87671 |
| Stability | Stable, but may be heat sensitive - store cold. Incompatible with strong oxidizing agents. |
| InChIKey | CQOVPNPJLQNMDC-ZETCQYMHSA-N |
| LogP | -3.8 at 22℃ |
| CAS DataBase Reference | 305-84-0(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 8HO6PVN24W |
| NCI Drug Dictionary | carnosine |
| EPA Substance Registry System | L-Histidine, .beta.-alanyl- (305-84-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 2 |
| RTECS | MS3080000 |
| F | 3-10 |
| TSCA | Yes |
| HS Code | 29332900 |
| Toxicity | LD50 oral in mouse: > 14930mg/kg |
Carnosine price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C9625 | L-Carnosine ~99%, crystalline | 305-84-0 | 10mg | $15.84 | 2024-03-01 | Buy |
| Sigma-Aldrich | C9625 | L-Carnosine ~99%, crystalline | 305-84-0 | 5g | $134 | 2024-03-01 | Buy |
| TCI Chemical | A0222 | beta-Alanyl-L-histidine >98.0%(HPLC)(T) | 305-84-0 | 1g | $19 | 2024-03-01 | Buy |
| TCI Chemical | A0222 | beta-Alanyl-L-histidine >98.0%(HPLC)(T) | 305-84-0 | 5g | $55 | 2024-03-01 | Buy |
| Alfa Aesar | H65668 | beta-Alanyl-L-histidine, 95% | 305-84-0 | 5g | $49.65 | 2024-03-01 | Buy |
Carnosine Chemical Properties,Uses,Production
Biological Functions
Although it is well known that carnosine plays an important role in exercise performance and skeletal muscle homeostasis, its definitive role is still not established. Carnosine functions as a high-energy phosphate system comparable to the creatine/phosphocreatine system. In their experiments, Severin et al. demonstrated that carnosine plays a role in contractile function of skeletal muscle. In nerve-muscle preparation of frogs, it has been shown that the offset of the fatigue could occur during rhythmic nerve-stimulated muscle contractions if 10 mM of carnosine was added to the surrounding medium. This is also true for anserine[1].
General Description
Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It is found in high concentrations in the brain, muscle, and gastrointestinal tissues of humans and is present in all vertebrates. Carnosine has a number of beneficial antioxidant properties. For example, carnosine scavenges reactive oxygen species (ROS) as well as alpha-beta unsaturated aldehydes created by peroxidation of fatty acid cell membranes during oxidative stress. Carnosine can oppose glycation, and it can chelate divalent metal ions. Carnosine alleviates diabetic nephropathy by protecting podocyte and mesangial cells, and can slow down aging[1].
Biological Activity
Evidence from animal studies showed that carnosine supplementation may reduce body weight, blood pressure level, serum lipid levels, and atherosclerotic plaque instability, thus inhibiting the development and/or progression of hypertension and atherosclerosis. However, well controlled human clinical trials investigating the role of carnosine in preserving and improving cardiovascular health are still scarce. A randomized placebo-controlled trial reported that 4-month treatment with a dietary supplement containing cinnamon, chromium, and carnosine (1.2 g/day) decreased fasting blood glucose and increased fat-free mass in overweight or obese pre-diabetic subjects. Furthermore, other randomized controlled trial demonstrated that L-carnosine (500 mg/d), added to conventional therapy for six months, significantly improved cardiopulmonary exercise test and the 6-min walking test, but not left-ventricular ejection fraction in patients with chronic heart failure[1].
References
[1] Carnosine, Small but Mighty—Prospect of Use as Functional Ingredient for Functional Food Formulation. Antioxidants (Basel). 2021 Jul; 10(7): 1037. DOI: 10.3390/antiox10071037
Carnosine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | info@konochemical.com | China | 2995 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50002 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 326 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| Shanghai Getian Industrial Co., LTD | +86-15373193816 +86-15373193816 | mike@ge-tian.com | China | 274 | 58 |
| Shanghai Chinqesen Biotechnology Co., Ltd. | +86-16628886292 +86-19521323435 | sales2@qschem-pharma.com | China | 46 | 58 |
| Shanghai Yunao International Trade Co., Ltd | +8617621705551 | asdf@shanghaihg.cn | China | 265 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 | sales06@tgybio.com | China | 938 | 58 |
| henan kanbei chemical co.,ltd | +undefined-86-1523780-4566 +undefined15237804566 | henankanbeichemical@163.com | China | 511 | 58 |
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View Lastest Price from Carnosine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-07-25 | CARNOSINE
305-84-0
|
US $0.00 / g | 1g | 99% | 1000kg | henan kanbei chemical co.,ltd | |
 |
2022-10-25 | carnosine
9001-64-3
|
US $10.00 / KG | 1KG | 99% | Ex 20 tons | Hebei Anda Technology Co., LTD | |
 |
2022-04-05 | Carnosine
305-84-0
|
US $0.00 / KG | 0.01KG | 99% | 1 tons | Wuhan Godbullraw Chemical Co.,ltd |
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