ARM1
- CAS No.
- 68729-05-5
- Chemical Name:
- ARM1
- Synonyms
- ARM1;ARM-1 (ARM1);4-(4-Benzylphenyl)-1,3-thiazol-2-amine;2-Thiazolamine, 4-[4-(phenylmethyl)phenyl]-;Epoxide Hydrolase,ARM1,HCT-116 cells,Inhibitor,LTA4H,ARM-1,cytotoxic,positive control,Aminopeptidase,4BSA,inhibit,ARM 1
- CBNumber:
- CB03152553
- Molecular Formula:
- C16H14N2S
- Molecular Weight:
- 266.36
- MDL Number:
- MFCD01816130
- MOL File:
- 68729-05-5.mol
ARM1 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 15865 | ARM1 ≥95% | 68729-05-5 | 5mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 15865 | ARM1 ≥95% | 68729-05-5 | 10mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 15865 | ARM1 ≥95% | 68729-05-5 | 50mg | $477 | 2024-03-01 | Buy |
| Cayman Chemical | 15865 | ARM1 ≥95% | 68729-05-5 | 100mg | $834 | 2024-03-01 | Buy |
| Matrix Scientific | 135662 | 4-(4-Benzylphenyl)-1,3-thiazol-2-amine 95%+ | 68729-05-5 | 2.500g | $1266 | 2021-12-16 | Buy |
ARM1 Chemical Properties,Uses,Production
Description
Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-
Uses
Leukotriene A4 (LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro. ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 μM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 μM). ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4 hydrolase.[Cayman Chemical]
References
[1]. stsiapanava a, olsson u, wan m, et al. binding of pro-gly-pro at the active site of leukotriene a4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. proc natl acad sci u s a. 2014 mar 18;111(11):4227-32.
[2]. haeggstrm jz. leukotriene a4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene b4 biosynthesis. j biol chem. 2004 dec 3;279(49):50639-42.
[3]. snelgrove rj, jackson pl, hardison mt, et al. a critical role for lta4h in limiting chronic pulmonary neutrophilic inflammation. science. 2010 oct 1;330(6000):90-4.
ARM1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9767 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| Block Chemical Technology (Shanghai) Co., LTD | 021-20432219 13918097649 | li_jinfei@acblock-lab.com | China | 9562 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Jingmo (Xiamen) Biotechnology Co., Ltd | 13621943973 13515979683 | sales@jamxmpharmatech.com | China | 1079 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39997 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | Gsiyu@solarbio.com | China | 50471 | 58 |