BENZIODARONE
- CAS No.
- 68-90-6
- Chemical Name:
- BENZIODARONE
- Synonyms
- l2329;Dilaf;algocor;Vasilar;carofam;Corofam;amplivix;cardivix;2329labaz;Retrangor
- CBNumber:
- CB0330990
- Molecular Formula:
- C17H12I2O3
- Molecular Weight:
- 518.08
- MDL Number:
- MFCD00868246
- MOL File:
- 68-90-6.mol
- MSDS File:
- SDS
| Melting point | 167° |
|---|---|
| Density | 1.9173 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| color | Beige |
| Water Solubility | 5.881mg/L(20 ºC) |
| CAS DataBase Reference | 68-90-6 |
| FDA UNII | 75CL65GTYR |
| ATC code | C01DX04,C01DX54 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P501-P270-P264-P301+P310+P330-P405 | |||||||||
| HS Code | 2906.19.5000 | |||||||||
| NFPA 704 |
|
BENZIODARONE price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | E1290 | Benziodarone >98.0%(GC) | 68-90-6 | 1g | $121 | 2024-03-01 | Buy |
| TCI Chemical | E1290 | Benziodarone >98.0%(GC) | 68-90-6 | 5g | $425 | 2024-03-01 | Buy |
| TRC | B197860 | Benziodarone | 68-90-6 | 10mg | $150 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0010003 | BENZIODARONE 95.00% | 68-90-6 | 1MG | $157.5 | 2021-12-16 | Buy |
| AK Scientific | 0208BA | Benziodarone | 68-90-6 | 1g | $225 | 2021-12-16 | Buy |
BENZIODARONE Chemical Properties,Uses,Production
Originator
Amplivix,Sigma-Tau
Uses
Benziodarone is a uricosuric drug,it is used to effectively to control hyperuricemia in renal transplantation.
Definition
ChEBI: Benziodarone is an aromatic ketone.
Manufacturing Process
The starting product 2-ethyl-3-benzofuranyl p-hydroxyphenyl ketone
(benzaron) was prepared in 4 steps:
1. First step was a reaction of salicylic aldehyde with chloroacetone to produce
2-acetyl-1-benzofuran.
2. It was reduced by hydrazine hydrate in an alkaline medium by process of
Hyuang-Minlon, J.A.C.S., 1946, 68, 2487 to give 2-ethyl-1-benzofurane.
3. 2-Ethyl-3-(4-methoxybenzoyl)-1-benzofuran was obtained from 2-ethyl-1-
benzofuran and 4-methoxy-benzoylchloride in a presence of tin tetrachloride.
4. It was heated with pyridine hydrochloride at 200°-220°C to give 2-ethyl-3-
benzofuranyl p-hydroxyphenyl ketone (benzaron) as described in N.P.B.Hoi,
C.Beaudet; US Patent No. 3,012,042; Dec. 5, 1961.
Benzaron (1 part) was dissolved in a very slight excess of 3% caustic soda. To
this solution is gradually added a slight excess of iodine dissolved in a 25%
aqueous solution of potassium iodide. The resultant solution is acidified with a
20% solution of sodium bisulphite, centrifuged, washed with water and then
recrystallized in acetic acid to give of 2-ethyl-3-benzofuranyl 4-hydroxy-3,5-
diiodophenyl ketone. MP: 167°C.
Therapeutic Function
Coronary vasodilator, Uricosuric
Safety Profile
A poison bj7 intraperitoneal and intravenous routes. Moderately toxic by ingestion. A flammable liquid. When heated to decomposition it emits toxic vapors of I-.
BENZIODARONE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9634 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 19949 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28398 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23680 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23662 | 75 |