D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-
- CAS No.
- 119567-63-4
- Chemical Name:
- D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-
- Synonyms
- DIMETHYLSPHINGOSINE;N-Dimethylsphingosine;N,N-dimethylsphingenine;N,N-DIMETHYLSPHINGOSINE;SPHINGOSINE, N,N-DIMETHYL;DIMETHYL SPHINGOSINE (D18:1);Dimethyl-D-erythro-sphingosine;N,N-Dimethylsphingosine (d18:1);D-ERYTHRO-N,N-DIMETHYLSPHINGOSINE;N,N-DIMETHYLSPHINGOSINE, D-ERYTHRO
- CBNumber:
- CB0456649
- Molecular Formula:
- C20H41NO2
- Molecular Weight:
- 327.55
- MDL Number:
- MFCD00153960
- MOL File:
- 119567-63-4.mol
- MSDS File:
- SDS
| Boiling point | 447.2±45.0 °C(Predicted) |
|---|---|
| Density | 0.921±0.06 g/cm3(Predicted) |
| Flash point | 14 °C |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml). |
| form | Waxy solid/Clear oil |
| pka | 13.72±0.20(Predicted) |
| color | colorless |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| CAS DataBase Reference | 119567-63-4(CAS DataBase Reference) |
| FDA UNII | L9QRA71834 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H350 | |||||||||
| Precautionary statements | P201-P202-P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P308+P313-P370+P378-P403+P235-P405-P501 | |||||||||
| Hazard Codes | F | |||||||||
| Risk Statements | 11 | |||||||||
| Safety Statements | 7-16 | |||||||||
| RIDADR | UN 1170 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| NFPA 704 |
|
D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0311 | N,N-Dimethylsphingosine ≥98% (HPLC) | 119567-63-4 | 5mg | $110 | 2024-03-01 | Buy |
| Sigma-Aldrich | 310500 | N,N-Dimethylsphingosine | 119567-63-4 | 5mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 62575 | N,N-Dimethylsphingosine ≥98% | 119567-63-4 | 5mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 62575 | N,N-Dimethylsphingosine ≥98% | 119567-63-4 | 10mg | $131 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0311 | N,N-Dimethylsphingosine ≥98% (HPLC) | 119567-63-4 | 25mg | $442 | 2024-03-01 | Buy |
D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Chemical Properties,Uses,Production
Description
N,N-Dimethylsphingosine (119567-63-4) is a synthetic derivative of D-erythro-sphingosine (Cat.# 10-2287). Endogenous sphingolipid.1?Inhibits sphingosine kinase (IC50 = 5 μM).2?N,N-Dimethylsphingosine induces apoptosis in a variety of cell lines.3
Chemical Properties
Colourless to Light Yellow Oil
Uses
A general modulator of protein kinases.
Uses
D-erythro-N,N-Dimethylsphingosine is general modulator of protein kinases . D-erythro-N,N-Dimethylsphingosine is implicated in neuropathic pain.
Uses
N,N-Dimethylsphingosine is an inhibitor of sphingosine kinase (SPHK). It is a natural metabolite of sphingosine in some cancer cell lines and tissues. N,N-Dimethylsphingosine inhibited U937 cell SPHK with a Ki value of 3.1 μM. N,N-Dimethylsphingosine induces apoptosis, but it is not an inhibitor of protein kinase C.
Definition
ChEBI: N,N-dimethylsphingosine is a sphingoid that is sphingosine in which the two amino hydrogens are replaced by methyl groups. It has a role as a metabolite and an EC 2.7.1.91 (sphingosine kinase) inhibitor. It is an aminodiol, a sphingoid and a tertiary amino compound. It is functionally related to a sphingosine. It is a conjugate base of a N,N-dimethylsphingosine(1+).
General Description
Dimethyl Sphingosine (d18:1), also called as N,N-Dimethyl-d-erythro-sphingosine (DMS), is a natural sphingolipid metabolite. It is found in various tissues.
Biochem/physiol Actions
N,N-Dimethylsphingosine (DMS) is an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines. N,N-Dimethylsphingosine is a potent inhbitor of sphingosine kinase. DMS levels are elevated in the spinal cord, and contributes to allodynia, in a transected-nerve model of neuropathic pain.
References
1) Igarashi et al. (1990), A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells; J. Biol. Chem., 265 5385 2) Yatomi et al. (1996), N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets; Biochemistry, 35 626 3) Gude et al. (2008), Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal; FASEB J., 22 2629
D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Preparation Products And Raw materials
Raw materials
Preparation Products
D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28659 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18739 | 57 |
View Lastest Price from D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-08-12 | D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-
119567-63-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- D-ERYTHRO-SPHINGOSINE, N,N-DIMETHYL-
119567-63-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd