BAPTA-AM
- CAS No.
- 126150-97-8
- Chemical Name:
- BAPTA-AM
- Synonyms
- CS-968;BAPTA-AM;DAPTA-AM;BAPTA AM, >=98%;BAPTA/AM(BAPTA-AM);BAPTA, AM *CAS 126150-97-8*;BAPTA/AM;BAPTAAM;BAPTA AM;BAPTA-AM;BAPTA, AM *UltraPure Grade* *CAS 126150-97-8*;1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N,N-TETRAACETIC ACID ACETOXYMETHYL ESTER;Tetrakis(acetoxyMethyl) 1,2-Bis(2-aMinophenoxy)ethane-N,N,N',N'-tetraacetate
- CBNumber:
- CB0461324
- Molecular Formula:
- C34H40N2O18
- Molecular Weight:
- 764.68
- MDL Number:
- MFCD00036696
- MOL File:
- 126150-97-8.mol
| Melting point | 86-90°C |
|---|---|
| Boiling point | 796.1±60.0 °C(Predicted) |
| Density | 1.350±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in chloroform, dimethyl sulfoxide |
| form | powder |
| pka | 1.69±0.50(Predicted) |
| color | White |
| λmax | 287 nm |
| BRN | 7458534 |
| Stability | Light Sensitive |
| Biological Applications | Calcium indicators; treating cancer,chronic bacterial infection,glaucoma,ocular hypertension,HIV-associated conditions,infectious diseases,neurodegenerative disorders,neurological conditions,psychiatric conditions |
| InChIKey | YJIYWYAMZFVECX-UHFFFAOYSA-N |
| CAS DataBase Reference | 126150-97-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P271-P261-P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 8-10-21 | |||||||||
| HS Code | 2921490090 | |||||||||
| NFPA 704 |
|
BAPTA-AM price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A1076 | BAPTA-AM ≥95% (HPLC) | 126150-97-8 | 25mg | $281 | 2024-03-01 | Buy |
| Sigma-Aldrich | 196419 | BAPTA/AM - CAS 126150-97-8 - Calbiochem Membrane-permeable form of BAPTA. | 126150-97-8 | 25MG | $258 | 2024-03-01 | Buy |
| Sigma-Aldrich | 196419 | BAPTA/AM - CAS 126150-97-8 - Calbiochem Membrane-permeable form of BAPTA. | 126150-97-8 | 100mg | $619 | 2022-05-15 | Buy |
| TCI Chemical | T2845 | Tetrakis(acetoxymethyl) 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate | 126150-97-8 | 20MG | $117 | 2024-03-01 | Buy |
| TCI Chemical | T2845 | Tetrakis(acetoxymethyl) 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetate | 126150-97-8 | 200MG | $693 | 2024-03-01 | Buy |
BAPTA-AM Chemical Properties,Uses,Production
Description
BAPTA-AM is a selective, membrane-permeable calcium chelator.
Description
BAPTA-AM (126150-97-8) is a selective cell permeable Ca2+ chelator. It is a widely used intracellular calcium sponge.1,2 Rapidly taken up by cells where it is irreversibly hydrolyzed to BAPTA by intracellular esterases. Pretreatment of cells with BAPTA-AM inhibits thapsigargin-induced responses.3
Chemical Properties
Off-White to Light Yellow Solid
Uses
A cell permeable derivative of BAPTA which is widely used as an intracellular calcium sponge. Fluorescence: max. Abs. 287nm; e x 10-3: 5.9
Uses
BAPTA is membrane-impermeable calcium chelator that binds extracellular calcium ions (Kd = 0.11 μM), with selectivity over magnesium ions or protons. BAPTA and its derivatives can also be used as calcium indicators, since the absorption maximum for BAPTA changes when it is complexed with calcium (absorption maxima free/complexed = 254/274 nm, emission maxima free/complexed = 363/363 nm). BAPTA AM is a cell permeable analog of BAPTA that binds calcium only after the acetoxymethyl group is removed by cytoplasmic esterases. It is commonly used at 10-100 μM to evaluate the role of intracellular calcium in cell signaling. It can also be used in animals. BAPTA AM also inhibits voltage-gated potassium (Kv) channels, including Kv1.3, Kv1.5, and Kv11.1 (Ki = 1.45, 1.23, and 1.30 μM, respectively).
Uses
A membrane-permeable form of BAPTA;Selective chelator of intracellular Ca2+ stores.
Uses
BAPTA-AM is a lipophilic diester of BAPTA used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE. Fluorescence: max. Abs. 287nm; e x 10-3: 5.9
Definition
ChEBI: 2-[N-[2-(acetyloxymethoxy)-2-oxoethyl]-2-[2-[2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]anilino]acetic acid acetyloxymethyl ester is an alpha-amino acid ester.
General Description
BAPTA-AM inhibits free radical-mediated toxicity, enhances apoptosis in non-neuronal cells and protects neurons from ischemic damage. It regulates ion channels and blocks neuronal Ca2+-activated K+?channel currents. BAPTA-AM maintains intracellular Ca2+ homeostasis.
Biological Activity
Selective calcium chelator that is the cell-permeable analog of BAPTA (Cat No. 2786 ). Blocks hK v 1.5, hERG and hK v 1.3 channels (K i values are 1.23, 1.30 and 1.45 μ M respectively). Displays antithrombotic activity in vitro .
Biochem/physiol Actions
Selective chelator of intracellular Ca2+ stores.
storage
-20°C
References
1) Smith et al. (1992), Cytosolic calcium as a second messenger for collagen-induced platelet responses; Biochem. J., 288 925 2) Yoshida et al. (1993), Role of calcium ion in induction of apoptosis by etoposide in human leukemia HL-60 cells; Biochem. Biophys. Res. Commun., 196 927 3) Jiang et al. (1994), Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin; Exp. Cell Res., 212 84
BAPTA-AM Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from BAPTA-AM manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | BAPTA-AM
126150-97-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- BAPTA-AM
126150-97-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
tetrakis(acetoxymethyl ester) N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)Methoxy]-2-oxoethyl]glycine 1,1'-Bis[(acetyloxy)Methyl] Ester 1,2-Bis(2-aMinophenoxy)ethane-N,N,N`,N`-tetraacetic acid tetrakis(acetoxyMethyl ester), (BAPTA AM) Tetrakis(acetoxyMethyl) 1,2-Bis(2-aMinophenoxy)ethane-N,N,N',N'-tetraacetate Tetrakis(acetoxyMethyl) 2,2',2'',2'''-(((ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis(azanetriyl))tetraacetate 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N,N-TETRAACETIC ACID ACETOXYMETHYL ESTER(BAPTA-AM) BAPTA-AM 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl ester) BAPTA AM, >=98% BAPTA, AM ester [1,2- Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid, tetraacetoxymethyl ester] BAPTA/AM;BAPTAAM;BAPTA AM;BAPTA-AM CS-968 BAPTA/AM(BAPTA-AM) BAPTA, AM *CAS 126150-97-8* BAPTA, AM *UltraPure Grade* *CAS 126150-97-8* DAPTA-AM O,O'-Bis(2-aminophenyl)ethyleneglycol-N,N,N',N'-tetraacetic Acid, Tetraacetoxymethyl Ester 50mM/l Glycine, N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-, 1,1'-bis[(acetyloxy)methyl] ester 126150-97-8 C34H40N2O18 Intracellular Calcium Signaling BioChemical Cell Signaling and Neuroscience Calcium Signaling Research Tools Calcium Chelators Cell Biology Aromatic Inhibitors Chelating Agents & Ligands Fluorescent Labels & Indicators Amines Aromatics