ChemicalBook >> CAS DataBase List >>2',3',5'-Tri-O-acetyluridine
2',3',5'-Tri-O-acetyluridine
- CAS No.
- 4105-38-8
- Chemical Name:
- 2',3',5'-Tri-O-acetyluridine
- Synonyms
- TAU;Uridine triacetate;(2R,3R,4R,5R)-2-(AcetoxyMethyl)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate;MTBT1;MAPTL;RG 2133;Vistonuridine;2',3',5'-TriacetyL;Tri-O-acetyl uridine;2',3',5'-Tri-O-acety
- CBNumber:
- CB0687805
- Molecular Formula:
- C15H18N2O9
- Molecular Weight:
- 370.31
- MDL Number:
- MFCD00023795
- MOL File:
- 4105-38-8.mol
Last updated:2024-04-23 13:02:50
| Melting point | 127.0 to 131.0 °C |
|---|---|
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly) |
| form | Solid |
| pka | 9.39±0.10(Predicted) |
| color | Off-White |
| InChI | InChI=1S/C15H18N2O9/c1-7(18)23-6-10-12(24-8(2)19)13(25-9(3)20)14(26-10)17-5-4-11(21)16-15(17)22/h4-5,10,12-14H,6H2,1-3H3,(H,16,21,22)/t10-,12-,13-,14-/m1/s1 |
| InChIKey | AUFUWRKPQLGTGF-QRMSVCKNSA-N |
| SMILES | C(OC(=O)C)[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@H](OC(=O)C)[C@@H]1OC(=O)C |
| CAS DataBase Reference | 4105-38-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | uridine triacetate |
| FDA UNII | 2WP61F175M |
| NCI Drug Dictionary | uridine triacetate |
| ATC code | A16AX13 |
SAFETY
Risk and Safety Statements
| Safety Statements | 24/25 |
|---|---|
| WGK Germany | 3 |
| HS Code | 29349990 |
2',3',5'-Tri-O-acetyluridine price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SAB1306711 | ANTI-TAU(C-TERMINAL) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 4105-38-8 | 400μL | $481 | 2024-03-01 | Buy |
| Sigma-Aldrich | SAB1306682 | ANTI-TAU (MAPT) (S720) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution | 4105-38-8 | 400μL | $481 | 2024-03-01 | Buy |
| Sigma-Aldrich | S451738 | 2'',3'',5''-TRIACETYLURIDINE AldrichCPR | 4105-38-8 | 250MG | $179 | 2024-03-01 | Buy |
| TCI Chemical | T2549 | 2',3',5'-Tri-O-acetyluridine >98.0%(HPLC)(T) | 4105-38-8 | 5g | $28 | 2024-03-01 | Buy |
| TCI Chemical | T2549 | 2',3',5'-Tri-O-acetyluridine >98.0%(HPLC)(T) | 4105-38-8 | 25g | $90 | 2024-03-01 | Buy |
2',3',5'-Tri-O-acetyluridine Chemical Properties,Uses,Production
Description
Uridine triacetate is an orally available pro-drug of uridine approved by the FDA for the treatment of the rare autosomal recessive disorder called hereditary orotic aciduria. The drug was also approved for treating overdose of two chemotherapies (fluorouracil and capecitabine). Uridine triacetate was developed by Wellstat Therapeutics and licensed to BTG.
Chemical Properties
White or almost white crystalline powder
Uses
2’,3’,5’-Triacetyluridine is used in the treatment of Alzheimer’s disease in mice and provide neuroprotective effects. Shown to also decrease depressive symptoms and increases in brain pH bipolar patients.
Definition
ChEBI: Uridine triacetate is an acetate ester that is uracil in which the three hydroxy hydrogens are replaced by acetate group. A prodrug for uridine, it is used for the treatment of hereditary orotic aciduria and for management of fluorouracil toxicity. It has a role as a prodrug, a neuroprotective agent and an orphan drug. It is a member of uridines and an acetate ester.
Synthesis
Commercially available uridine (167) was treated with acetic
anhydride in the presence of catalytic boron trifluoride-etherate,
and the crude product was recrystallized from ethanol to give
uridine triacetate (XX) in 74-78% yield.
2',3',5'-Tri-O-acetyluridine Preparation Products And Raw materials
Global( 302)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhu Nuowei chemistry Co., Ltd. | +86-0553-2911116-802 +undefined17756524438 | sales1@nuowei-chem.com | China | 1642 | 58 |
| Hangzhou Measure Life Technology Co., LTD | +8613343730176 | 2924244016@qq.com | China | 83 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12471 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 3001 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15956 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
View Lastest Price from 2',3',5'-Tri-O-acetyluridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | uridine triacetate
4105-38-8
|
US $1.00 / KG | 1KG | 99.91% | 200000 | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-03-16 | 2',3',5'-Tri-O-acetyluridine
4105-38-8
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | |
 |
2023-07-01 | 2',3',5'-Tri-O-acetyluridine; Uridine Triacetate
4105-38-8
|
US $830.00-590.00 / kg | 1kg | 99% Purity (What/sapp: +86 18145728414) | 1000 Tons/Month | Guangzhou Tengyue Chemical Co., Ltd. |
-
- uridine triacetate
4105-38-8
- US $1.00 / KG
- 99.91%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- 2',3',5'-Tri-O-acetyluridine
4105-38-8
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
-
- 2',3',5'-Tri-O-acetyluridine; Uridine Triacetate
4105-38-8
- US $830.00-590.00 / kg
- 99% Purity (What/sapp: +86 18145728414)
- Guangzhou Tengyue Chemical Co., Ltd.
4105-38-8(2',3',5'-Tri-O-acetyluridine)Related Search:
2'', 3'', 5''-TRIACETYLURIDINE (2'', 3'', 5''-TRI-O-ACETYLURIDINE)
RG 2133
Tri-O-acetyl uridine
Vistonuridine
1-((2R,3R,4R,5R)-3,4-Diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
2',3',5'-Tri-O-acetyl-rU
1-((2R,3R,4R,5R)-3,4-Diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)tetrahydrofuran-2-yl)pyrimid
ANTI-TAU(C-TERMINAL) antibody produced in rabbit
MAPTL
Microtubule-associated protein tau
MTBT1
ANTI-TAU (MAPT) (S720) antibody produced in rabbit
[4-acetoxy-2-(acetoxymethyl)-5-(2,4-dioxopyrimidin-1-yl)tetrahydrofuran-3-yl] acetate
[4-acetyloxy-2-(acetyloxymethyl)-5-(
[4-acetyloxy-2-(acetyloxymethyl)-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl] acetate
2-(acetoxymethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
2-[(acetyloxy)methyl]-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
acetic acid [4-acetoxy-2-(acetoxymethyl)-5-(2,4-diketopyrimidin-1-yl)tetrahydrofuran-3-yl] ester
acetic acid [4-acetoxy-2-(acetoxymethyl)-5-(2,4-dioxo-1-pyrimidinyl)-3-tetrahydrofuranyl] ester
1-((2R,3R,4R,5R)-3,4-Diacetyl-3,4-dihydroxy-5-(1-hydroxy-2-oxopropyl)tetrahydrofuran-2-yl)pyri
(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4
2',3',5'-tri-O-Acetyluridine≥ 98% (HPLC)
URIDINE 2',3',5'-TRIACETATE
2',3',5'-TRI-O-ACETYLURIDINE
2',3',5'-TRIACETYLURIDINE
1-(2-O,3-O,5-O-Triacetyl-β-D-ribofuranosyl)-4-hydroxypyrimidine-2(1H)-one
[(2R,3R,4R,5R)-4-acetyloxy-2-(acetyloxymethyl)-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl] acetate
[(2R,3R,4R,5R)-4-acetyloxy-2-(acetyloxymethyl)-5-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl] ethanoate
acetic acid [(2R,3R,4R,5R)-4-acetoxy-2-(acetoxymethyl)-5-(2,4-diketopyrimidin-1-yl)tetrahydrofuran-3-yl] ester
2',3',5'-Tri-O-acety
[(2S,3R,4S,5S)-3,4-bis(acetyloxy)-5-(2,4-dioxo-1,2,3,4-tetrahydropyriMidin-1-yl)oxolan-2-yl]Methyl acetate
2',3',5'-Tri0acetyluridine
2`,3`,5`-Tracetyluridine
2',3',5'-Tri-O-acetyl-D-uridine
(Ser232) BioAssay&trade
Phospho-14-3-3 &theta
phosphorylated (S232)
2',3',5'-TriacetyL
2',3',5'-Tri-O-acetyluridine USP/EP/BP
Uridine triacetate
(2R,3R,4R,5R)-2-(AcetoxyMethyl)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate
TAU
Mouse Anti-Tau antibody
2',3',5'-Tri-O-acetyluridine
4105-38-8
4105-38-3
C15H18N2O9
Biochemicals and Reagents
BioChemical
Nucleoside Analogs
Nucleosides, Nucleotides, Oligonucleotides