ChemicalBook >> CAS DataBase List >>(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one

(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one

(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one structure

CAS No.: 139226-28-1

Chemical Name:: (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one

Synonyms: CS-490;darbufelone;(5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl);(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylide...;(Z)-2-AMino-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one;5-((z)-3,5-di-tert-butyl-4-hydroxybenzylidene)-2-imino-4-thiazolidinone;(5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one;(5z)-2-amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one;4(5H)-Thiazolone, 2-amino-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-, (5Z)-

CBNumber:: CB0855486

Molecular Formula:: C18H24N2O2S

Molecular Weight:: 332.46

MDL Number:

MOL File:: 139226-28-1.mol

Last updated:2023-09-04 15:50:00

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(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Properties

Boiling point	448.6±55.0 °C(Predicted)
Density	1.18±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	9.98±0.50(Predicted)
FDA UNII	72H8H6K34C

(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0021331	Darbufelone >98.0%	139226-28-1	1mg	$240	2021-12-16	Buy
American Custom Chemicals Corporation	API0005639	DARBUFELONE 95.00%	139226-28-1	5MG	$505.07	2021-12-16	Buy
American Custom Chemicals Corporation	API0005639	DARBUFELONE 95.00%	139226-28-1	100MG	$2047.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0021331	1mg	$240	Buy
API0005639	5MG	$505.07	Buy
API0005639	100MG	$2047.5	Buy

(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Chemical Properties,Uses,Production

Biological Activity

Darbufelone is a dual inhibitor of cellular PGF2α and LTB4 production. It potently inhibits PGHS-2 (IC50=0.19 μM), but is much less potent against PGHS-1 (IC50=20 μM).

in vivo

Darbufelone is a dual inhibitor of cellular PGF2R and LTB4 production. Darbufelone is orally active and nonulcerogenic in animal models of inflammation and arthritis.

target

IC50: 0.19 μM (PGHS-2), 20 μM (PGHS-1)

(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Suppliers

Global( 41)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	6010	61
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2127	70
Hunan Hui Bai Shi Biotechnology Co., Ltd.	0731-85526065 13308475853	ivy@hnhbsj.com	China	4550	62

Supplier	Advantage
Hangzhou FandaChem Co.,Ltd.	55
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Shanghai Boyle Chemical Co., Ltd.	55
Chembest Research Laboratories Limited	61
LGM Pharma	70
Hunan Hui Bai Shi Biotechnology Co., Ltd.	62

(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one Spectrum

(5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one(139226-28-1)¹HNMR

139226-28-1((5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one)Related Search:

Phenol Thiazole DARBUFELONE MESILATE (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one

(5z)-2-amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylidene]-1,3-thiazol-4-one 5-((z)-3,5-di-tert-butyl-4-hydroxybenzylidene)-2-imino-4-thiazolidinone (Z)-2-AMino-5-(3,5-di-tert-butyl-4-hydroxybenzylidene)thiazol-4(5H)-one darbufelone CS-490 (5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one 4(5H)-Thiazolone, 2-amino-5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-, (5Z)- (5Z)-2-Amino-5-[(4-hydroxy-3,5-ditert-butyl-phenyl)methylide... (5Z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl) 139226-28-1