Pyroxamide
- CAS No.
- 382180-17-8
- Chemical Name:
- Pyroxamide
- Synonyms
- NSC 696085;Pyroxamide;Pyroxamide PyroxaMide (NSC 696085);Pyroxamide ISO 9001:2015 REACH;N-Hydroxy-N'-3-pyridinyloctanediamide;N1-Hydroxy-N8-3-pyridinyl-octanediamide;n-hydroxy-n'-(pyridin-3-yl)octanediamide;Octanediamide, N1-hydroxy-N8-3-pyridinyl-;N1-Hydroxy-N8-(pyridin-3-yl)octanediamide
- CBNumber:
- CB0950394
- Molecular Formula:
- C13H19N3O3
- Molecular Weight:
- 265.31
- MDL Number:
- MFCD13194970
- MOL File:
- 382180-17-8.mol
- MSDS File:
- SDS
storage temp. | -20°C |
---|---|
solubility | DMSO: soluble10mg/mL (clear solution) |
form | powder |
color | white to beige |
NCI Dictionary of Cancer Terms | pyroxamide |
FDA UNII | 12N86DSS23 |
NCI Drug Dictionary | pyroxamide |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P280-P305+P351+P338 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 22 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
Pyroxamide price More Price(32)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML0296 | Pyroxamide ≥97% (HPLC) | 382180-17-8 | 5mg | $114 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0296 | Pyroxamide ≥97% (HPLC) | 382180-17-8 | 25mg | $407 | 2022-05-15 | Buy |
Cayman Chemical | 13870 | Pyroxamide ≥95% | 382180-17-8 | 5mg | $61 | 2024-03-01 | Buy |
Cayman Chemical | 13870 | Pyroxamide ≥95% | 382180-17-8 | 10mg | $107 | 2024-03-01 | Buy |
Cayman Chemical | 13870 | Pyroxamide ≥95% | 382180-17-8 | 25mg | $250 | 2024-03-01 | Buy |
Pyroxamide Chemical Properties,Uses,Production
Description
Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-
Uses
Pyroamide is a histone decetylase inhibitor (HDCi), a novel class of anti-neoplastic agent that acts by enhancing acetylation of histones, promoting uncoiling of chromatin and activation of genes implicated in the regulation of cell survival such as poliferation, differentiation and apoptosis. Pyroamide is known to potently inhibits affinity purified HDAC1. Also inhibits the growth of tumor cells in vitro and in vivo. Induces p21/WAF1 expression in tumor cells.
Uses
Pyroxamide is an inhibitor of histone deacetylases (HDACs), including HDAC1 (IC50 = 0.1-0.2 μM). It induces growth suppression and cell death of certain types of cancer cells in culture.
Definition
ChEBI: N'-hydroxy-N-(3-pyridinyl)octanediamide is an aromatic amide.
storage
-20°C
References
[1]. butler lm, webb y, agus db, et al. inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. clin cancer res, 2001, 7(4): 962-970.
[2]. kutko mc, glick rd, butler lm, et al. histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro. clin cancer res, 2003, 9(15): 5749-5755.
Pyroxamide Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27792 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
Hebei Duling International Trade Co. LTD | +8617333973358 | sales01@hbduling.cn | China | 15630 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
View Lastest Price from Pyroxamide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2022-11-23 | Pyroxamide
382180-17-8
|
US $0.50 / kg | 1kg | 0.99 | 20 | Hebei Duling International Trade Co. LTD | ||
2021-09-27 | Pyroxamide
382180-17-8
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | ||
2019-12-23 | Pyroxamide
382180-17-8
|
US $1.00 / KG | 1KG | 97%-99.9% | 100kg | Career Henan Chemical Co |
- Pyroxamide
382180-17-8
- US $0.50 / kg
- 0.99
- Hebei Duling International Trade Co. LTD
- Pyroxamide
382180-17-8
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
- Pyroxamide
382180-17-8
- US $1.00 / KG
- 97%-99.9%
- Career Henan Chemical Co