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2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2

CAS No.
729589-58-6
Chemical Name:
2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
Synonyms
2fLI;2-Fly;f-LIGRLO-NH2;2-f-LIGRLO-NH2;2F-LIGRLO-AMIDE;PAR-2 AGONIST II;2-Furoyl-LIGRLO-NH2;2-Furoyl-LIGRLO-amid;2-FUROYL-LIGRLO-AMIDE;2-(2-FUROYL)-LIGRLOAMIDE
CBNumber:
CB1382037
Molecular Formula:
C36H63N11O8
Molecular Weight:
777.95
MDL Number:
MFCD08460329
MOL File:
729589-58-6.mol
Last updated:2023-06-30 15:45:59

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Properties

Density 1.33±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in H2O
form powder
pka 12.91±0.46(Predicted)
color white
Water Solubility Soluble to 1 mg/ml in water

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F3681 2-Furoyl-LIGRLO-amide trifluoroacetate salt ≥97% (HPLC) 729589-58-6 1mg $171 2024-03-01 Buy
Alfa Aesar J66850 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 729589-58-6 1mg $70.5 2021-12-16 Buy
Alfa Aesar J66850 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 729589-58-6 5mg $258 2021-12-16 Buy
Cayman Chemical 14594 2-furoyl-LIGRLO amide ≥95% 729589-58-6 1mg $116 2024-03-01 Buy
Tocris 3015 2-Furoyl-LIGRLO-amide 729589-58-6 1 $132 2021-12-16 Buy
Product number Packaging Price Buy
F3681 1mg $171 Buy
J66850 1mg $70.5 Buy
J66850 5mg $258 Buy
14594 1mg $116 Buy
3015 1 $132 Buy

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Chemical Properties,Uses,Production

Uses

2-Furoyl-LIGRLO-amide trifluoroacetate salt may be used as a protease-activated receptor 2 (PAR2) agonist in endothelial progenitor cells (EPCs) and in transient receptor potential cation channel subfamily V member (TRPV4)-transfected HEK293t cells.

General Description

2-Furoyl-LIGRLO-amide trifluoroacetate salt is a peptide that acts as a proteinase-activated receptor-2 (PAR2) agonist, and contains a furoyl group addition at its N-terminal.

Biological Activity

potent and selective par2 receptor agonist (pd2 = 7.0). causes a dose-dependent relaxation of murine femoral arteries.

Biochem/physiol Actions

2-Furoyl-LIGRLO-amide is a potent and selective protease-activated receptor 2 (PAR2) agonist. PAR-2 activation is associated with increases in cAMP and intracellular Ca(2+). Immunoblot analysis revealed increases in phosphorylation of epidermal growth factor (EGF) receptor (EGFR) tyrosine kinase, Src, Pyk2, cRaf, and ERK1/2 in response to PAR-2 activation. 2-Furoyl-LIGRLO-amide is nearly 100-fold more potent than SLIGRL-NH2 (Cat. No. S9317). 2-Furoyl-LIGRLO-amide caused both an endothelium-dependent relaxation and an endothelium-independent contraction. It produced delayed (6 hours later) facilitation of capsaicin-evoked visceral nociception, an effect being much more potent than SLIGRL-NH2. Such effects were mimicked by i.col. trypsin. 2-f-LIGRL-NH2, coadministered repeatedly with caerulein six times in total, abolished the caerulein-evoked abdominal hyperalgesia/allodynia in WT, but not PAR2-KO, mice. Repeated doses of 2-f-LIGRL-NH2 moderately attenuated the severity of caerulein-induced pancreatitis in WT animals. It induced a similar dose-dependent increase in Ca2 levels in the presence and absence of b-arrestins.

storage

Store at -20°C

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 Suppliers

Global( 68)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd
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career henan chemical co
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BOC Sciences
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Zhejiang J&C Biological Technology Co.,Limited
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Alfa Chemistry
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Chengdu Youngshe Chemical Co., Ltd.
+8618108235634 Cecilia@youngshechem.com China 2345 58
Hebei Miaoyin Technology Co.,Ltd
+86-17367732028 +86-17367732028 kathy@hbyinsheng.com China 3582 58
Nanjing TGpeptide
+86-13347807150 +86-13347807150 support@tgpeptide.com China 3279 58
Zhejiang Hangyu API Co., Ltd
+8617531972939 anna@api-made.com China 2944 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33350 58

View Lastest Price from 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
	2-Furoyl-LIGRLO-amide trifluoroacetate salt pictures 2020-02-19 2-Furoyl-LIGRLO-amide trifluoroacetate salt
729589-58-6
US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co
	2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 pictures 2020-02-19 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2
729589-58-6
US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co

729589-58-6(2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2)Related Search:

PAR-2 AGONIST II PROTEINASE ACTIVATED RECEPTOR-2 AGONIST II 2-(2-FUROYL)-LEU-ILE-GLY-ARG-LEU-ORN-NH2 2-(2-FUROYL)-LIGRLOAMIDE 2-(2-FUROYL)-PAR-2 (2-6)-ORN AMIDE (MOUSE, RAT) 2F-LIGRLO-AMIDE 2-FUROYL-LEU-ILE-GLY-ARG-LEU-ORN-NH2 2-FUROYL-LIGRLO-AMIDE (2-Furoyl)-PAR-2 (2-6)-Orn amide (mouse, rat) 2fLI 2-f-LIGRLO-NH2 2-Fly 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2 trifluoroacetate salt 2-Furoyl-LIGRLO-amide trifluoroacetate salt f-LIGRLO-NH2 2-Furoyl-LIGRLO-NH2 Potent and Selective Protease-Activated Receptor 2 (PAR2) Agonist L-Ornithinamide, N-(2-furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl- N-(2-Furanylcarbonyl)-L-leucyl-L-isoleucylglycyl-L-arginyl-L-leucyl-L-ornithinamide 2-Furoyl-LIGRLO-amid 2-Furoyl-LIGRLO-NH2 Potent and Selective Protease-Activated Receptor2 (PAR2) Agonist 729589-58-6 C36H63N11O8