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TRIETHYL 4-PHOSPHONOCROTONATE

CAS No.
10236-14-3
Chemical Name:
TRIETHYL 4-PHOSPHONOCROTONATE
Synonyms
Ethyl 4-(diethoxyphosphoryl);TRIETHYL 4-PHOSPHONOCROTONATE;TRIETHYL 4-PHOSPHONO-2-BUTENOATE;triethyl trans-4-phosphono-2-butenoate;4-PHOSPHONOCROTONIC ACID TRIETHYL ESTER;Ethyl 4-(diethoxyphosphinyl)-2-butenoate;TRANS-ETHYL-4-(DIETHYLPHOSPHONO)CROTONATE;triethyl 4-phosphonocrotonate, cis + trans;(E)-Ethyl 4-(diethoxyphosphoryl)but-2-enoate;Ethyl (E)-4-(diethoxyphosphoryl)but-2-enoate
CBNumber:
CB1664375
Molecular Formula:
C10H19O5P
Molecular Weight:
250.23
MDL Number:
MFCD00009192
MOL File:
10236-14-3.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06

TRIETHYL 4-PHOSPHONOCROTONATE Properties

Boiling point 135 °C0.4 mm Hg(lit.)
Density 1.128 g/mL at 25 °C(lit.)
refractive index n20/D 1.455(lit.)
Flash point >230 °F
form Liquid
color Clear light yellow
CAS DataBase Reference 10236-14-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39-24/25
WGK Germany  3
HazardClass  IRRITANT
HS Code  29319090
NFPA 704
1
2 0

TRIETHYL 4-PHOSPHONOCROTONATE price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 116092 Triethyl 4-phosphonocrotonate, mixture of isomers technical grade, 90% 10236-14-3 10g $109 2024-03-01 Buy
Alfa Aesar A10995 Triethyl 4-phosphonocrotonate, cis + trans, 94% 10236-14-3 10g $91.65 2024-03-01 Buy
Alfa Aesar A10995 Triethyl 4-phosphonocrotonate, cis + trans, 94% 10236-14-3 25g $172.65 2024-03-01 Buy
Alfa Aesar A10995 Triethyl 4-phosphonocrotonate, cis + trans, 94% 10236-14-3 250g $1389 2021-12-16 Buy
AK Scientific 7628AC Triethyl4-phosphonocrotonate 10236-14-3 25g $263 2021-12-16 Buy
Product number Packaging Price Buy
116092 10g $109 Buy
A10995 10g $91.65 Buy
A10995 25g $172.65 Buy
A10995 250g $1389 Buy
7628AC 25g $263 Buy

TRIETHYL 4-PHOSPHONOCROTONATE Chemical Properties,Uses,Production

Chemical Properties

CLEAR LIGHT YELLOW LIQUID

Uses

Reactant for:

  • Iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase
  • Stereoselective preparation of C1-C19 fragment of macrolide antibiotic aplyronine A using diastereoselective Nozaki-Hiyama-Kishi coupling reactions
  • Orally bioavailable GPR40 agonist synthesis
  • Synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2
  • Preaparation of mGlu4R agonists
  • Dearomatizing cyclization of nicotinyl-substituted esters and ketones

Uses

Triethyl 4-phosphonocrotonate is used as a reactant for iminodipropionic acid as a leaving group for DNA polymerization by HIV-1 reverse transcriptase, orally bioavailable GPR40 agonist synthesis, preparation of mGlu4R agonists and synthesis of fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

6065-32-3
122-52-1
10236-14-3
Synthesis of TRIETHYL 4-PHOSPHONOCROTONATE from ethyl 4-bromocrotonate and Triethyl phosphite

TRIETHYL 4-PHOSPHONOCROTONATE Preparation Products And Raw materials

TRIETHYL 4-PHOSPHONOCROTONATE Suppliers

Global( 55)Suppliers
Supplier Tel Email Country ProdList Advantage
Career Henan Chemica Co
+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131981 58
Mainchem Co., Ltd. +86-0592-6210733 sale@mainchem.com China 32360 55
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 94838 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 021-61259108 18621169109 market03@meryer.com China 40240 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30132 84
Energy Chemical 021-021-58432009 400-005-6266 sales8178@energy-chemical.com China 44751 61
Shanghai Hanhong Scientific Co.,Ltd. China 42982 64
Syntechem Co.,Ltd info@syntechem.com China 12990 57
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123 sj_scrc@sinopharm.com China 9823 79
4-PHOSPHONOCROTONIC ACID TRIETHYL ESTER TRANS-ETHYL-4-(DIETHYLPHOSPHONO)CROTONATE TRIETHYL 4-PHOSPHONO-2-BUTENOATE TRIETHYL 4-PHOSPHONOCROTONATE TRIETHYL 4-PHOSPHONOCROTONATE, TECH., 90 %, MIXTURE OF ISOMERS Triethyl 4-phosphonocrotonate, predominantly trans, 92% triethyl 4-phosphonocrotonate, cis + trans triethyl 4-phosphonocrotonate, mixture of isomers triethyl trans-4-phosphono-2-butenoate Triethyl 4-phosphonocrotonate, cis + trans, tech. 90% Triethyl 4-phosphonocrotonate, 92%, predominantly trans (E)-Ethyl 4-(diethoxyphosphoryl)but-2-enoate Ethyl 4-(diethoxyphosphoryl)but-2-enoate, Ethyl 4-(diethylphosphono)crotonate Triethyl 4-phosphonocrotonate, predoMinantly trans, 92% 50GR Triethyl 4-phosphonocrotonate, mixture of isomers technical grade, 90% Triethyl 4-phosphonocrotonate, cis and trans, technical, 90% Ethyl 4-(diethoxyphosphoryl) 2-Butenoic acid, 4-(diethoxyphosphinyl)-, ethyl ester Ethyl (E)-4-(diethoxyphosphoryl)but-2-enoate Ethyl 4-(diethoxyphosphinyl)-2-butenoate 10236-14-3 C2H5O2POCH2CHCHCO2C2H5 C10H19O5P C-C Bond Formation Horner-Wadsworth-Emmons Reagents Olefination Synthetic Reagents C-C Bond Formation Horner-Wadsworth-Emmons Reagents Olefination