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Amprolium Hydrochloride

Amprolium Hydrochloride Structure
Amprolium Hydrochloride structure
CAS No.
137-88-2
Chemical Name:
Amprolium Hydrochloride
Synonyms
AMPROLIUM HCL;Amprolio;2-picolinium,1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-,chloride,monohydroc;amprol;amprol25;mepyrium;Amprovine;Ampomycin;CB2101848;thiacoccid
CBNumber:
CB2101848
Molecular Formula:
C14H20Cl2N4
Molecular Weight:
315.24
MDL Number:
MFCD00078831
MOL File:
137-88-2.mol
MSDS File:
SDS
Last updated:2024-04-26 17:21:34
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Amprolium Hydrochloride Properties

Melting point 239.0 to 243.0 °C
storage temp. Inert atmosphere,Room Temperature
solubility Methanol (Slightly), Water (Slightly)
form Powder
color White to Off-white
BRN 4118699
InChI InChI=1S/C14H19N4.2ClH/c1-3-6-13-16-9-12(14(15)17-13)10-18-8-5-4-7-11(18)2;;/h4-5,7-9H,3,6,10H2,1-2H3,(H2,15,16,17);2*1H/q+1;;/p-1
InChIKey PJBQYZZKGNOKNJ-UHFFFAOYSA-M
SMILES C1(C=NC(CCC)=NC=1N)C[N+]1C=CC=CC=1C.Cl.[Cl-]
CAS DataBase Reference 137-88-2(CAS DataBase Reference)
FDA UNII 95CO6N199Q
EPA Substance Registry System Amprolium hydrochloride (137-88-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P272-P280-P284-P302+P352-P333+P313
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
RTECS  TJ7565000
HS Code  29335995

Amprolium Hydrochloride price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 31592 Amprolium hydrochloride cationic 137-88-2 250mg $52.8 2024-03-01 Buy
Sigma-Aldrich 1034002 Amprolium United States Pharmacopeia (USP) Reference Standard 137-88-2 200mg $261.6 2024-03-01 Buy
TCI Chemical A2572 Amprolium Hydrochloride [for Biochemical Research] >98.0%(HPLC)(T) 137-88-2 5g $25 2024-03-01 Buy
TCI Chemical A2572 Amprolium Hydrochloride [for Biochemical Research] >98.0%(HPLC)(T) 137-88-2 25g $70 2024-03-01 Buy
Alfa Aesar J64782 1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium chloride 137-88-2 25g $90.2 2023-06-20 Buy
Product number Packaging Price Buy
31592 250mg $52.8 Buy
1034002 200mg $261.6 Buy
A2572 5g $25 Buy
A2572 25g $70 Buy
J64782 25g $90.2 Buy

Amprolium Hydrochloride Chemical Properties,Uses,Production

Description

Amprolium is a thiamine analog and antiprotozoal agent that interferes with thiamine metabolism and inhibits carbohydrate synthesis. It competitively inhibits thiamine uptake by E. tenella schizonts and by chick host intestinal cells (Kis = 7.6 and 326 μM, respectively). It also inhibits hexose formation and pentose utilization ex vivo in isolated lysed rat erythrocytes and in liver, kidney, heart, and intestinal tissue homogenates following dietary administration. Amprolium (1,000 ppm in feed) inhibits oocyst output and sporulation of Eimeria maxima, E. brunetti, and E. acervulina in infected chicks. It also decreases lesion and oocyst scores and mortality of E. tenella-infected chicks following dietary administration of a 125 ppm dose. Amprolium (100 μM) induces apoptosis in PC12 rat adrenal cells and increases the level of cleaved caspase-3. Formulations containing amprolium have been used as coccidiostats in poultry processing.

Chemical Properties

Crystalline powder

Uses

1-(4-Amino-2-n-propyl-5-pyrimidinylmethyl)-2-methylpyridinium Chloride is an antiparasytic drug used in the veterinary industry. In addition the compound shows anticoccidial activity.

Uses

Thiamine analog coccidiostat.

Uses

Coccidiostatic;Thiamine transport inhibitor

Definition

MeSH: Amprolium Hydrochloride is a veterinary coccidiostat that interferes with thiamine metabolism.

Contact allergens

Amprolium is an antiprotozoal agent used for the prevention of coccidiosis in poultry.

Veterinary Drugs and Treatments

Amprolium has good activity against Eimeria tenella and E. acervulina in poultry and can be used as a therapeutic agent for these organisms. It only has marginal activity or weak activity against E. maxima, E. mivati, E. necatrix, or E. brunetti. It is often used in combination with other agents (e.g., ethopabate) to improve control against those organisms.
In cattle, amprolium has approval for the treatment and prevention of E. bovis and E. zurnii in cattle and calves.
Amprolium has been used in dogs, swine, sheep, and goats for the control of coccidiosis, although there are no approved products in the USA for these species.

Amprolium Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Amprolium Hydrochloride Suppliers

Global( 403)Suppliers
Supplier Tel Email Country ProdList Advantage
shandong perfect biotechnology co.ltd
+86-53169958659; +8618596095638 sales@sdperfect.com China 294 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2503 58
Nantong Guangyuan Chemicl Co,Ltd 		+undefined17712220823 admin@guyunchem.com China 616 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618740459177 sarah@tnjone.com China 1107 58
Henan Suikang Pharmaceutical Co.,Ltd. 		+86-18239973690 +86-18239973690 sales@suikangpharm.com China 186 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21689 55
Hubei XinRunde Chemical Co., Ltd. 		+8615102730682 bruce@xrdchem.cn CHINA 566 55
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Supplier Advantage
shandong perfect biotechnology co.ltd
58
Henan Bao Enluo International TradeCo.，LTD 		58
Nantong Guangyuan Chemicl Co,Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Henan Suikang Pharmaceutical Co.,Ltd. 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hubei XinRunde Chemical Co., Ltd. 		55
Hefei TNJ Chemical Industry Co.,Ltd. 		55
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58

Related Qustion

View Lastest Price from Amprolium Hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Amprolium Hydrochloride pictures 2024-05-14 Amprolium Hydrochloride
137-88-2
 US $0.00 / kg 25kg 98.0%~101.0% 10tons Henan Suikang Pharmaceutical Co.,Ltd.
Amprolium Hydrochloride pictures 2024-05-08 Amprolium Hydrochloride
137-88-2
 US $100.00 / kg 1kg 99 10t Zibo Wei Bin Import & Export Trade Co. Ltd.
Amprolium Hydrochloride pictures 2024-04-24 Amprolium Hydrochloride
137-88-2
 US $0.00 / kg 1kg 99% 1000kg Shaanxi TNJONE Pharmaceutical Co., Ltd

Amprolium Hydrochloride Spectrum

Amprolium Hydrochloride(137-88-2)1HNMR

137-88-2(Amprolium Hydrochloride)Related Search:

Diclazuril Sulfaquinoxaline Spiramycin Maduramicin Dodecylpyridinium chloride
Chloromethane 1-((4-AMMONIO-2-METHYL-5-PYRIMIDINYL)METHYL)-2-METHYLPYRIDINIUM DICHLORIDE Amprolium Hydrochloride 5-PYRIMIDINEMETHANAMINE 1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium chloride
4-Pyrimidinamine, 2,5-dimethyl- (9CI) 5-Pyrimidinemethanamine, 2-methyl- (9CI) 4-Amino-5-aminomethyl-2-methylpyrimidine

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