ChemicalBook >> CAS DataBase List >>apogossypol
apogossypol
- CAS No.
- 66389-74-0
- Chemical Name:
- apogossypol
- Synonyms
- NSC736630;apogossypol;(+)-APOGOSSYPOL;APOGOSSYPOL;NSC736630;(+)Apogossypol,(+) Apogossypol;(+)-3,3'-Dimethyl-5,5'-bis(1-methylethyl)-2,2'-binaphthalene-1,1',6,6',7,7'-hexol;[2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-;3-methyl-5-propan-2-yl-2-(1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalene-1,6,7-triol
- CBNumber:
- CB21268526
- Molecular Formula:
- C28H30O6
- Molecular Weight:
- 462.53
- MDL Number:
- MOL File:
- 66389-74-0.mol
Last updated:2023-05-21 10:59:17
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
apogossypol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ApexBio Technology | B4902 | (+)-Apogossypol | 66389-74-0 | 5mg | $333 | 2021-12-16 | Buy |
| ApexBio Technology | B4902 | (+)-Apogossypol | 66389-74-0 | 10mg | $475 | 2021-12-16 | Buy |
| ApexBio Technology | B4902 | (+)-Apogossypol | 66389-74-0 | 10mM(in 1mL DMSO) | $490 | 2021-12-16 | Buy |
| CSNpharm | CSN18376 | (+)-Apogossypol | 66389-74-0 | 5mg | $336 | 2021-12-16 | Buy |
| Crysdot | CD31001130 | (+)-Apogossypol 98+% | 66389-74-0 | 10mg | $350 | 2021-12-16 | Buy |
apogossypol Chemical Properties,Uses,Production
Biological Activity
(+)-Apogossypol is a pan-BCL-2 antagonist that binds to Mcl-1, Bcl-2 and Bcl-xL with EC50 of 2.6, 2.8 and 3.69 μM, respectively.
in vitro
In agreement with NMR binding and fluorescence polarization assays (FPAs) data, (+)-Apogossypol displays potent binding affinity to Bcl-xL with K d values of 1.7 μM.
in vivo
Due to its modified structure, (+)-Apogossypol is expected to exhibit lower toxicity while maintaining the significant anti-growth and anti-tumor activities in vitro, similar to those of Gossypol.
target
| Mcl-1 < span> 2.6 μM (EC 50 ) | Bcl-2 2.8 μM (EC 50 ) | Bcl-xL 3.69 μM (EC 50 ) |
apogossypol Preparation Products And Raw materials
Raw materials
Preparation Products
apogossypol Suppliers
Global( 19)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6010 | 61 |
| Nanjing Peiwill Biotechnology Co.,Ltd. | 025-57027729 15850702895 | 15850702895@163.com | China | 72 | 55 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
View Lastest Price from apogossypol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-09-23 | apogossypol
66389-74-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- apogossypol
66389-74-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
apogossypol
(+)-3,3'-Dimethyl-5,5'-bis(1-methylethyl)-2,2'-binaphthalene-1,1',6,6',7,7'-hexol
NSC736630
APOGOSSYPOL;NSC736630
3-methyl-5-propan-2-yl-2-(1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalene-1,6,7-triol
(+)-APOGOSSYPOL
[2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-
(+)Apogossypol,(+) Apogossypol
66389-74-0