Company Name: |
Chembest Research Laboratories Limited
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021-20908456 |
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sales@BioChemBest.com |
Products Intro: |
Product Name:(+)-Apogossypol CAS:66389-74-0 Purity:98% HPLC Package:10mg;50mg;100mg;500mg;1g Remarks:Biochemical Reagents; Pharmaceutical Intermediates
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Company Name: |
Nanjing Peiwill Biotechnology Co.,Ltd.
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Tel: |
025-57027729 15850702895 |
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15850702895@163.com |
Products Intro: |
Product Name:apogossypol CAS:66389-74-0 Purity:97%HPLC Package:1g;10g;100g;1kg;100kg
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apogossypol manufacturers
- apogossypol
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- $0.00 / 1kg
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2022-09-23
- CAS:66389-74-0
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
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| apogossypol Basic information |
Product Name: | apogossypol | Synonyms: | apogossypol;(+)-3,3'-Dimethyl-5,5'-bis(1-methylethyl)-2,2'-binaphthalene-1,1',6,6',7,7'-hexol;NSC736630;APOGOSSYPOL;NSC736630;3-methyl-5-propan-2-yl-2-(1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalene-1,6,7-triol;(+)-APOGOSSYPOL;[2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-;(+)Apogossypol,(+) Apogossypol | CAS: | 66389-74-0 | MF: | C28H30O6 | MW: | 462.53 | EINECS: | | Product Categories: | | Mol File: | 66389-74-0.mol | |
| apogossypol Chemical Properties |
Melting point | 118-123 °C | Boiling point | 673.3±50.0 °C(Predicted) | density | 1.335±0.06 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | >16.2mg/mL in DMSO with gentle warming | form | Powder | pka | 8.03±0.50(Predicted) |
| apogossypol Usage And Synthesis |
Biological Activity | (+)-Apogossypol is a pan-BCL-2 antagonist that binds to Mcl-1, Bcl-2 and Bcl-xL with EC50 of 2.6, 2.8 and 3.69 μM, respectively. | in vitro | In agreement with NMR binding and fluorescence polarization assays (FPAs) data, (+)-Apogossypol displays potent binding affinity to Bcl-xL with K d values of 1.7 μM. | in vivo | Due to its modified structure, (+)-Apogossypol is expected to exhibit lower toxicity while maintaining the significant anti-growth and anti-tumor activities in vitro, similar to those of Gossypol. | target | Mcl-1 < span> 2.6 μM (EC 50 ) | Bcl-2 2.8 μM (EC 50 ) | Bcl-xL 3.69 μM (EC 50 ) | |
| apogossypol Preparation Products And Raw materials |
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