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apogossypol

apogossypol Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:(+)-Apogossypol;NSC736630;Apogossypol
CAS:66389-74-0
Purity:98.00% Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Henan Aochuang Chemical Co.,Ltd.
Tel: +86-0371-63689365 +8618638391208
Email: sales@aochuangchem.com
Products Intro: Product Name:apogossypol
CAS:66389-74-0
Purity:98% Package:1kg;USD|10kg;USD|25kg;USD
Company Name: Chembest Research Laboratories Limited  
Tel: 021-20908456
Email: sales@BioChemBest.com
Products Intro: Product Name:(+)-Apogossypol
CAS:66389-74-0
Purity:98% HPLC Package:10mg;50mg;100mg;500mg;1g Remarks:Biochemical Reagents; Pharmaceutical Intermediates
Company Name: Nanjing Peiwill Biotechnology Co.,Ltd.  
Tel: 025-57027729 15850702895
Email: 15850702895@163.com
Products Intro: Product Name:apogossypol
CAS:66389-74-0
Purity:97%HPLC Package:1g;10g;100g;1kg;100kg
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
Tel: 010-60605840 18892239720
Email: psaitong@jm-bio.com
Products Intro: Product Name:(+)-Apogossypol
CAS:66389-74-0
Package:100mg;250mg;500mg

apogossypol manufacturers

  • apogossypol
  • apogossypol pictures
  • $0.00 / 1kg
  • 2022-09-23
  • CAS:66389-74-0
  • Min. Order: 1kg
  • Purity: 98%
  • Supply Ability: 1Ton
apogossypol Basic information
Product Name:apogossypol
Synonyms:apogossypol;(+)-3,3'-Dimethyl-5,5'-bis(1-methylethyl)-2,2'-binaphthalene-1,1',6,6',7,7'-hexol;NSC736630;APOGOSSYPOL;NSC736630;3-methyl-5-propan-2-yl-2-(1,6,7-trihydroxy-3-methyl-5-propan-2-ylnaphthalen-2-yl)naphthalene-1,6,7-triol;(+)-APOGOSSYPOL;[2,2'-Binaphthalene]-1,1',6,6',7,7'-hexol, 3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2S)-;(+)Apogossypol,(+) Apogossypol
CAS:66389-74-0
MF:C28H30O6
MW:462.53
EINECS:
Product Categories:
Mol File:66389-74-0.mol
apogossypol Structure
apogossypol Chemical Properties
Melting point 118-123 °C
Boiling point 673.3±50.0 °C(Predicted)
density 1.335±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility >16.2mg/mL in DMSO with gentle warming
form Powder
pka8.03±0.50(Predicted)
Safety Information
MSDS Information
apogossypol Usage And Synthesis
Biological Activity(+)-Apogossypol is a pan-BCL-2 antagonist that binds to Mcl-1, Bcl-2 and Bcl-xL with EC50 of 2.6, 2.8 and 3.69 μM, respectively.
in vitroIn agreement with NMR binding and fluorescence polarization assays (FPAs) data, (+)-Apogossypol displays potent binding affinity to Bcl-xL with K d values of 1.7 μM.
in vivoDue to its modified structure, (+)-Apogossypol is expected to exhibit lower toxicity while maintaining the significant anti-growth and anti-tumor activities in vitro, similar to those of Gossypol.
target

Mcl-1

< span> 2.6 μM (EC 50 )

Bcl-2

2.8 μM (EC 50 )

Bcl-xL

3.69 μM (EC 50 )

apogossypol Preparation Products And Raw materials
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