4-(CHLOROMETHYL)-2-METHYLPYRIDINE
- CAS No.
- 75523-42-1
- Chemical Name:
- 4-(CHLOROMETHYL)-2-METHYLPYRIDINE
- Synonyms
- 4-(Chloromethyl)-2-picoline;2-Methyl-4-(chloromethyl)pyridine;4-(CHLOROMETHYL)-2-METHYLPYRIDINE;pyridine, 4-(chloroMethyl)-2-Methyl-;4-Chloromethyl-2-methyl-pyridine.HCL;2-methyl-pyridin-4-ylmethyl chloride;2-Methyl-4-(chloromethyl)pyridine (HCl)
- CBNumber:
- CB22454432
- Molecular Formula:
- C7H8ClN
- Molecular Weight:
- 141.6
- MDL Number:
- MFCD10697557
- MOL File:
- 75523-42-1.mol
- MSDS File:
- SDS
4-(CHLOROMETHYL)-2-METHYLPYRIDINE price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C369655 | 4-Chloromethyl-2-methylpyridine | 75523-42-1 | 5g | $1320 | 2021-12-16 | Buy |
| AccelPharmtech | D2223 | 4-(chloromethyl)-2-methyl-Pyridine 97.00% | 75523-42-1 | 1G | $2100 | 2021-12-16 | Buy |
| AccelPharmtech | D2223 | 4-(chloromethyl)-2-methyl-Pyridine 97.00% | 75523-42-1 | 5G | $3590 | 2021-12-16 | Buy |
| AccelPharmtech | D2223 | 4-(chloromethyl)-2-methyl-Pyridine 97.00% | 75523-42-1 | 25G | $6710 | 2021-12-16 | Buy |
4-(CHLOROMETHYL)-2-METHYLPYRIDINE Chemical Properties,Uses,Production
Uses
4-Chloromethyl-2-methylpyridine is used in the preparation of HIV-1 protease inhibitors.
Synthesis
4-(Chloromethyl)-2-methylpyridine is synthesised using (2-Methylpyridin-4-yl)methanol as a raw material by chemical reaction. The specific synthesis steps are as follows:
5-[(2-Chlorophenyl)acetylamino]-3-(4-fluorophenyl)-4-[4-(2-methylpyridyl)]isoxazole a) 4-Chloromethyl-2-methylpyridine; Into 100 mL of methylene chloride solution containing 2. 1-6 g of 4-(2-methylpyridyl)methanol (cf. PCT International Publication WO98/2120 Pamphlet), 23 mL of thionyl chloride was dropped at room temperature, followed by 20 hours' stirring at room temperature. The solvent was distilled off from the reaction solution under reduced pressure, and the residue was extracted with methylene chloride, after addition of saturated aqueous NaHCO3 solution. The methylene chloride extract was dried over anhydrous magnesium sulfate, and from which the solvent was distilled off under reduced pressure to provide 2.46 g (yield: 100%) of brown crystalline title compound. 1H-NMR(CDCl3)delta:8.45(d,J=5.0Hz,1H),7.31(s,1H), 7.25(d,J=5.0Hz,1H),4.74(s,2H),2.48(s,3H) Mass,m/e:141 (M+,base).
4-(CHLOROMETHYL)-2-METHYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Terma Medicare India Pvt.,Ltd | +8613916485955 | shivshanghai@yahoo.com | India | 138 | 58 |
| Cochemical Co. Ltd. | +86-029-86115547 +86-17791676824 | sales@cochemical.com | China | 3953 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Changzhou Hopschain Chemical Co.,Ltd. | 0519-85528066 13775048983 | sales@hopschem.com | China | 31557 | 55 |
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