N-PHENYL-4-[[(PHENYLAMINO)THIOXOMETHYL]AMINO]-BENZENESULFONAMIDE
![N-PHENYL-4-[[(PHENYLAMINO)THIOXOMETHYL]AMINO]-BENZENESULFONAMIDE Structure](CAS2/GIF/245342-14-7.gif)
- CAS No.
- 245342-14-7
- Chemical Name:
- N-PHENYL-4-[[(PHENYLAMINO)THIOXOMETHYL]AMINO]-BENZENESULFONAMIDE
- Synonyms
- LED209;CS-1789;LED209 hydrate;LED-209;LED 209;N-Phenyl-4-(3-phenylthioureido)benzenesulfonamide;LED 209,inhibit,Bacterial,LED209,LED-209,Inhibitor;N-Phenyl-4-(3-phenylthioureido)benzenesulfonamide LED209;N-PHENYL-4-[[(PHENYLAMINO)THIOXOMETHYL]AMINO]-BENZENESULFONAMIDE;Benzenesulfonamide, N-phenyl-4-[[(phenylamino)thioxomethyl]amino]-;N-phenyl-4-[[(phenylamino)thioxomethyl]amino]benzenesulfonamide hydrate
- CBNumber:
- CB22463973
- Molecular Formula:
- C19H17N3O2S2
- Molecular Weight:
- 383.49
- MDL Number:
- MFCD04086410
- MOL File:
- 245342-14-7.mol
- MSDS File:
- SDS
| Boiling point | 549.4±60.0 °C(Predicted) |
|---|---|
| Density | 1.437±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | insoluble in EtOH; insoluble in H2O; insoluble in DMSO |
| form | solid |
| pka | 8.77±0.10(Predicted) |
| FDA UNII | V62AG9LR2G |
N-PHENYL-4-[[(PHENYLAMINO)THIOXOMETHYL]AMINO]-BENZENESULFONAMIDE price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16844 | LED209 ≥98% | 245342-14-7 | 1mg | $16 | 2024-03-01 | Buy |
| Cayman Chemical | 16844 | LED209 ≥98% | 245342-14-7 | 5mg | $63 | 2024-03-01 | Buy |
| Cayman Chemical | 16844 | LED209 ≥98% | 245342-14-7 | 10mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 16844 | LED209 ≥98% | 245342-14-7 | 50mg | $469 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | INB0001197 | N-PHENYL-4-(((PHENYLAMINO)THIOXOMETHYL)AMINO)-BENZENESULFONAMIDE 95.00% | 245342-14-7 | 10MG | $739.2 | 2021-12-16 | Buy |
N-PHENYL-4-[[(PHENYLAMINO)THIOXOMETHYL]AMINO]-BENZENESULFONAMIDE Chemical Properties,Uses,Production
Biological Activity
many bacterial pathogens rely on a conserved membrane histidine sensor kinase, qsec, to respond to host adrenergic signaling molecules and bacterial signals in order to promote the expression of virulence factors. led209 is a potent prodrug that is highly selective for qsec.
in vitro
led209-mediated inhibition of virulence gene expression inhibited the secretion of espa and espb, two proteins encoded within the locus of enterocyte effacement that are required for escherichia coli (ehec) to translocate bacterial proteins into host cells and cause attaching-effacing (ae) lesions. at 5 pm, led209 abolished ehec ae lesion formation on cultured epithelial cells. unlike conventional antibiotics, led209 does not kill or hinder ehec growth or trigger the ehec sos response [1].
in vivo
led209 [20 mg per kilogram of body weight (mg/kg)] was given orally to mice 3 hours before and 3 hours after intraperitoneal injection of a lethal dose of s. typhimurium. twenty-four hours after infection, only 30% of untreated mice remained alive, whereas 80% of the led209-treated mice were still alive. all the s. typhimurium– infected mice died within 72 hours of infection, and 20% of led209-treated mice survived up to 12 days [1].
IC 50
<10 μm
References
[1] rasko da, moreira cg, li de r, reading nc, ritchie jm, waldor mk, williams n, taussig r, wei s, roth m, hughes dt, huntley jf, fina mw, falck jr, sperandio v. targeting qsec signaling and virulence for antibiotic development. science. 2008 aug 22;321(5892):1078-80.
N-PHENYL-4-[[(PHENYLAMINO)THIOXOMETHYL]AMINO]-BENZENESULFONAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-PHENYL-4-[[(PHENYLAMINO)THIOXOMETHYL]AMINO]-BENZENESULFONAMIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824 | bjkaida@163.com | China | 1627 | 59 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4182 | 55 |