Etodroxizine
- CAS No.
- 17692-34-1
- Chemical Name:
- Etodroxizine
- Synonyms
- UCB-1414;Etodroxine;Etodroxyzine;Etodroxizine;Hydroxyzine Impurity 2;Etodroxizine Impurities;Hydrochlorbenzethylamine;8-[4-[(4-Chlorophenyl)phenylmethyl]piperazin-1-yl]-3,6-dioxa-1-octanol;1-(p-Chlorobenzhydryl)-4-[2-[2-(2-hydroxyethoxy)ethoxy]ethyl]piperazine;2-[2-[2-[4-(p-Chloro-α-phenylbenzyl)-1-piperazinyl]ethoxy]ethoxy]ethanol
- CBNumber:
- CB31178673
- Molecular Formula:
- C23H31ClN2O3
- Molecular Weight:
- 418.96
- MDL Number:
- MFCD00867547
- MOL File:
- 17692-34-1.mol
| Boiling point | bp0.01 250° |
|---|---|
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | Solid |
| color | Off-White to Pale Beige |
| Stability | Hygroscopic |
| FDA UNII | CI1S3XAK7O |
Etodroxizine price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0011392 | ETODROXIZINE 95.00% | 17692-34-1 | 500MG | $329.7 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0011392 | ETODROXIZINE 95.00% | 17692-34-1 | 5G | $2136.75 | 2021-12-16 | Buy |
Etodroxizine Chemical Properties,Uses,Production
Originator
Vesparax,UCB Chemie,W. Germany,1973
Uses
Etodroxizine is a piperazine antihistimine.
Definition
ChEBI: Etodroxizine is a diarylmethane.
Manufacturing Process
A mixture of 1.5 mols of 1-(2'-hydroxyethyl)piperazine and 1 mol of pchlorobenzhydryl
chloride is heated at 150°C for 15 minutes. The substance is
dissolved in water, basified by caustic soda and extracted with benzene.
By purifying the benzene extract in vacuo, a 75% yield is obtained of 1-pchlorobenzhydryl-
4-(2'-hydroxyethyl)piperazine which has a boiling point of
205°C/0.02 mm Hg.
0.2 mol of 1-p-chlorobenzhydryl-4-(2'-hydroxyethyl)piperazine is dissolved in
300 cc of dry benzene and a solution of 36 grams of thionyl chloride in 100 cc
of dry benzene is added cold with agitation. Reflux heating is then carried out
until sulfur dioxide has ceased to be evolved.
The solvent is evaporated in vacuo, the residue is dissolved in anhydrous
acetone and the hydrochloride formed is filtered. The corresponding base is
liberated by treating the aqueous solution of this hydrochloride with an excess
of potassium carbonate. A benzene extraction is effected and the benzene
solution of the base is dried over potassium carbonate.
This benzene solution is then added to an equimolecular solution of the
monosodium derivative of diethyleneglycol in a considerable excess of
diethyleneglycol. The benzene is removed by distillation and the residue is
heated in a boiling water-bath with agitation for 3 hours
The excess diethyleneglycol is removed in vacuo and the residue dissolved in
water and then in benzene. The benzene extract is washed several times in
water, then purified in vacuo. The 1-p-chlorobenzhydryl-4-(2'-[2"-(2"'-
hydroxyethoxy)-ethoxy]-ethyl)piperazine obtained distills at 250°C/0.01 mm
Hg.
Therapeutic Function
Hypnotic
Hazard
Moderately toxic by ingestion.
Etodroxizine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9020 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55954 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |