Fosmidomycin
- CAS No.
- 66508-53-0
- Chemical Name:
- Fosmidomycin
- Synonyms
- Antibiotic FR-31705;10 Mg, 50 Mg, 100 Mg, 1g;Fosmidomycin sodium salt hydrate;3-Phosphono 1-(N-formylhydroxyamino)propane;3-(Formylhydroxyamino)propylphosphonic acid;(3-(N-hydroxyforMaMido)propyl)phosphonic acid;Phosphonic acid, P-[3-(formylhydroxyamino)propyl]-;(3-(N-Hydroxyformamido)propyl)phosphonic acid sodium salt
- CBNumber:
- CB31178815
- Molecular Formula:
- C4H10NO5P
- Molecular Weight:
- 183.1
- MDL Number:
- MFCD00865023
- MOL File:
- 66508-53-0.mol
| Melting point | 158-160° (dec); mp 160-166° (dec) (Hemmi) |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| FDA UNII | 5829E3D9I9 |
SAFETY
Risk and Safety Statements
| WGK Germany | 3 |
|---|---|
| Toxicity | LD50 in mice and rats (mg/kg): >11000 orally; ~8000 s.c. (Wiesner, 2003) |
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Fosmidomycin Chemical Properties,Uses,Production
Uses
Fosmidomycin sodium salt hydrate has been used as an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a study to determine monotropin carvacrol biosynthesis in Satureja khuzistanica plant.
Definition
ChEBI: Propylphosphonic acid in which one of the hydrogens at position 3 is substituted by a formyl(hydroxy)amino group. An antibiotic obtained from Streptomyces lavendulae, it specifically inhibits DXP reductoisomerase (EC 1.1.1.267), a key enzyme i the non-mevalonate pathway of isoprenoid biosynthesis.
Biochem/physiol Actions
Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) (MEP synthase): an antimalarial compound. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway).
Fosmidomycin Preparation Products And Raw materials
Raw materials
Preparation Products
Fosmidomycin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Suzhou Vosun Biotech Co.,Ltd | 0512-66569378-8002 66569378 | info@vosunchemical.com | China | 614 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18488 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 55 |
| Suzhou Vosun Biotech Co.,Ltd | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 58 |