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PD 98059

PD 98059 structure

CAS No.: 167869-21-8

Chemical Name:: PD 98059

Synonyms: 2-(2-AMINO-3-METHOXYPHENYL)-4H-CHROMEN-4-ONE;CS-398;PD090859;PD 98059;PD 098,059;PD 98059 NEW;PD 98059, 99+%;Amino chromone;PD 98059, >=98%;PD-98059/PD98059

CBNumber:: CB3256152

Molecular Formula:: C16H13NO3

Molecular Weight:: 267.28

MDL Number:: MFCD00671789

MOL File:: 167869-21-8.mol

MSDS File:: SDS

Last updated:2023-09-04 16:42:00

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PD 98059 Properties

Melting point	164～165℃
Boiling point	453.1±45.0 °C(Predicted)
Density	1.300±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	ethanol: 0.6 mg/mL
form	solid
pka	1.21±0.10(Predicted)
color	yellow
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey	QFWCYNPOPKQOKV-UHFFFAOYSA-N
CAS DataBase Reference	167869-21-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	SJE1IO5E3I

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312a-P330-P501a

Hazard Codes

Risk Statements

Safety Statements

22-60-36

RIDADR

UN 2811 6.1/PG 3

WGK Germany

HS Code

29322090

NFPA 704

	0
2		0

PD 98059 price More Price(65)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P215	PD 98,059 solid	167869-21-8	1mg	$78.6	2024-03-01	Buy
Sigma-Aldrich	513000	PD 98059 - CAS 167869-21-8 - Calbiochem	167869-21-8	5mg	$159	2024-03-01	Buy
Sigma-Aldrich	513001	InSolution? PD 98059	167869-21-8	1ml	$172	2024-03-01	Buy
Sigma-Aldrich	19-143	PD 98059	167869-21-8	5MG	$188	2024-03-01	Buy
Alfa Aesar	J64485	2'-Amino-3'-methoxyflavone, 99%	167869-21-8	10mg	$105.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
P215	1mg	$78.6	Buy
513000	5mg	$159	Buy
513001	1ml	$172	Buy
19-143	5MG	$188	Buy
J64485	10mg	$105.65	Buy

PD 98059 Chemical Properties,Uses,Production

Description

PD 98059 is a noncompetitive inhibitor of the MAPK pathway. It prevents the activation of MEK by Raf or MEK kinase (a MAP3K) with an IC₅₀ value of 2-7 μM but does not inhibit Raf-activated MAP2K1. It inhibits Raf activation of MAP2K2 with an IC₅₀ value of 50 μM. PD 98059 also phosphorylates and activates AMP-activated protein kinase (AMPK) in a dose-dependent manner (EC₅₀ = 35 μM in HEK293 cells). It increases the ratios of ADP to ATP and AMP to ATP and increases phosphorylation of the AMPK target acetyl-CoA carboxylase (ACC).

Uses

PD 98059 is a selective inhibitor of MEK and blocker of MAPK.

Definition

ChEBI: A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'

General Description

Selective, reversible, and cell-permeable inhibitor of MAP kinase kinase (MEK) that acts by inhibiting the activation of MAP kinase and subsequent phosphorylation of MAP kinase substrates. Pretreatment of PC-12 cells with PD 98059 completely blocks the 4-fold increase in MAP kinase activity produced by nerve growth factor (NGF; IC₅₀ = 2 μM); however, it has no effect on NGF-dependent tyrosine phosphorylation of the p140^trk receptor or its substrate Shc and does not block NGF-dependent activation of PI 3-kinase. Blocks LPS-induced activation of TNF-α gene expression. Inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. A 5 mg/ml solution of PD 98059 (Cat. No. 513001) in anhydrous DMSO is also available.

Biological Activity

Specific inhibitor of mitogen-activated protein kinase kinase (MAPKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC 50 = 2-7 μ M). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G 1 arrest by blocking p53-dependent p21 induction. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™ .

Biochem/physiol Actions

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

storage

Room temperature

References

1) Alessi et al. (1995), PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo; J. Biol. Chem., 270 27489 2) Dudley et al. (1995), A synthetic inhibitor of the mitogen-activated protein kinase cascade; Proc. Natl. Acad. Sci., 92 7686 3) Hotokezaka et al. (2002) U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells; J. Biol. Chem., 277 47366 4) Xiaoxia et al. (2004) BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways; Proc. Natl. Acad. Sci. USA 101 6027

PD 98059 Preparation Products And Raw materials

Raw materials

Preparation Products

PD 98059 Suppliers

Global( 211)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Hubei Ipure Biology Co., Ltd	58

View Lastest Price from PD 98059 manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-07-02	2-(2-aMino-3-Methoxyphenyl)-4H-chroMen-4-one 167869-21-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-09-02	InSolution PD 98059 167869-21-8	US $1.00-1.00 / KG	1KG	98%	1lg; 2kg; 5kg; 10kg; 100kg	Career Henan Chemical Co
2019-09-02	InSolution PD 98059 167869-21-8	US $1.00-1.00 / KG	1KG	98%	1lg; 2kg; 5kg; 10kg; 100kg	Career Henan Chemical Co

2-(2-aMino-3-Methoxyphenyl)-4H-chroMen-4-one
167869-21-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

InSolution PD 98059
167869-21-8
US $1.00-1.00 / KG
98%
Career Henan Chemical Co

InSolution PD 98059
167869-21-8
US $1.00-1.00 / KG
98%
Career Henan Chemical Co

PD 98059 Spectrum

PD 98059(167869-21-8)¹HNMR

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2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE 2-(2-AMINO-3-METHOXY-PHENYL)CHROMEN-4-ONE 2'-AMINO-3'-METHOXYFLAVONE PD 98059 in Solution PD 98059 PD 098,059 PD 098,059 (2-(2-AMINO-3-METHOXYPHENYL)- 4H-1-BENZOPYRAN-4-ONE PD 98059, 99+% 4H-1-Benzopyran-4-one, 2-(2-amino-3-methoxyphenyl)- 4H-1-Benzopyran-4-one,2-(2-amino-3-methoxyphenyl)-(9CI) PD090859 PD-98059/PD98059 2-(2-AMino-3-Methoxyphenyl)chroMone 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one PD 98059 PD 98059 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one PD 98059, >=98% InSolution? PD 98059 2-(2-Amino-3-methoxy-phenyl)chromen-4-one, 98%, a non-ATP competitive MEK inhibitor PD 98059 NEW CS-398 PD 98059 - NSC 679828 InSolution PD 98059 - CAS 167869-21-8 - Calbiochem PD 98059 - CAS 167869-21-8 - Calbiochem Amino chromone 2-(2-Amino-3-methoxyphenyl)chromone > PD 98059 USP/EP/BP 2-(2-AMINO-3-METHOXYPHENYL)-4H-CHROMEN-4-ONE PD 98059 (DMSO solution) 167869-21-8 C16H13O3N Specific inhibitor of the activation of mitogen-activated protein kinase kinase Mitogen-Activated Protein Kinase Kinase (MAPKK) Kinase/Phosphatase Biology Serine/Threonine Kinase Inhibitors BioChemical Cell Biology Cell Signaling and Neuroscience Inhibitors inhibitor MAPK Signalling pharmacetical Protein Kinase FLAVONE