PD 166793
- CAS No.
- 199850-67-4
- Chemical Name:
- PD 166793
- Synonyms
- PD 166793;PD-166793-0000;PD 166793 USP/EP/BP;MMP-2/MMP-3 Inhibitor;N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine;L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-;(S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid;(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci;(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
- CBNumber:
- CB3840520
- Molecular Formula:
- C17H18BrNO4S
- Molecular Weight:
- 412.3
- MDL Number:
- MFCD09038565
- MOL File:
- 199850-67-4.mol
- MSDS File:
- SDS
| Melting point | 192-193℃ |
|---|---|
| Density | 1.457 |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml |
| form | A crystalline solid |
| FDA UNII | U855L3SOXD |
PD 166793 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 444284 | MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem | 199850-67-4 | 5mg | $245 | 2024-03-01 | Buy |
| Cayman Chemical | 23762 | PD 166793 ≥98% | 199850-67-4 | 5mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 23762 | PD 166793 ≥98% | 199850-67-4 | 10mg | $171 | 2024-03-01 | Buy |
| Cayman Chemical | 23762 | PD 166793 ≥98% | 199850-67-4 | 25mg | $392 | 2024-03-01 | Buy |
| Tocris | 2520 | PD166793 ≥99%(HPLC) | 199850-67-4 | 10 | $151 | 2021-12-16 | Buy |
PD 166793 Chemical Properties,Uses,Production
Uses
PD 166793 is a matrix metalloproteinase inhibitor in the treatment of inflammatory pathological occurrences involving blood pressure and the cardiac system.
General Description
A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
Biological Activity
Broad spectrum matrix metalloprotease (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.
Biochem/physiol Actions
Cell permeable: yes
storage
Desiccate at +4°C
PD 166793 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 | sales@alphabiopharm.com | China | 886 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27741 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |