Chloromethyl chloroformate
- CAS No.
- 22128-62-7
- Chemical Name:
- Chloromethyl chloroformate
- Synonyms
- ChloroMethyl carbonochloridate;JMC;CMCF;Tenofovir Impurity 42;Tenofovir Impurity 65;Tenofovir Impurity 241;Tenofovir Impurity 42 CRS;CHLOROMETHYL CHLOROFORMATE;Chloromethylchloroformate,97%;Chloromethyl chloromethanoate
- CBNumber:
- CB3271092
- Molecular Formula:
- C2H2Cl2O2
- Molecular Weight:
- 128.94
- MDL Number:
- MFCD00077688
- MOL File:
- 22128-62-7.mol
- MSDS File:
- SDS
| Melting point | <-20°C |
|---|---|
| Boiling point | 107-108 °C(lit.) |
| Density | 1.449 g/mL at 20 °C |
| refractive index |
n |
| Flash point | 95°C |
| storage temp. | 2-8°C |
| solubility | Chloroform (Soluble), Methanol (Slightly) |
| form | clear liquid |
| color | Colorless to Light yellow to Light orange |
| Water Solubility | Slightly miscible with water. |
| Sensitive | Moisture Sensitive |
| BRN | 506426 |
| Stability | Extremely Moisture Sensitive, Hygroscopic |
| CAS DataBase Reference | 22128-62-7(CAS DataBase Reference) |
| EPA Substance Registry System | Carbonochloridic acid, chloromethyl ester (22128-62-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H331 | |||||||||
| Precautionary statements | P261-P271-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23-34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2745 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-19-21 | |||||||||
| HS Code | 2915.90.5050 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| NFPA 704 |
|
Chloromethyl chloroformate Chemical Properties,Uses,Production
Chemical Properties
Chloromethyl chloroformate is Clear Colourless Oil
Uses
Chloromethyl chloroformate is used as a reagent in the synthesis of carbamates and carbonates.
Uses
Chloromethyl chloroformate is used as an intermediate in pharmaceuticals and in manufacture other chemicals. It acts as a reactant in the synthesis of aminocarbonyloxymethyl esters of diclofenac, flufenamic acid and in monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A.
Synthesis Reference(s)
Journal of the American Chemical Society, 106, p. 1808, 1984 DOI: 10.1021/ja00318a042
General Description
Chloromethyl chloroformate is a colorless liquid with a penetrating, irritating odor. Denser than water. Contact may irritate skin, eyes and mucous membranes. Toxic by ingestion, inhalation and skin absorption. Used to make other chemicals.
Air & Water Reactions
Reacts with moisture in air to generate heat and hydrochloric acid fumes [Merck, 11th ed., 1989]. Reacts with water.
Reactivity Profile
CHLOROMETHYLCHLOROFORMATE is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Vapors may accumulate in confined areas (basement, tanks, hopper/tank cars etc.). Substance will react with water (some violently), releasing corrosive and/or toxic gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.