NIALAMIDE
- CAS No.
- 51-12-7
- Chemical Name:
- NIALAMIDE
- Synonyms
- BEIH;Mygal;Espril;Niamid;Niazin;Nyazin;Nyezin;P 1133;Surgex;NF-XIII
- CBNumber:
- CB3687497
- Molecular Formula:
- C16H18N4O2
- Molecular Weight:
- 298.34
- MDL Number:
- MFCD00010106
- MOL File:
- 51-12-7.mol
- MSDS File:
- SDS
| Melting point | 152-154 °C(lit.) |
|---|---|
| Boiling point | 439.76°C (rough estimate) |
| Density | 1.1183 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | −20°C |
| solubility | ethanol: clear to hazy |
| pka | 11.13±0.23(Predicted) |
| Merck | 13,6515 |
| BRN | 492941 |
| FDA UNII | T2Q0RYM725 |
| ATC code | N06AF02 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335-H351 |
| Precautionary statements | P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38-40 |
| Safety Statements | 22-26-36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | NS1225000 |
| F | 10 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 in mice, rats (mg/kg): 1000, 1700 orally; 742, 760 i.p. (Delahunt) |
NIALAMIDE price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 252999 | Nialamide 95% | 51-12-7 | 1g | $118 | 2023-06-20 | Buy |
| Usbiological | 460720 | Nialamide | 51-12-7 | 500mg | $460 | 2021-12-16 | Buy |
| TRC | N407730 | Nialamide | 51-12-7 | 5g | $1260 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 47844 | Nialamide | 51-12-7 | 5G | $2200 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001027 | NIALAMIDE 95.00% | 51-12-7 | 100MG | $902 | 2021-12-16 | Buy |
NIALAMIDE Chemical Properties,Uses,Production
Chemical Properties
White, crystalline powder. Low solubility in water; good solubility in slightly acid solution. It is stable in crystalline form, suspension, and solution.
Originator
Niamid,Pfizer,US,1959
Uses
MAO inhibitor
Uses
Nialamide is a nonselective monoamine oxidase (MAO) inhibitor that is used as an antidepressant.
Definition
ChEBI: 3-[[oxo(pyridin-4-yl)methyl]hydrazo]-N-(phenylmethyl)propanamide is an organooxygen compound and an organonitrogen compound. It is functionally related to a beta-amino acid.
Manufacturing Process
Methyl acrylate, 28.0 g (0.4 mol) was added dropwise during one hour to a
solution containing 54.8 g (0.4 mol) of isonicotinic acid hydrazide (isoniazid)
and 10 ml of glacial acetic acid in 400 ml of tertiary butyl alcohol. The
resulting solution then was heated for 18 hours on a steam bath.
Concentration of the reaction mixture to 100 ml yielded 13.0 g of unreacted
isonicotinic acid hydrazide. The filtrate was concentrated to a thick syrup
which was triturated with anhydrous ether and recrystallized from isopropyl
alcohol; MP 87°C to 88.5°C. Elemental analysis of the product gave 1-
isonicotinyl-2-(β-carbomethoxyethyl)hydrazine.
A slurry of 7.5 g (0.034 mol) of 1-isonicotinyl-2-(carbomethoxyethyl)-
hydrazine and 5 ml of benzylamine is heated with stirring at 130°C for three
hours. The cooled mass is then recrystallized from ethyl acetate to yield white
needles melting at 151.1°C to 152.1°C.
brand name
Nialamid;Niamidal;Niamide;Niaquital;Niaquitil;Novazid;Nuredal;Psyco-retard;Surgexl.
Therapeutic Function
Antidepressant
World Health Organization (WHO)
Nialamide, a monoamine oxidase inhibitor (MAOI), was introduced in 1959 for the treatment of depressive illness. Subsequently concern regarding potentially serious interactions between MAOIs and foods containing tyramine inspired much restrictive regulatory action. However, MAOIs still retain a place in the treatment of serious depressive illness although there is no international consensus on which compounds should be preferred. Thus nialamide remains available in several countries.
General Description
Nialamide is an antidepressant drug and its effect on β-adrenergic receptor-adenylate cyclase system of rat pineal gland has been studied. Antidepressant action of the combination of nialamide and 5-hydroxytryptophan has been evaluated.
Hazard
Toxic in overdose.
Safety Profile
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.Mutation data reported. Experimental reproductiveeffects. An antidepressant. When heated to decompositionit emits toxic fumes of NOx.
NIALAMIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12990 | 57 | |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14443 | 57 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Derthon Optoelectronic Materials Sci. Tech. Co., Ltd. | 0755-26718755 13266723223 | sales@derthon.com | China | 952 | 56 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | cb6@aikonchem.com | China | 16687 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 10007 | 58 |