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Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate structure

CAS No.: 144689-93-0

Chemical Name:: Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate

Synonyms: 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-iMidazole-5-carboxylate;ETHYL-4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-IMIDAZOLE-5-CARBOXYLATE;Olmesartan intermediate;4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid;5-(1-HYDROXYL-1-METHYLETHYL)-2-PROPYL-IMIDAZOL-4-YLCARBOXYLIC ACID ETHYL ESTER;1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl ester;OMSTint-D;)-2-propyL;Olmesartan Impurity 2

CBNumber:: CB4151009

Molecular Formula:: C12H20N2O3

Molecular Weight:: 240.3

MDL Number:: MFCD07787565

MOL File:: 144689-93-0.mol

MSDS File:: SDS

Last updated:2024-05-14 16:41:43

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Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Properties

Melting point	98-100°C
Boiling point	456.2±35.0 °C(Predicted)
Density	1.131±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform, Ethyl Acetate, Methanol
form	Solid
pka	11.61±0.10(Predicted)
color	Pale Yellow
InChI	InChI=1S/C12H20N2O3/c1-5-7-8-13-9(11(15)17-6-2)10(14-8)12(3,4)16/h16H,5-7H2,1-4H3,(H,13,14)
InChIKey	KZBJJAFGNMRRHN-UHFFFAOYSA-N
SMILES	C1(CCC)NC(C(OCC)=O)=C(C(O)(C)C)N=1
CAS DataBase Reference	144689-93-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319
Precautionary statements	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
HS Code	2933.29.9000

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	E0976	Ethyl 4-(2-Hydroxy-2-propyl)-2-propyl-1H-imidazole-5-carboxylate >96.0%(GC)(T)	144689-93-0	5g	$112	2021-12-16	Buy
TCI Chemical	E0976	Ethyl 4-(2-Hydroxy-2-propyl)-2-propyl-1H-imidazole-5-carboxylate >96.0%(GC)(T)	144689-93-0	25g	$252	2023-06-20	Buy
TRC	H946900	4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylicAcidEthylEster	144689-93-0	1g	$110	2021-12-16	Buy
American Custom Chemicals Corporation	API0025183	OLMESARTAN IMPURITY 95.00%	144689-93-0	10G	$1824.9	2021-12-16	Buy
AK Scientific	J11288	OlmesartanImpurity2	144689-93-0	25mg	$59	2021-12-16	Buy

Product number	Packaging	Price	Buy
E0976	5g	$112	Buy
E0976	25g	$252	Buy
H946900	1g	$110	Buy
API0025183	10G	$1824.9	Buy
J11288	25mg	$59	Buy

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

An Olmesartan (O550000) intermediate.

Application

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is a synthetic drug with pharmacological properties that are similar to those of the natural product medoxomil. It has been shown to be a potent blocker of the GABA receptor and is used for the treatment of epilepsy.It has been shown to be an inhibitor of rat liver microsomes and also has a high affinity for the enzyme cilexetil, which is responsible for the conversion of cilexetil into its active form.

Synthesis

To a solution of MeMgCl(55.86 g, 0.74 mol) in tetrahydrofuran was added a solution of diethyl 2-propyl imidazole- 4,5-dicarboxylate (50 g,0.19 mol) in tetrahydrofuran (200 ml) at -10 to 0°C under N2 atmosphere. The mixture was stirred at -5 to 0°C for 10 minutes. The reaction mass was quenched into 400 ml 25 % ammonium chloride solution, followed by extraction with ethyl acetate (300 ml). The organic phase was separated, washed with brine, dried over Na2SO4, and concentrated in vacuo to give Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate, which was crystallized using diisopropyl ether. Yield: 85-90 %.

Definition

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is a crucial intermediate for the synthesis of olmesartan medoxomil, which can be produced via the reaction of diethyl 2-propyl-imidazole-4,5-dicarboxylate, the raw material, with methylmagnesium bromide, followed by the acidification with saturated ammonium chloride solution.

Hazard

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate is sensitive to the skin and may cause allergic skin reactions. It is irritating to the skin and eyes and may also cause respiratory irritation. It is poisonous to aquatic organisms.

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate synthesis

Synthesis of Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate from Methyl bromide and Diethyl 2-propylImidazoledicarbonate

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

Olmesartan Medoxomil Trityl olmesartan Trityl Olmesartan Medoxomil 1H-IMidazole-5-carboxylic acid, 4-(1-hydroxy-1-Methylethyl)-2-propyl-1-[[2'-[1-(triphenylMethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-, ethyl ester

Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Suppliers

Global( 506)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Zhuhai Hairuide Bioscience and Technology Co., Ltd	+8618928027945	sales3@zhhairuide.com	China	97	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD	+86-576-88902229;+86-0576-88902229 +8613968687450	yuxin@yuxchem.com	China	122	58
Jinan Dexinjia Bio&Tech Co., Ltd	+86-0531-82375893 +86-15553111391	sales@jndxj.com	China	1199	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
Hangzhou ICH Biofarm Co., Ltd	+undefined8613073685410	sales@ichemie.com	China	985	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18232	58
airuikechemical co., ltd.	+undefined86-15315557071	sales05@airuikechemical.com	China	994	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	952	58

Supplier	Advantage
Zhuhai Hairuide Bioscience and Technology Co., Ltd	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD	58
Jinan Dexinjia Bio&Tech Co., Ltd	58
Sinoway Industrial co., ltd.	58
Hangzhou ICH Biofarm Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
airuikechemical co., ltd.	58
hebei hongtan Biotechnology Co., Ltd	58

View Lastest Price from Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-05-16	4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester 144689-93-0	US $5.00 / kg	1kg	≥98%	200mt/year	Jinan Finer Chemical Co., Ltd
2024-05-16	4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester 144689-93-0	US $30.00 / kg	1kg	98%	2000kg	hebei hongtan Biotechnology Co., Ltd
2024-05-08	Olmesartan Intermediate 144689-93-0	US $0.00 / kg	1kg	99%	20tons	Sinoway Industrial co., ltd.

4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester
144689-93-0
US $5.00 / kg
≥98%
Jinan Finer Chemical Co., Ltd

4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester
144689-93-0
US $30.00 / kg
98%
hebei hongtan Biotechnology Co., Ltd

Olmesartan Intermediate
144689-93-0
US $0.00 / kg
99%
Sinoway Industrial co., ltd.

144689-93-0(Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate)Related Search:

Olmesartan Calcitonin salmon Olmesartan 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester OlMesartan Methyl Ester

5-[4’-Hydroxymethyl-(1,1’-biphenyl)-2-yl]-1-triphenylmethyltetrazole 4-Cloromethyl-5-methyl-1,3-dioxol-2-one 2,2'-(2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-diyl)bis(propan-2-ol) 3,6-Dihydro-6,6-diMethyl-2-propyl-3-[[2'-[2-(triphenylMethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-4H-furo[3,4-d]iMidazol-4-one OlMesartan MedoxoMil iMpurity V

N-Trityl Olmesartan Ethyl Ester Diethyl 2-propylImidazoledicarbonate OlMesartan MedoxoMil Butyl IMpurity Olmesartan Impurity 12 5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole

4,5-Dimethyl-1,3-dioxol-2-one 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid Olmesartan Impurity 10

1of4

1H-Imidazole-4-carboxylicacid,5-(1-hydroxy-1-met 1H-Imidazole-5-carboxylicacid,4-(1-hydroxy-1-met 1H-Imidazole-4-carboxylic acid,5-(1-hydroxy-1-methylethyl)-2- propyl-,ethyl ester 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 98+% 5-(1-hydroxy-1-methylethyl)-2-propyl-,ethyl ester 4-(1-Hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid ethyl ester 4-(1-Hydroxy-1-methylethyl)-2-propyl- 5-(1-hydroxy-1-Methylethyl)-2-propyl-1H-IMidazole- 4-carboxylic acid ethyl ester 1H-Imidazole-4-carboxylic acid, 5-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl ester (9CI) 5-(1-Hydroxy-1-Methyl-ethyl)-2-propyl-3H-iMidazole-4-carboxylic acid ethyl ester Ethyl 4-(2-Hydroxy-2-propyl)-2-propyl-1H-iMidazole-5-carboxylate OlMesartan IMidazole Ethyl Ester IMpurity 1h-iMdazole-4-carboxylic acid, 5-(1-hydroxy-1-Methylethyl)-2-propyl-,ethyl ester 1H-IMIDAZOLE-4-CARBOXYLIC ACID-5-(1-HYDROXY-1-METHYETHYL)-2-PROPYL-ETHYL ESTER OlMesartan IMpurity (Ethyl 4-(1-Hydroxy-1-Methylethyl)-2- Propyl-IMidazole-5-Carboxylate) 4-(2-Hydroxypropan-2-yl)-2-propyl-1H-iMidazole-5-carboxylic acid ethyl ester (EPIC) Ethyl 4-(1-hydroxy-1-Methylethyl)-2-propyliM... Ethyl 4-(2-Hydroxy-2-propyl)-2-propyl-1H-imidazole-5-carboxylate 4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester (OM-7) 4-(1-Hydroxy-isopropyl)-2-propyl-1H-imidazol-5-carboxylic acid ethyl ester Olmesartan Medoxomil Impurity 33 Olmesartan Medoxomil-18 OMSTint-D ethyl 5-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-4-carboxylate Olmesartan Impurity 2 Olmesartan Impurity 50 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Ethyl4-(2-Hydroxy-2-propyl)-2-propyl-1H-imidazole-5-carboxylate> 4-(1-hydroxy-1-methyL 4-(1-Hydroxy-1-methylethyl)-2-Propyl-1H-Imiidazole 5-Carboxylic acid ethyl ester )-2-propyL 4-(2-hydroxy-2-propyl) -2-propyl-1H-imidazole-5-formate, ethyl ester 4-(2-Hydroxy-2-propyl)-2-propyl-1H-imidazole-5-carboxylic Acid Ethyl Ester Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate USP/EP/BP 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester for olmesartan 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYL IC ACID ETHYL ESTEROLE Imidazole-5-carboxylic ethyl ester [5-(1-Hydroxyl-1-methylethyl)-2-propyl-imidazol-4-yl]carboxy... Azilsartan medoxomil impurity230 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-1H-IMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER ETHYL-4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYL-IMIDAZOLE-5-CARBOXYLATE Olmesartan intermediate 5-(1-HYDROXYL-1-METHYLETHYL)-2-PROPYL-IMIDAZOL-4-YLCARBOXYLIC ACID ETHYL ESTER 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-, ethyl ester ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-iMidazole-5-carboxylate 4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate (Olmesartan Impurity) 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxyhio acid ethyl ester (1-Hydroxyl-1-methylethyl)-2-propyl-imidazol-4- yl]carboxylic acid ethyl ester Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carbo Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazol-5-carboxylate Ethyl 5-(1-Hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4-carboxylate Olmesartan ester impurity 27 Ethy-4-(1-Hydroxy-1-Mmethylethyl)-2-propylImidazole-5-Carboxylate. Ethyl5-(1-Hydroxy-1-methyl-ethyl)-2-propyl-3H-imidazole-4- carboxylate (Imidazole Ester) Olmesartan Imidazole Ethyl Ester Impurity Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5- carboxylate OLM intermediate (4-(1-Hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylic acid ethyl ester) 4-(1-hydroxy-1-methylethyl)-2-propyl-1H-Imidazole