LY2409881 trihydrochloride
- CAS No.
- 946518-60-1
- Chemical Name:
- LY2409881 trihydrochloride
- Synonyms
- LY2409881;CS-1620;LY2409881 3HCl;LY-2409881 HC'l;LY2409881 triHCl;LY-2409881 ;LY 2409881;LY2409881 trihydrochloride;LY2409881 trihydrochloride USP/EP/BP;2-[5-chloro-2-[3-(4-methylpiperazin-1-yl)propylamino]pyrimidin-4-yl]-N-cyclopropyl-1-benzothiophene-4-carboxamide;LY2409881 trihydrochloride,Inhibitor,IκB kinase,Apoptosis,IKK,inhibit,I kappa B kinase,LY-2409881 trihydrochloride
- CBNumber:
- CB42743099
- Molecular Formula:
- C24H30Cl2N6OS
- Molecular Weight:
- 521.51
- MDL Number:
- MFCD28900676
- MOL File:
- 946518-60-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
LY2409881 trihydrochloride price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18774 | LY2409881 ≥98% | 946518-60-1 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18774 | LY2409881 ≥98% | 946518-60-1 | 5mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 18774 | LY2409881 ≥98% | 946518-60-1 | 10mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 18774 | LY2409881 ≥98% | 946518-60-1 | 25mg | $305 | 2024-03-01 | Buy |
| TRC | C370110 | 2-[5-Chloro-2-[[3-(4-methylpiperazin-1-yl)propyl]amino]pyrimidin-4-yl]benzo[b]thiophene-4-carboxamideN-cyclopropylTrihydrochloride | 946518-60-1 | 2.5mg | $120 | 2021-12-16 | Buy |
LY2409881 trihydrochloride Chemical Properties,Uses,Production
Uses
2-[5-Chloro-2-[[3-(4-methylpiperazin-1-yl)propyl]amino]pyrimidin-4-yl]benzo[b]thiophene-4-carboxamide N-cyclopropyl Trihydrochloride is an inhibitor of IkB-kinase (IKK2). Small molecules that inhibits IkB-kinase and NF-κB pathways are potential anti-inflammatory drug candidate.
Biological Activity
ly2409881 is a potent and selective inhibitor of ikk2 with ic50 value of 30 nm [1].iκb kinase β (ikk2) is an enzyme that serves as a subunit of iκb kinase, which is involved in the cytokine-activated immune responses. ikk2 activates nuclear factor kappa-b kinase (nf-κb).ly2409881 is a selective ikk2 inhibitor and exhibited >10-fold selectivity over other common kinases and ikk1. in the ovarian cancer cell line skov3, ly2409881 showed moderate cytotoxicity. while coadministration of ly2409881 and tnfɑ significantly induced cells death, which suggested ly2409881 inhibited nf-κb mediated antiapoptotic signals in a tnfɑ-dependent way. in the dlbcl cell line ly10, ly2409881 (10 μm) inhibited tnfɑ-dependent phosphorylation of iκb. in the dlbcl cell line sudhl2, ly2409881 (10 μm) inhibited the nuclear signals of p50 and nf-κb. also, ly2409881 induced apoptosis in a concentration-dependent way [1].in scid-beige mice bearing ly10 cell-derived tumors, ly2409881 (50, 100 and 200 mg/kg) significantly inhibited tumor growth [1].
References
[1]. deng c, lipstein m, rodriguez r, et al. the novel ikk2 inhibitor ly2409881 potently synergizes with histone deacetylase inhibitors in preclinical models of lymphoma through the downregulation of nf-κb. clin cancer res, 2015, 21(1): 134-145.
LY2409881 trihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28659 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
View Lastest Price from LY2409881 trihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-24 | LY2409881 trihydrochloride
946518-60-1
|
US $1.00 / g | 1g | 99% | 20kg | Career Henan Chemical Co |
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- LY2409881 trihydrochloride
946518-60-1
- US $1.00 / g
- 99%
- Career Henan Chemical Co