LY-2562175
- CAS No.
- 1103500-20-4
- Chemical Name:
- LY-2562175
- Synonyms
- CS-2847;LY-2562175;LY 2562175,NR1H4,Inhibitor,LY-2562175,Autophagy,LY2562175,inhibit,FXR;6-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid;1H-Indole-3-carboxylic acid, 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]-1-piperidinyl]-1-methyl-
- CBNumber:
- CB83303953
- Molecular Formula:
- C28H27Cl2N3O4
- Molecular Weight:
- 540.44
- MDL Number:
- MFCD30738721
- MOL File:
- 1103500-20-4.mol
- MSDS File:
- SDS
| Boiling point | 740.1±60.0 °C(Predicted) |
|---|---|
| Density | 1.48±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml |
| form | A crystalline solid |
| pka | 3.43±0.10(Predicted) |
| FDA UNII | VVA2ZDV3LX |
LY-2562175 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28912 | LY2562175 | 1103500-20-4 | 10mg | $1116 | 2024-03-01 | Buy |
| Cayman Chemical | 28912 | LY2562175 | 1103500-20-4 | 25mg | $1918 | 2024-03-01 | Buy |
| Cayman Chemical | 28912 | LY2562175 | 1103500-20-4 | 1mg | $141 | 2024-03-01 | Buy |
| Cayman Chemical | 28912 | LY2562175 | 1103500-20-4 | 5mg | $594 | 2024-03-01 | Buy |
| TRC | L490015 | LY2562175 | 1103500-20-4 | 10mg | $1135 | 2021-12-16 | Buy |
LY-2562175 Chemical Properties,Uses,Production
Description
LY2562175 is a farnesoid X receptor (FXR) agonist (EC50 = 193 nM in a reporter assay). It is selective for FXR over the glucocorticoid, androgen, mineralocorticoid, and progesterone receptors in HEK293 cells overexpressing the human receptors (EC50s = >10 μM for all in a radioligand binding assay). LY2562175 increases the interaction between FXR and steroid receptor coactivator 1 (SRC-1) with an EC50 value of 121 nM in a cell-free assay. It reduces plasma triglyceride and total cholesterol levels in LDL receptor-null mice (ED50s = 3.4 and 2 mg/kg, respectively). LY2562175 also decreases plasma LDL and increases HDL levels in Zucker diabetic fatty (ZDF) rats when administered at doses of 3, 10, and 30 mg/kg for nine days.
Uses
LY2562175, is a potent and selective FXR agonist with an EC50 of 193 nM.
LY-2562175 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| CR Corporation Lomited | fred.wen@crcorporation.cn | CHINA | 12069 | 58 | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 17982 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 |