ChemicalBook >제품 카탈로그 >LY-2562175

LY-2562175

LY-2562175 구조식 이미지

카스 번호:: 1103500-20-4

상품명:: LY-2562175

동의어(영문):: CS-2847;LY-2562175;LY 2562175,NR1H4,Inhibitor,LY-2562175,Autophagy,LY2562175,inhibit,FXR;6-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid;1H-Indole-3-carboxylic acid, 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]-1-piperidinyl]-1-methyl-

CBNumber:: CB83303953

분자식:: C28H27Cl2N3O4

포뮬러 무게:: 540.44

MOL 파일:: 1103500-20-4.mol

속성

안전

용도

공급 업체 37

LY-2562175 속성

끓는 점: 740.1±60.0 °C(Predicted)

밀도: 1.48±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml

물리적 상태: 결정성 고체

산도 계수 (pKa): 3.43±0.10(Predicted)

안전

LY-2562175 C화학적 특성, 용도, 생산

개요

LY2562175 is a farnesoid X receptor (FXR) agonist (EC₅₀ = 193 nM in a reporter assay). It is selective for FXR over the glucocorticoid, androgen, mineralocorticoid, and progesterone receptors in HEK293 cells overexpressing the human receptors (EC₅₀s = >10 μM for all in a radioligand binding assay). LY2562175 increases the interaction between FXR and steroid receptor coactivator 1 (SRC-1) with an EC₅₀ value of 121 nM in a cell-free assay. It reduces plasma triglyceride and total cholesterol levels in LDL receptor-null mice (ED₅₀s = 3.4 and 2 mg/kg, respectively). LY2562175 also decreases plasma LDL and increases HDL levels in Zucker diabetic fatty (ZDF) rats when administered at doses of 3, 10, and 30 mg/kg for nine days.

용도

LY2562175, is a potent and selective FXR agonist with an EC50 of 193 nM.

LY-2562175 준비 용품 및 원자재

원자재

준비 용품

LY-2562175 공급 업체

글로벌( 37)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
CR Corporation Lomited		fred.wen@crcorporation.cn	CHINA	12069	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	17994	56
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4153	55

LY-2562175 관련 검색:

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