LY-2562175
|
- $141 - $2600
- Product name: LY-2562175
- CAS: 1103500-20-4
- MF: C28H27Cl2N3O4
- MW: 540.44
- EINECS:-0
- MDL Number:MFCD30738721
- Synonyms:LY-2562175;CS-2847;1H-Indole-3-carboxylic acid, 6-[4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-4-isoxazolyl]methoxy]-1-piperidinyl]-1-methyl-;LY 2562175,NR1H4,Inhibitor,LY-2562175,Autophagy,LY2562175,inhibit,FXR;6-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid
12 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- DC Chemicals
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number3150DC
- Product description6-[4-[[5-Cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]piperidin-1-yl]-1-methylindole-3-carboxylicacid
- Packaging10mg
- Price$1342
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number28912
- Product descriptionLY2562175
- Packaging1mg
- Price$141
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28912
- Product descriptionLY2562175
- Packaging5mg
- Price$594
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28912
- Product descriptionLY2562175
- Packaging10mg
- Price$1116
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28912
- Product descriptionLY2562175
- Packaging25mg
- Price$1918
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0033341
- Product descriptionLY2562175 99.87%
- Packaging5mg
- Price$380
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0033341
- Product descriptionLY2562175 99.87%
- Packaging10mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0033341
- Product descriptionLY2562175 99.87%
- Packaging50mg
- Price$1750
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC11547
- Product descriptionLY-2562175 >98%
- Packaging100mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC11547
- Product descriptionLY-2562175 >98%
- Packaging250mg
- Price$1300
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC11547
- Product descriptionLY-2562175 >98%
- Packaging1g
- Price$2600
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberL490015
- Product descriptionLY2562175
- Packaging10mg
- Price$1135
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3150DC | 6-[4-[[5-Cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]piperidin-1-yl]-1-methylindole-3-carboxylicacid | 10mg | $1342 | 2021-12-16 | Buy |
| Cayman Chemical | 28912 | LY2562175 | 1mg | $141 | 2024-03-01 | Buy |
| Cayman Chemical | 28912 | LY2562175 | 5mg | $594 | 2024-03-01 | Buy |
| Cayman Chemical | 28912 | LY2562175 | 10mg | $1116 | 2024-03-01 | Buy |
| Cayman Chemical | 28912 | LY2562175 | 25mg | $1918 | 2024-03-01 | Buy |
| ChemScene | CS-0033341 | LY2562175 99.87% | 5mg | $380 | 2021-12-16 | Buy |
| ChemScene | CS-0033341 | LY2562175 99.87% | 10mg | $600 | 2021-12-16 | Buy |
| ChemScene | CS-0033341 | LY2562175 99.87% | 50mg | $1750 | 2021-12-16 | Buy |
| DC Chemicals | DC11547 | LY-2562175 >98% | 100mg | $700 | 2021-12-16 | Buy |
| DC Chemicals | DC11547 | LY-2562175 >98% | 250mg | $1300 | 2021-12-16 | Buy |
| DC Chemicals | DC11547 | LY-2562175 >98% | 1g | $2600 | 2021-12-16 | Buy |
| TRC | L490015 | LY2562175 | 10mg | $1135 | 2021-12-16 | Buy |
Properties
Boiling point :740.1±60.0 °C(Predicted)
Density :1.48±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form :A crystalline solid
pka :3.43±0.10(Predicted)
Density :1.48±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 20 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
form :A crystalline solid
pka :3.43±0.10(Predicted)
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
LY2562175 is a farnesoid X receptor (FXR) agonist (EC50 = 193 nM in a reporter assay). It is selective for FXR over the glucocorticoid, androgen, mineralocorticoid, and progesterone receptors in HEK293 cells overexpressing the human receptors (EC50s = >10 μM for all in a radioligand binding assay). LY2562175 increases the interaction between FXR and steroid receptor coactivator 1 (SRC-1) with an EC50 value of 121 nM in a cell-free assay. It reduces plasma triglyceride and total cholesterol levels in LDL receptor-null mice (ED50s = 3.4 and 2 mg/kg, respectively). LY2562175 also decreases plasma LDL and increases HDL levels in Zucker diabetic fatty (ZDF) rats when administered at doses of 3, 10, and 30 mg/kg for nine days.Related product price
- LY 294002 HYDROCHLORIDE
$20-3350 - LY-364947
$45-18700 - LY2409881 trihydrochloride
$32-1092