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ChemicalBook >> CAS DataBase List >> LY3214996

LY3214996

LY3214996 price.
  • $57 - $2100
  • Product name: LY3214996
  • CAS: 1951483-29-6
  • MF: C22H27N7O2S
  • MW: 453.56
  • EINECS:-0
  • MDL Number:MFCD31544324
  • Synonyms:LY3214996;6,6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5,6-dihydro-4H-thieno[2,3-c]pyrrol-4-one;CS-2495;4H-Thieno[2,3-c]pyrrol-4-one, 5,6-dihydro-6,6-dimethyl-2-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-5-[2-(4-morpholinyl)ethyl]-;Temuterkib;Temuterkib (LY3214996);LY-3214996,LY 3214996,inhibit,Extracellular signal regulated kinases,Temuterkib,Inhibitor,ERK;LY-3214996 (LY3214996)
Price12 Properties Safety Information Description
12 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number5975EG
  • Product descriptionCID121408882
  • Packaging5mg
  • Price$357
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number27936
  • Product descriptionLY3214996
  • Packaging1mg
  • Price$57
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27936
  • Product descriptionLY3214996
  • Packaging5mg
  • Price$233
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27936
  • Product descriptionLY3214996
  • Packaging10mg
  • Price$437
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number27936
  • Product descriptionLY3214996
  • Packaging25mg
  • Price$1026
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6974
  • Product descriptionLY3214996 99.54%
  • Packaging1mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6974
  • Product descriptionLY3214996 99.54%
  • Packaging5mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6974
  • Product descriptionLY3214996 99.54%
  • Packaging10mg
  • Price$380
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6974
  • Product descriptionLY3214996 99.54%
  • Packaging50mg
  • Price$1300
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-6974
  • Product descriptionLY3214996 99.54%
  • Packaging100mg
  • Price$2100
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10640
  • Product descriptionLY3214996 >98%
  • Packaging100mg
  • Price$650
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10640
  • Product descriptionLY3214996 >98%
  • Packaging250mg
  • Price$1300
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5975EG CID121408882 5mg $357 2021-12-16 Buy
Cayman Chemical 27936 LY3214996 1mg $57 2024-03-01 Buy
Cayman Chemical 27936 LY3214996 5mg $233 2024-03-01 Buy
Cayman Chemical 27936 LY3214996 10mg $437 2024-03-01 Buy
Cayman Chemical 27936 LY3214996 25mg $1026 2024-03-01 Buy
ChemScene CS-6974 LY3214996 99.54% 1mg $80 2021-12-16 Buy
ChemScene CS-6974 LY3214996 99.54% 5mg $240 2021-12-16 Buy
ChemScene CS-6974 LY3214996 99.54% 10mg $380 2021-12-16 Buy
ChemScene CS-6974 LY3214996 99.54% 50mg $1300 2021-12-16 Buy
ChemScene CS-6974 LY3214996 99.54% 100mg $2100 2021-12-16 Buy
DC Chemicals DC10640 LY3214996 >98% 100mg $650 2021-12-16 Buy
DC Chemicals DC10640 LY3214996 >98% 250mg $1300 2021-12-16 Buy

Properties

Boiling point :711.5±70.0 °C(Predicted)
Density :1.43±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:23.5(Max Conc. mg/mL);51.81(Max Conc. mM)
Ethanol:16.0(Max Conc. mg/mL);35.28(Max Conc. mM) form :A crystalline solid
pka :6.58±0.10(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

LY3214996 is an inhibitor of ERK1 and ERK2 (IC50 = 5 nM for both). It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models.

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