LY 2784544
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- $62 - $9556.47
- Product name: LY 2784544
- CAS: 1229236-86-5
- MF: C23H25ClFN7O
- MW: 469.94
- EINECS:-0
- MDL Number:MFCD20482143
- Synonyms:LY2784544(gandotinib);3-(4-Chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[;3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-6-amine;LY 2784544;3-[(4-Chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(4-morpholinylmethyl)imidazo[1,2-b]pyridazin-6-amine;3-(4-chloro-2-fluorobenzyl)-2-Methyl-N-(3-Methyl-1H-pyrazol-5-yl)-8-(MorpholinoMethyl)iMidazo[1,2-b]pyridazin-6-aMine;LY2784544/LY-2784544;IMidazo[1,2-b]pyridazin-6-aMine, 3-[(4-chloro-2-fluorophenyl)Methyl]-2-Methyl-N-(5-Methyl-1H-pyrazol-3-yl)-8-(4-MorpholinylMethyl)-
29 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
- Usbiological
Package
- 5mg
- 10mM(in 1mL DMSO)
- 1MG
- 10MG
- 25mg
- 50mg
- 100mg
- 1G
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1196-M050
- Product descriptionLY2784544 ≥95%
- Packaging50mg
- Price$961
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN1196
- Product descriptionLY2784544
- Packaging100mg
- Price$1470
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000940
- Product descriptionLY-2784544 95.00%
- Packaging1MG
- Price$216.3
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000940
- Product descriptionLY-2784544 95.00%
- Packaging10MG
- Price$1006.58
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000940
- Product descriptionLY-2784544 95.00%
- Packaging50MG
- Price$1855.51
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000940
- Product descriptionLY-2784544 95.00%
- Packaging1G
- Price$9556.47
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4147
- Product descriptionLY2784544
- Packaging10mM(in 1mL DMSO)
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2554
- Product descriptionLY2784544-Gandotinib 99%
- Packaging5mg
- Price$104.5
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFL103868
- Product descriptionLY 2784544
- Packaging10mg
- Price$175
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFL103868
- Product descriptionLY 2784544
- Packaging50mg
- Price$612.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16705
- Product descriptionLY2784544 ≥98%
- Packaging1mg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16705
- Product descriptionLY2784544 ≥98%
- Packaging5mg
- Price$135
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16705
- Product descriptionLY2784544 ≥98%
- Packaging10mg
- Price$239
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16705
- Product descriptionLY2784544 ≥98%
- Packaging25mg
- Price$522
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0426
- Product descriptionGandotinib 99.96%
- Packaging5mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0426
- Product descriptionGandotinib 99.96%
- Packaging10mg
- Price$228
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | SYN-1196-M050 | LY2784544 ≥95% | 50mg | $961 | 2021-12-16 | Buy |
| AK Scientific | SYN1196 | LY2784544 | 100mg | $1470 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000940 | LY-2784544 95.00% | 1MG | $216.3 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000940 | LY-2784544 95.00% | 10MG | $1006.58 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000940 | LY-2784544 95.00% | 50MG | $1855.51 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000940 | LY-2784544 95.00% | 1G | $9556.47 | 2021-12-16 | Buy |
| ApexBio Technology | A4147 | LY2784544 | 10mM(in 1mL DMSO) | $120 | 2021-12-16 | Buy |
| Axon Medchem | Axon2554 | LY2784544-Gandotinib 99% | 5mg | $104.5 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL103868 | LY 2784544 | 10mg | $175 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FL103868 | LY 2784544 | 50mg | $612.5 | 2021-12-16 | Buy |
| Cayman Chemical | 16705 | LY2784544 ≥98% | 1mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 16705 | LY2784544 ≥98% | 5mg | $135 | 2024-03-01 | Buy |
| Cayman Chemical | 16705 | LY2784544 ≥98% | 10mg | $239 | 2024-03-01 | Buy |
| Cayman Chemical | 16705 | LY2784544 ≥98% | 25mg | $522 | 2024-03-01 | Buy |
| ChemScene | CS-0426 | Gandotinib 99.96% | 5mg | $132 | 2021-12-16 | Buy |
| ChemScene | CS-0426 | Gandotinib 99.96% | 10mg | $228 | 2021-12-16 | Buy |
Properties
Density :1.45
storage temp. :Store at -20°C
solubility :≥23.5 mg/mL in DMSO; insoluble in H2O; ≥5.65 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :14.12±0.10(Predicted)
storage temp. :Store at -20°C
solubility :≥23.5 mg/mL in DMSO; insoluble in H2O; ≥5.65 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :14.12±0.10(Predicted)
Safety Information
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Description
LY2784544 is a potent, ATP-competitive inhibitor of janus kinase 2 (JAK2) that less effectively inhibits JAK3 (IC50s = 3 and 48 nM, respectively). It also inhibits JAK2 containing the V617F mutation (IC50 = 20 nM), blocking STAT5 phosphorylation and proliferation of Ba/F3 pro-B-cells expressing this constitutively active JAK2 mutant form. When given by oral gavage, LY2784544 significantly reduces the growth of Ba/F3 pro-B-cells in SCID mice without affecting erythroid progenitors, reticulocytes, or platelets. JAK inhibitors, including LY2784544, may be useful in hematological malignancies.More related product prices
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