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4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID structure

CAS No.: 59662-49-6

Chemical Name:: 4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID

Synonyms: 8BCA;AC 55649;AC55649,AC 55649;RARECHEM AL BO 1323;4-(4-Octylphenyl)-benzoic acid;4-OCTYL-4'-BIPHENYLCARBOXYLIC ACID;4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID;4-N-OCTYLBIPHENYL-4'-CARBOXYLIC ACID;4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID;4'-Octyl[1,1'-biphenyl]-4-carboxylic acid

CBNumber:: CB4462046

Molecular Formula:: C21H26O2

Molecular Weight:: 310.43

MDL Number:: MFCD00157040

MOL File:: 59662-49-6.mol

Last updated:2023-05-18 11:31:14

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4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Properties

Melting point	148-152 °C(Solv: dichloromethane (75-09-2))
Boiling point	462.0±34.0 °C(Predicted)
Density	1.037±0.06 g/cm3(Predicted)
storage temp.	Store at +4°C
solubility	DMSO: >7mg/mL
form	solid
pka	4.23±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H413
WGK Germany	3

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S945579	4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID Aldrich	59662-49-6	25mg	$179	2024-03-01	Buy
Tocris	2436	AC55649 ≥99%(HPLC)	59662-49-6	50	$593	2021-12-16	Buy
TRC	A192203	AC55649	59662-49-6	25mg	$370	2021-12-16	Buy
Usbiological	254514	AC 55649	59662-49-6	10mg	$380	2021-12-16	Buy
ApexBio Technology	B7052	AC55649	59662-49-6	10mg	$219	2021-12-16	Buy

Product number	Packaging	Price	Buy
S945579	25mg	$179	Buy
2436	50	$593	Buy
A192203	25mg	$370	Buy
254514	10mg	$380	Buy
B7052	10mg	$219	Buy

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Chemical Properties,Uses,Production

Uses

AC 55649 is a potent and selective RARβ2 receptor agonist (1). RARβ2 receptor agonists are potential drug candidates for developing treatment for type 2 diabetes and hepatic steatosis (2).

Definition

ChEBI: 4-(4-octylphenyl)benzoic acid is a member of biphenyls and a carboxybiphenyl.

Biological Activity

Potent, isoform-selective RAR β 2 receptor agonist (pEC 50 values are 6.9, 5.7 and 5.6 at RAR β 2, RAR β 1 and RAR α respectively) that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7.

Biochem/physiol Actions

AC-55649 is a subtype selective RAR (RARβ2) agonist. AC-55649 is a potent, orally available isoform selective Retinoic Acid Receptor β2. AC-55649 has high selectivity, 99% for RARβ2 and 31% for RARβ1. When compared to the gold standard AM-580 (Cat. No A8843), both isoform receptors were 100%. AC-55649 has a potent EC50 of 6.9 μM compared to an EC50 of 7.7 μM for AM-580.

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID Suppliers

Global( 64)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	4398	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18	sales@capotchem.com	China	18217	66
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4153	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60

Supplier	Advantage
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Amadis Chemical Company Limited	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Capot Chemical Co., Ltd	66
Sigma-Aldrich	80
Shanghai Lollane Biological Technology Co.,Ltd.	55
EMMX Biotechnology LLC	60

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4'-N-OCTYLBIPHENYL-4-CARBOXYLIC ACID 4-N-OCTYLBIPHENYL-4'-CARBOXYLIC ACID 4'-OCTYL-[1,1'-BIPHENYL]-4-CARBOXYLIC ACID 4'-OCTYL-4-BIPHENYLCARBOXYLIC ACID 4-OCTYL-4'-BIPHENYLCARBOXYLIC ACID 8BCA AC 55649 4-(4-Octylphenyl)-benzoic acid 4′-Octyl-4-biphenylcarboxylic acid, 4′-n-octylbiphenyl-4-carboxylic acid RARECHEM AL BO 1323 [1,1'-Biphenyl]-4-carboxylic acid, 4'-octyl- AC55649,AC 55649 4'-Octyl[1,1'-biphenyl]-4-carboxylic acid 59662-49-6 Biphenyl & Diphenyl ether