Sobuzoxane
- CAS No.
- 98631-95-9
- Chemical Name:
- Sobuzoxane
- Synonyms
- e)(ester);Sobuzoxane;Perazoline;methylpropyl)ester;1,2-bis(4-isobutoxycarbonyloxymethyl-3,5-dioxo-piperazin-1-yl)ethane;4,4’-ethylenebis(1-(hydroxymethyl)-2,6-piperazinedione)bis(isobutylcarbonat;1,2-ethanediylbis((2,6-dioxo-4,1-piperazinediyl)methylene)bis(2-carbonicaci;4,4'-Ethylenebis(2,6-dioxopiperazine-1-methanol)bis(2-methylpropoxyformate);MST-16, 4,4μ-(1,2-Ethanediyl)bis(1-isobutoxycarbonyloxmethyl-2,6-piperazinedione);Carbonic acid, C,C'-[1,2-ethanediylbis[(2,6-dioxo-4,1-piperazinediyl)methylene]] C,C'-bis(2-methylpropyl) ester
- CBNumber:
- CB4498395
- Molecular Formula:
- C22H34N4O10
- Molecular Weight:
- 514.53
- MDL Number:
- MFCD00866498
- MOL File:
- 98631-95-9.mol
- MSDS File:
- SDS
| Melting point | 128-130°; mp 132-133° (Cai, 1989) |
|---|---|
| Boiling point | 664.9±55.0 °C(Predicted) |
| Density | 1.272±0.06 g/cm3(Predicted) |
| solubility | DMSO: 19 mg/mL |
| pka | 2.75±0.20(Predicted) |
| form | solid |
| FDA UNII | R1308VH37P |
SAFETY
Risk and Safety Statements
| WGK Germany | 2 |
|---|---|
| RTECS | FG1582500 |
| Toxicity | LD50 in male, female mice, rats (mg/kg): 807, 960, 877, 567 i.p.; 400, 673, 3025, 2821 s.c.; >5 g/kg orally in all species (Tokiwa) |
Sobuzoxane price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | S080860 | Sobuzoxane | 98631-95-9 | 5mg | $155 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008426 | SOBUZOXANE 95.00% | 98631-95-9 | 5MG | $719.1 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0008426 | SOBUZOXANE 95.00% | 98631-95-9 | 25MG | $1107.84 | 2021-12-16 | Buy |
| Crysdot | CD11000920 | Sobuzoxane 97% | 98631-95-9 | 100mg | $840 | 2021-12-16 | Buy |
Sobuzoxane Chemical Properties,Uses,Production
Description
Sobuzoxane, a novel bis(2,6-dioxopiperazine) derivative, was introduced in Japan for the treatment of malignant lymphoma and adult T-cell IeukemiaQmphoma (ATLL), which is resistant to chemotherapy and has a poor prognosis. Sobuzoxane exhibits 8 broad spectrum of antitumor activity. It is a noncleavable complexstabilizing topoisomerase II inhibitor and exerts its function via interfering with the catalytic activity of the enzyme to result in an irreversible inhibition of cell division by blockade of chromosome condensation and segregation. Due to Its unique mode of cytocidai activity, it has no cross resistance with many currently available anticancer agents. Sobuzoxane is reported to significantly inhibit growth of human colon, lung, gastric, and breast cancers and is in clinical trials for these indications.
Originator
Zenyaku Kogyo (Japan)
Uses
Sobuzoxane is an inhibitor of DNA topoisomerase II which induces apoptosis.
Definition
ChEBI: Sobuzoxane is an organic molecular entity.
brand name
Perazolln
Sobuzoxane Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
| Heterochem | 027-88041443 13072715837 | sales@hetero-chem.com | China | 696 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |
| Supplier | Advantage |
|---|---|
| CONIER CHEM AND PHARMA LIMITED | 58 |
| Aladdin Scientific | 58 |
| LGM Pharma | 70 |
| Heterochem | 58 |
| United States Biological | 58 |